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01.01.2012 | Original Article

Color of Meconium and Interleukin-6

verfasst von: Raquel Silva-Bravo, Gabriel Mayoral-Andrade, Edgar Zenteno, Pedro Hernandez, Ruth Martínez-Cruz, Laura Perez-Campos Mayoral, Sergio Aguilar-Ruiz, Alberto Paz-Pacheco, Romeo Zarate-Aspiros, Magdalena López-Bravo, Yuri Roldan-Aragon, Eduardo Pérez-Campos

Erschienen in: Indian Journal of Pediatrics | Ausgabe 1/2012

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Abstract

Objective

To test the hypothesis that the color of meconial fluid is associated with inflammatory biomarkers, by determining C-reactive protein (CRP) and Interleukin-6 (IL-6) in serum from the umbilical cord.

Methods

In this prospective study, the authors selected 30 newborns with meconium-stained amniotic fluid (MSAF): 14 with green/brown 656 R color and 16 with brown/cinnamon 654 R color, and 20 newborns which showed clear amniotic fluid without MSAF (non-MSAF); all newborns were from mothers without risk factors for neonatal sepsis.

Results

IL-6 concentration from umbilical cord blood, [median of 12.9 pg/mL (interquartile range {IQR} 8.7–31.0)] of MSAF-green/brown 656 R increased significantly (p < 0.05) when compared with IL-6 concentration, [median of 9.2 pg/mL (IQR 7.2–12.2)] of newborns with clear amniotic fluid and without meconium. CRP from MSAF-green/brown 656 R was median of 0.5 mg/mL (IQR 0.0–2.7), and median of 1.0 mg/mL (IQR 0.0–5.5) from clear amniotic fluid, without meconium.

Conclusions

Significant association was found between MSAF-green/brown 656 R and increase in IL-6, with normal CRP values.

Kimble RM, Trudenger B, Cass D. Fetal defaecation: is it a normal physiological process? J Paediatr Child Health. 1999;35:116–19.PubMedCrossRef

Scott H, Walker M, Gruslin A. Significance of meconium-stained amniotic fluid in the preterm population. J Perinatol. 2001;21:174–7.PubMedCrossRef

Parida SN, Verma IC, Thomas S, Sachdev HPS. Meconium staining of amniotic fluid and its association with fetal distress and gestational age. Indian J Pediatr. 1980;47:141–3.PubMedCrossRef

David AN, Njokanma OF, Iroha E. Incidence of and factors associated with meconium staining of the amniotic fluid in a Nigerian University Teaching Hospital. J Obstet Gynaecol. 2006;26:518–20.PubMedCrossRef

Hess LW, Anderson RL, Golbus MS. Significance of opaque discolored amniotic fluid at second-trimester amniocentesis. Obstet Gynecol. 1986;67:44–6.PubMed

Isada NB, Koppitch 3rd FC, Johnson MP, Evans MI. Does the color of amniotic fluid still matter? Fetal Diagn Ther. 1990;5:165–7.PubMedCrossRef

Steinborn A, Günes H, Röddiger S, Halberstadt E. Elevated placental cytokine release, a process associated with preterm labor in the absence of intrauterine infection. Obstet Gynecol. 1996;88:534–9.PubMedCrossRef

de Beaufort AJ, Bakker AC, van Tol MJ, Poorthuis BJ, Schrama AJ, Berger HM. Meconium is a source of pro-inflammatory substances and can induce cytokine production in cultured A549 epithelial cells. Pediatr Res. 2003;54:491–5.PubMedCrossRef

Glynn EF. Color Chart. Stowers Institute for Medical Research. Mushegian Lab Bioinformatic Center 2008. [Updated 31 Oct 2008; cited 24 May 2005]. Available from: http://research.stowers-institute.org/efg/R/Color/Chart/ [Assessed 18th February, 2011].

10.

Hsieh TT, Hsieh CC, Hung TH, Chiang CH, Yang FP, Pao CC. Differential expression of interleukin-1 beta and interleukin-6 in human fetal serum and meconium-stained amniotic fluid. J Reprod Immunol. 1998;37:155–61.PubMedCrossRef

11.

Liu Y, Li P, Lu J, et al. Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis. J Immunol. 2008;181:1887–97.PubMed

12.

Tasci Y, Dilbaz B, Uzmez Onal B, Caliskan E, Dilbaz S, Doganci L, et al. The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. Eur J Obstet Gynecol Reprod Biol. 2006;128:34–9.PubMedCrossRef

13.

Cicco NA, Lindemann A, Content J, et al. Inducible production of interleukin-6 by human polymorphonuclear neutrophils: role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Blood. 1990;75:2049–52.PubMed

14.

Suwa T, Hogg JC, Klut ME, Hards J, van Eeden SF. Interleukin-6 changes deformability of neutrophils and induces their sequestration in the lung. Am J Respir Crit Care Med. 2001;163:970–6.PubMed

15.

Suwa T, Hogg JC, English D, Van Eeden SF. Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow. Am J Physiol Heart Circ Physiol. 2000;279:H2954–60.PubMed

16.

Marchini G, Hagenäs L, Kocoska-Maras L, Berggren V, Hansson LO. Insulin-like growth factor binding protein-1 and interleukin-6 are markers of fetal stress during parturition at term gestation. J Pediatr Endocrinol Metab. 2005;18:777–83.PubMedCrossRef

17.

Majello B, Arcone R, Toniatti C, Ciliberto G. Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J. 1990;9:457–65.PubMed

18.

Ganapathi MK, Rzewnicki D, Samols D, Jiang SL, Kushner I. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep 3B cells. J Immunol. 1991;147:1261–5.PubMed

Titel: Color of Meconium and Interleukin-6
verfasst von: Raquel Silva-Bravo
Gabriel Mayoral-Andrade
Edgar Zenteno
Pedro Hernandez
Ruth Martínez-Cruz
Laura Perez-Campos Mayoral
Sergio Aguilar-Ruiz
Alberto Paz-Pacheco
Romeo Zarate-Aspiros
Magdalena López-Bravo
Yuri Roldan-Aragon
Eduardo Pérez-Campos
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: Indian Journal of Pediatrics / Ausgabe 1/2012
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-011-0447-4

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Color of Meconium and Interleukin-6