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10.03.2016 | Head and Neck

Combining standardized uptake value of FDG-PET and apparent diffusion coefficient of DW-MRI improves risk stratification in head and neck squamous cell carcinoma

verfasst von: Lorenzo Preda, Giorgio Conte, Luke Bonello, Caterina Giannitto, Laura L. Travaini, Sara Raimondi, Paul E. Summers, Ansarin Mohssen, Daniela Alterio, Maria Cossu Rocca, Chiara Grana, Francesca Ruju, Massimo Bellomi

Erschienen in: European Radiology | Ausgabe 12/2016

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Abstract

Objectives

To assess the independent prognostic value of standardized uptake value (SUV) and apparent diffusion coefficient (ADC), separately and combined, in order to evaluate if the combination of these two variables allows further prognostic stratification of patients with head and neck squamous cell carcinomas (HNSCC).

Methods

Pretreatment SUV and ADC were calculated in 57 patients with HNSCC. Mean follow-up was 21.3 months. Semiquantitative analysis of primary tumours was performed using SUV_maxT/B, ADC_mean, ADC_min and ADC_max. The prognostic value of SUV_maxT/B, ADC_mean, ADC_min and ADC_max in predicting disease-free survival (DFS) was evaluated with log-rank test and Cox regression models.

Results

Patients with SUV_maxT/B ≥5.75 had an overall worse prognosis (p = 0.003). After adjusting for lymph node status and diameter, SUV_maxT/B and ADC_min were both significant predictors of DFS with hazard ratio (HR) = 10.37 (95 % CI 1.22–87.95) and 3.26 (95 % CI 1.20–8.85) for SUV_maxT/B ≥5.75 and ADC_min ≥0.58 × 10⁻³ mm²/s, respectively. When the analysis was restricted to subjects with SUV_maxT/B ≥5.75, high ADC_min significantly predicted a worse prognosis, with adjusted HR = 3.11 (95 % CI 1.13–8.55).

Conclusions

The combination of SUV_maxT/B and ADC_min improves the prognostic role of the two separate parameters; patients with high SUV_maxT/B and high ADC_min are associated with a poor prognosis.

Key Points

• High SUV _maxT/B is a poor prognostic factor in HNSCC

• High ADC _min is a poor prognostic factor in HNSCC

• In patients with high SUV _maxT/B , high ADC _min identified those with worse prognosis

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Argiris A, Karamouzis MV, Raben D, Ferris RL (2008) Head and neck cancer. Lancet 371:1695–1709CrossRefPubMed

Partovi S, Kohan A, Vercher-Conejero JL et al (2014) Qualitative and quantitative performance of ¹⁸F-FDG-PET/MRI versus ¹⁸F-FDG-PET/CT in patients with head and neck cancer. AJNR Am J Neuroradiol 35:1970–1975CrossRefPubMed

Partovi S, Robbin MR, Steinbach OC et al (2014) Initial experience of MR/PET in a clinical cancer center. J Magn Reson Imaging 39:768–780CrossRefPubMed

Varoquaux A, Rager O, Lovblad KO et al (2013) Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV. Eur J Nucl Med Mol Imaging 40:842–852CrossRefPubMedPubMedCentral

Choi SH, Paeng JC, Sohn CH et al (2011) Correlation of 18F-FDG uptake with apparent diffusion coefficient ratio measured on standard and high b value diffusion MRI in head and neck cancer. J Nucl Med 52:1056–1062CrossRefPubMed

Purohit BS, Ailianou A, Dulguerov N, Becker CD, Ratib O, Becker M (2014) FDG-PET/CT pitfalls in oncological head and neck imaging. Insights Imaging 5:585–602CrossRefPubMedPubMedCentral

Zhang XY, Sun YS, Tang L, Xue WC, Zhang XP (2011) Correlation of diffusion-weighted imaging data with apoptotic and proliferation indexes in CT26 colorectal tumor homografts in balb/c mouse. J Magn Reson Imaging 33:1171–1176CrossRefPubMed

Chen Z, Ma L, Lou X, Zhou Z (2010) Diagnostic value of minimum apparent diffusion coefficient values in prediction of neuroepithelial tumor grading. J Magn Reson Imaging 31:1331–1338CrossRefPubMed

Thoeny HC, De Keyzer F, King AD (2012) Diffusion-weighted MR imaging in the head and neck. Radiology 263:19–32CrossRefPubMed

10.

Driessen JP, Caldas-Magalhaes J, Janssen LM et al (2014) Diffusion-weighted MR imaging in laryngeal and hypopharyngeal carcinoma: association between apparent diffusion coefficient and histologic findings. Radiology 272:456–463CrossRefPubMed

11.

Roh JL, Pae KH, Choi SH et al (2007) 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol 33:790–795CrossRefPubMed

12.

Machtay M, Natwa M, Andrel J et al (2009) Pretreatment FDG-PET standardized uptake value as a prognostic factor for outcome in head and neck cancer. Head Neck 31:195–201CrossRefPubMed

13.

Hatakenaka M, Shioyama Y, Nakamura K et al (2011) Apparent diffusion coefficient calculated with relatively high b-values correlates with local failure of head and neck squamous cell carcinoma treated with radiotherapy. AJNR Am J Neuroradiol 32:1904–1910CrossRefPubMed

14.

Kim S, Loevner L, Quon H et al (2009) Diffusion-weighted magnetic resonance imaging for predicting and detecting early response to chemoradiation therapy of squamous cell carcinoma of the head and neck. Clin Cancer Res 15:986–994CrossRefPubMedPubMedCentral

15.

Lambrecht M, Van Calster B, Vandecaveye V et al (2014) Integrating pretreatment diffusion weighted MRI into a multivariable prognostic model for head and neck squamous cell carcinoma. Radiother Oncol 110:429–434CrossRefPubMed

16.

Nakajo M, Nakajo M, Kajiya Y et al (2012) FDG PET/CT and diffusion-weighted imaging of head and neck squamous cell carcinoma: comparison of prognostic significance between primary tumor standardized uptake value and apparent diffusion coefficient. Clin Nucl Med 37:475–480CrossRefPubMed

17.

King AD, Mo FK, Yu KH et al (2010) Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response. Eur Radiol 20:2213–2220CrossRefPubMed

18.

King AD, Chow KK, Yu KH et al (2013) Head and neck squamous cell carcinoma: diagnostic performance of diffusion-weighted MR imaging for the prediction of treatment response. Radiology 266:531–538CrossRefPubMed

19.

Partovi S, Kohan AA, Zipp L et al (2014) Hybrid PET/MR imaging in two sarcoma patients - clinical benefits and implications for future trials. Int J Clin Exp Med 7:640–648PubMedPubMedCentral

20.

Boellaard R, Delgado-Bolton R, Oyen WJ et al (2015) FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging 42:328–354CrossRefPubMed

21.

Petralia G, Bonello L, Summers P et al (2011) Intraobserver and interobserver variability in the calculation of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) of breast tumours. Radiol Med 116:466–476CrossRefPubMed

22.

Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9:671–675CrossRefPubMed

23.

Rorden C (2012) dcm2nii ver 12 12. http://www.mccauslandcenter.sc.edu/mricro/mricron. Accessed 15 Sep 2015

24.

Zhang B, Geng J, Nie F, Li X (2015) Primary tumor standardized uptake value predicts survival in head and neck squamous cell carcinoma. Oncol Res Treat 38:45–48CrossRefPubMed

25.

Minn H, Lapela M, Klemi PJ et al (1997) Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer. J Nucl Med 38:1907–1911PubMed

26.

Torizuka T, Tanizaki Y, Kanno T et al (2009) Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer. Am J Roentgenol 192:156–160CrossRef

27.

Minn H, Clavo AC, Grenman R et al (1995) In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous cell carcinoma of the head and neck. J Nucl Med 36:252–258PubMed

28.

Takahashi Y, Oriuchi N, Otake H, Endo K, Murase K (2008) Variability of lesion detectability and standardized uptake value according to the acquisition procedure and reconstruction among five PET scanners. Ann Nucl Med 22:543–548CrossRefPubMed

29.

Chu KP, Murphy JD, La TH et al (2012) Prognostic value of metabolic tumor volume and velocity in predicting head-and-neck cancer outcomes. Int J Radiat Oncol Biol Phys 83:1521–1527CrossRefPubMedPubMedCentral

30.

Hoang JK, Das SK, Choudhury KR, Yoo DS, Brizel DM (2013) Using FDG-PET to measure early treatment response in head and neck squamous cell carcinoma: quantifying intrinsic variability in order to understand treatment-induced change. AJNR Am J Neuroradiol 34:1428–1433CrossRefPubMed

31.

Kolff-Gart AS, Pouwels PJ, Noij DP et al (2015) Diffusion-weighted imaging of the head and neck in healthy subjects: reproducibility of ADC values in different MRI systems and repeat sessions. AJNR Am J Neuroradiol 36:384–390CrossRefPubMed

32.

Becker M, Zaidi H (2014) Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI. Br J Radiol 87:20130677CrossRefPubMedPubMedCentral

33.

Padhani AR, Liu G, Koh DM et al (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia 11:101–125CrossRef

34.

Le Bihan D, Breton E, Lallemand D et al (1988) Separation of diffusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505CrossRefPubMed

35.

Brizel DM, Sibley GS, Prosnitz LR et al (1997) Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38:259–285CrossRef

36.

Stadler P, Becker A, Feldmann HJ et al (1999) Influence of the hypoxic subvolume on the survival of the patients with head and neck cancer. Int J Radiat Oncol Biol Phys 44:749–754CrossRefPubMed

37.

Thoeny HC, Ross BD (2010) Predicting and monitoring cancer treatment response with diffusion-weighted MRI. J Magn Reson Imaging 32:2–16CrossRefPubMedPubMedCentral

38.

Wang K, Ma W, Wang J et al (2012) Tumor-stroma ratio is an independent predictor for survival in esophageal squamous cell carcinoma. J Thorac Oncol 7:1457–1461CrossRefPubMed

39.

De Kruif EM, van Nes JG, van de Velde CJ et al (2011) Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients. Breast Cancer Res Treat 125:687–696CrossRef

40.

Huibers A, Tollenaar RA, v Pelt GW et al (2013) The proportion of tumor-stroma as strong prognosticator for stage II and stage III colon cancer patients: validation in the VICTOR trial. Ann Oncol 24:179–185CrossRef

41.

Koontongkaew S (2013) The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinoma. J Cancer 4:66–83CrossRefPubMedPubMedCentral

42.

Neesse A, Michl P, Frese KK et al (2011) Stromal biology and therapy in pancreatic cancer. Gut 60:861–868CrossRefPubMed

43.

Mueller MM, Fusening NE (2004) Friends or foes - bipolar effects of the tumor stroma in cancer. Nat Rev Cancer 4:839–849CrossRefPubMed

44.

Rothman KJ (1990) No adjustments are needed for multiple comparisons. Epidemiology 1:43–44CrossRefPubMed

45.

Maeda M, Kato H, Sakuma H, Maier SE, Takeda K (2005) Usefulness of the apparent diffusion coefficient in line scan diffusion-weighted imaging for distinguishing between squamous cell carcinomas and malignant lymphomas of the head and neck. AJNR Am J Neuroradiol 26:1186–1192PubMed

46.

Wang J, TakashimaS TF et al (2001) Head and neck lesions: characterization with diffusion-weighted echoplanar MR imaging. Radiology 220:621–630CrossRefPubMed

47.

Reichert M, Ai T, Morelli JN, Nittka M, Attenberger U, Runge VM (2015) Metal artefact reduction in MRI at both 1.5 and 3.0 T using slice encoding for metal artefact correction and view angle tilting. Br J Radiol 88:20140601CrossRefPubMedPubMedCentral

Titel: Combining standardized uptake value of FDG-PET and apparent diffusion coefficient of DW-MRI improves risk stratification in head and neck squamous cell carcinoma
verfasst von: Lorenzo Preda
Giorgio Conte
Luke Bonello
Caterina Giannitto
Laura L. Travaini
Sara Raimondi
Paul E. Summers
Ansarin Mohssen
Daniela Alterio
Maria Cossu Rocca
Chiara Grana
Francesca Ruju
Massimo Bellomi
Publikationsdatum: 10.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 12/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4284-8

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Springer Medizin

Combining standardized uptake value of FDG-PET and apparent diffusion coefficient of DW-MRI improves risk stratification in head and neck squamous cell carcinoma

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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