Introduction
Methods
Study population
Value | Normal range | |
---|---|---|
Serum C3–g/L | 1.30 (0.99–1.41) | 0.82–1.93 |
Serum C4–g/L | 0.26 (0.20–0.30) | 0.15–0.57 |
Serum creatinine–mg/dL | 3.16 (1.48–5.22) | 0.70–1.20 |
eGFR–mL/min/1.73 m2 | 17.25 (8.78–47.65) | > 60 |
CRP–mg/L | 60.50 (19.50–101.15) | ≤ 5.00 |
Female sex–no. (%) | 17 (44.74) | |
Age–years | 66.50 (50.75–74.00) | |
ANCA diagnosis | ||
MPA–no. (%) | 22 (57.89) | |
GPA–no. (%) | 16 (42.11) | |
ANCA subtype | ||
MPO–no. (%) | 22 (57.89) | |
PR3–no. (%) | 16 (42.11) | |
Relapse–no. (%) | 6 (15.79) | |
BVAS–points | 18 (15.00–20.25) | |
KRT within 40 days–no. (%) | 13 (34.21) | |
Death within 40 days–no. (%) | 1 (2.63) | |
Berden class | ||
Sclerotic class–no. (%) | 2 (5.26) | |
Crescentic class–no. (%) | 14 (36.84) | |
Focal class–no. (%) | 19 (50) | |
Mixed class–no. (%) | 3 (7.89) | |
ANCA Renal Risk Score | ||
High risk–no. (%) | 6 (15.79) | |
Intermediate risk–no. (%) | 16 (42.11) | |
Low risk–no. (%) | 16 (42.11) | |
Histopathological lesions | ||
Normal glomeruli–% of total | 49.47 (23.37–73.07) | |
Crescentic glomeruli–% of total | 35.94 (8.17–56.85) | |
Necrotic glomeruli–% of total | 18.34 (5.77–50.27) | |
Sclerotic glomeruli–% of total | 2.82 (0.00–21.11) | |
IF/TA–% | 20.00 (10.00–40.00) |
Renal histopathology
C3 and C4 measurements
Statistical methods
Results
C4 < 0.26 g/L | C4 ≥ 0.26 g/L | p value | |
---|---|---|---|
Serum C3–g/L | 1.18 (0.84–1.40) | 1.32 (1.25–1.44) | 0.0313 |
Serum C4–g/L | 0.20 (0.15–0.22) | 0.30 (0.29–0.37) | < 0.0001 |
Serum creatinine–mg/dL | 3.14 (1.49–5.26) | 3.17 (1.12–4.93) | 0.7347 |
eGFR–mL/min/1.73 m2 | 17.60 (8.40–35.90) | 15.80 (9.60–80.60) | 0.5584 |
CRP–mg/L | 57.40 (16.40–104.00) | 63.60 (19.90–100.20) | 0.8567 |
Female sex–no. (%) | 10 (52.63) | 7 (36.84) | 0.3277 |
Age–years | 69 (61–76) | 55 (49–70) | 0.0105 |
ANCA diagnosis | |||
MPA–no. (%) | 10 (52.63) | 12 (63.16) | |
GPA–no. (%) | 9 (47.37) | 7 (36.84) | 0.5111 |
ANCA subtype | |||
MPO–no. (%) | 9 (47.37) | 13 (68.42) | |
PR3–no. (%) | 10 (52.63) | 6 (31.58) | 0.1888 |
Relapse–no. (%) | 4 (21.05) | 2 (10.53) | 0.3736 |
BVAS–points | 18 (15.00–20.00) | 18 (15–21) | 0.9937 |
KRT within 40 days–no. (%) | 8 (42.11) | 5 (26.32) | 0.3050 |
Death within 40 days–no. (%) | 1 (5.26) | 0 (0.00) | 0.3109 |
Berden class | |||
Sclerotic class–no. (%) | 1 (5.26) | 1 (5.26) | |
Crescentic class–no. (%) | 8 (42.11) | 6 (31.58) | |
Focal class–no. (%) | 9 (47.37) | 10 (52.63) | |
Mixed class–no. (%) | 1 (5.26) | 2 (10.53) | 0.8798 |
ANCA Renal Risk Score | |||
High risk–no. (%) | 3 (15.79) | 3 (15.79) | |
Intermediate risk–no. (%) | 9 (47.37) | 7 (36.84) | |
Low risk–no. (%) | 7 (36.84) | 9 (47.37) | 0.7788 |
Histopathological lesions | |||
Normal glomeruli–% of total | 48.94 (24.49–70.59) | 54.35 (20.00–83.33) | 0.8455 |
Crescentic glomeruli–% of total | 37.50 (10.00–55.56) | 33.33 (0.00–60.71) | 0.5283 |
Necrotic glomeruli–% of total | 12.50 (0.00–55.56) | 28.00 (9.09–46.67) | 0.4359 |
Sclerotic glomeruli–% of total | 9.09 (0.00–21.28) | 0.00 (0.00–18.18) | 0.3379 |
IF/TA–% | 20.00 (10.00–40.00) | 20.00 (5.00–40.00) | 0.9361 |
C3 < 1.3 g/L | C3 ≥ 1.3 g/L | p value | |
---|---|---|---|
Serum C3–g/L | 1.02 (0.81–1.20) | 1.41 (1.32–1.55) | < 0.0001 |
Serum C4–g/L | 0.22 (0.15–0.31) | 0.29 (0.22–0.30) | 0.0706 |
Serum creatinine–mg/dL | 4.72 (1.75–7.27) | 2.91 (0.87–4.14) | 0.0088 |
eGFR–mL/min/1.73 m2 | 9.80 (6.90–27.90) | 24.10 (13.20–89.90) | 0.0121 |
CRP–mg/L | 57.40 (10.80–89.00) | 63.80 (30.30–109.30) | 0.3432 |
Female sex–no. (%) | 8 (42.11) | 9 (47.37) | 0.7442 |
Age–years | 69 (55–76) | 60 (50–70) | 0.1882 |
ANCA diagnosis | |||
MPA–no. (%) | 12 (63.2) | 10 (52.63) | |
GPA–no. (%) | 7 (36.8) | 9 (47.37) | 0.5111 |
ANCA subtype | |||
MPO–no. (%) | 12 (63.16) | 10 (52.63) | |
PR3–no. (%) | 7 (36.84) | 9 (47.37) | 0.5111 |
Relapse–no. (%) | 4 (21.05) | 2 (10.53) | 0.3736 |
BVAS–points | 18 (15.00–20.00) | 18 (15–21) | 0.9937 |
KRT within 40 days–no. (%) | 10 (52.63) | 3 (15.79) | 0.0167 |
Death within 40 days–no. (%) | 1 (5.26) | 0 (0.00) | 0.3109 |
Berden class | |||
Sclerotic class–no. (%) | 2 (10.53) | 0 (0.00) | |
Crescentic class–no. (%) | 7 (36.84) | 7 (36.84) | |
Focal class–no. (%) | 8 (42.11) | 11 (57.89) | |
Mixed class–no. (%) | 2 (10.53) | 1 (5.26) | 0.4223 |
ANCA Renal Risk Score | |||
High risk–no. (%) | 5 (26.31) | 1 (5.26) | |
Intermediate risk–no. (%) | 7 (36.84) | 9 (47.37) | |
Low risk–no. (%) | 7 (36.84) | 9 (47.37) | 0.2053 |
Histopathological lesions | |||
Normal glomeruli–% of total | 42.42 (11.11–70.59) | 56.25 (35.29–83.33) | 0.1280 |
Crescentic glomeruli–% of total | 37.50 (12.50–54.55) | 34.38 (0.00–60.71) | 0.5475 |
Necrotic glomeruli–% of total | 15.15 (0.00–46.67) | 28.00 (9.09–51.06) | 0.3701 |
Sclerotic glomeruli–% of total | 9.09 (0.00–29.41) | 0.00 (0.00–12.50) | 0.0646 |
IF/TA–% | 20.00 (15.00–40.00) | 20.00 (5.00–40.00) | 0.3246 |