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01.05.2015 | Original Article

Comparison between adults and children with Henoch–Schönlein purpura nephritis

verfasst von: Shan Lu, Dong Liu, Jing Xiao, Wenming Yuan, Xiaoyang Wang, Xiaoxue Zhang, Jin Zhang, Zhangsuo Liu, Zhanzheng Zhao

Erschienen in: Pediatric Nephrology | Ausgabe 5/2015

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Abstract

Background

Henoch–Schönlein purpura (HSP) mainly affects children, but age is also thought to be an important prognostic factor. Kidney involvement is a major cause of mortality in HSP patients. The purpose of this study was to analyze the clinicopathological correlations between adults and children.

Methods

A total of 208 children and 75 adult patients with HSP nephritis (HSPN) were evaluated. All patients underwent a renal biopsy.

Results

Extra-renal symptoms (arthritis and abdominal pain) were more common in the pediatric patient group than in the adult group (P < 0.05), but renal symptoms (edema and hypertension) were relatively rare (P < 0.05). A significant positive correlation was noted between pathological type and clinical type (P < 0.01). Pathological activity was positively related to renal failure, abdominal pain, microscopic hematuria, hypertension, and proteinuria (P < 0.05). Pathological chronicity was positively associated with age, duration of follow-up since the onset of palpable purpura, renal failure, lower extremity edema, hypertension, and proteinuria (P < 0.05).

Conclusions

Various clinicopathological differences exist between children and adults with HSPN. Massive proteinuria, renal failure, and abdominal pain usually correlated with severe pathology. Renal biopsy should be performed in both pediatric and adult HSPN patients with repeated hematuria and/or consistent minimal proteinuria.

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Titel: Comparison between adults and children with Henoch–Schönlein purpura nephritis
verfasst von: Shan Lu
Dong Liu
Jing Xiao
Wenming Yuan
Xiaoyang Wang
Xiaoxue Zhang
Jin Zhang
Zhangsuo Liu
Zhanzheng Zhao
Publikationsdatum: 01.05.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 5/2015
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-3016-z

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Comparison between adults and children with Henoch–Schönlein purpura nephritis