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Erschienen in: Abdominal Radiology 8/2021

26.03.2021 | Hepatobiliary

Comparison of diffusion-weighted imaging and MR elastography in staging liver fibrosis: a meta-analysis

verfasst von: Weon Jang, Seongil Jo, Ji Soo Song, Hong Pil Hwang, Seong-Hun Kim

Erschienen in: Abdominal Radiology | Ausgabe 8/2021

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Abstract

Purpose

To compare the diagnostic performance of diffusion-weighted imaging (DWI), gradient-recalled echo-based magnetic resonance elastography (GRE-MRE), and spin-echo echo-planar imaging-based MRE (SE-EPI-MRE) in liver fibrosis staging.

Methods

A systematic literature search was done to collect studies on the performance of DWI, GRE-MRE, and SE-EPI-MRE for diagnosing liver fibrosis. Pooled sensitivity, specificity, diagnostic odds ratio, positive and negative likelihood ratio, and a summary receiver operating characteristic (ROC) curve were estimated with a bivariate random effects model. Subgroup analyses on various study characteristics were performed.

Results

Sixty studies with a total of 6620 patients were included in the meta-analysis. Pooled sensitivity and specificity of GRE-MRE and SE-EPI-MRE showed high diagnostic accuracy and did not differ significantly. The area under the summary ROC curve for all stages of fibrosis differed significantly between DWI (0.83–0.88) and either GRE-MRE (0.95–0.97) or SE-EPI-MRE (0.95–0.99). Substantial heterogeneity was detected for all three imaging methods.

Conclusions

Both GRE-MRE and SE-EPI-MRE are highly accurate for detection of each liver fibrosis stage, with high potential to replace liver biopsy. Although DWI had a moderate accuracy in distinguishing liver fibrosis, it could be regarded as an alternative to MRE, since it is widely available and easily implemented in routine liver MRI.
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Metadaten
Titel
Comparison of diffusion-weighted imaging and MR elastography in staging liver fibrosis: a meta-analysis
verfasst von
Weon Jang
Seongil Jo
Ji Soo Song
Hong Pil Hwang
Seong-Hun Kim
Publikationsdatum
26.03.2021
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 8/2021
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-021-03055-2

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