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Abdominal Radiology
Erschienen in: Abdominal Radiology 2/2017

27.09.2016

Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis

verfasst von: Hanyu Jiang, Jie Chen, Ronghui Gao, Zixing Huang, Mingpeng Wu, Bin Song

Erschienen in: Abdominal Radiology | Ausgabe 2/2017

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Abstract

Purpose

A meta-analysis was performed to assess the diagnostic performance of diffusion-weighted imaging (DWI) in liver fibrosis (LF) staging.

Methods

We conducted a comprehensive literature search to identify relevant articles. Diagnostic data were extracted for each METAVIR fibrosis stage (F0–F4). A bivariate binomial model was used to combine sensitivities and specificities. Summary receiver operating characteristics (SROC) curves were performed and areas under SROC curve (AUC) were calculated to indicate diagnostic accuracies. Subgroup analyses were performed between different study characteristics.

Results

Twelve studies met the inclusion criteria for LF ≥F1, 16 for ≥F2, 18 for ≥F3, and 12 for F4. AUCs of DWI were 0.8554, 0.8770, 0.8836, and 0.8596 for ≥F1, ≥F2, ≥F3, and F4, respectively. Subgroup analyses showed that for LF ≥F2 and ≥F3, maximal b values (b max) ≥ 800 s/mm2 performed significantly better than b max < 800 s/mm2. The diagnostic accuracies of 3.0 T and intravoxel incoherent motion (IVIM)-DWI were significantly higher than those of 1.5 T and conventional DWI for diagnosing liver cirrhosis (F4).

Conclusions

DWI is a reliable noninvasive technique with good diagnostic accuracy for LF staging. Using b max ≥ 800 s/mm2, high-field strength (3.0 T) and IVIM-DWI can optimize the diagnostic performance of DWI.
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Metadaten
Titel
Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis
verfasst von
Hanyu Jiang
Jie Chen
Ronghui Gao
Zixing Huang
Mingpeng Wu
Bin Song
Publikationsdatum
27.09.2016
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 2/2017
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-016-0913-6

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