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Erschienen in: CardioVascular and Interventional Radiology 10/2018

05.06.2018 | Clinical Investigation

Complex Biliary Leaks: Effectiveness of Percutaneous Radiological Treatment Compared to Simple Leaks in 101 Patients

verfasst von: Charles Mastier, Pierre-Jean Valette, Mustapha Adham, Jean-Yves Mabrut, Olivier Glehen, Thierry Ponchon, Pascal Rousset, Agnès Rode

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 10/2018

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Abstract

Purpose

To assess the effectiveness of percutaneous radiological treatment for complex biliary leaks compared to simple biliary leaks.

Materials and Methods

We retrospectively analyzed 101 percutaneous treatments for bile leak performed from January 1994 to January 2012. Sixty (59%) bile leaks were classified as simple and 41 (41%) as complex based on a morphological classification that considered eight types of biliary wound on cholangiography images. The main treatment was percutaneous transhepatic biliary drainage (PTBD), and additional procedures were performed when required. The technical success of PTBD, leak healing, and recurrence, as well as complication rates were compared between the simple and complex leak groups.

Results

Technical success of PTBP was achieved in 94/101 (93%) patients: 59/60 (98%) for simple leaks and 35/41 (85%) for complex leaks (p = 0.017). When PTBD internalization was achieved, leak healing was obtained in 80/94 (85%) patients: 52/59 (88%) for simple leaks and 28/35 (80%) for complex leaks (p = 0.37), with additional percutaneous procedures required in five patients with simple leaks and 13 patients with complex leaks (p = 0.001). There was no recurrence in 75/80 (94%) patients: 50/52 (96%) for simple leaks and 25/28 (89%) for complex leaks (p = 0.34). Major complications occurred in 28/101 (28%) patients: 16/59 (27%) for simple leaks and 12/41 (29%) for complex leaks (p = 0.82).

Conclusion

Once PTBD internalization is achieved, complex leaks heal as well as simple leaks.
Literatur
1.
Zurück zum Zitat Thompson CM, Saad NE, Quazi RR, Darcy MD, Picus DD, Menias CO. Management of iatrogenic bile duct injuries: role of the interventional radiologist. Radiographics. 2013;33:117–34.CrossRefPubMed Thompson CM, Saad NE, Quazi RR, Darcy MD, Picus DD, Menias CO. Management of iatrogenic bile duct injuries: role of the interventional radiologist. Radiographics. 2013;33:117–34.CrossRefPubMed
2.
Zurück zum Zitat Connor S, Garden OJ. Bile duct injury in the era of laparoscopic cholecystectomy. Br J Surg. 2006;93:158–68.CrossRefPubMed Connor S, Garden OJ. Bile duct injury in the era of laparoscopic cholecystectomy. Br J Surg. 2006;93:158–68.CrossRefPubMed
3.
Zurück zum Zitat Chang JM, Lee JM, Suh KS, Yi NJ, Kim YT, Kim SH, et al. Biliary complications in living donor liver transplantation: imaging findings and the roles of interventional procedures. Cardiovasc Intervent Radiol. 2005;28:756–67.CrossRefPubMed Chang JM, Lee JM, Suh KS, Yi NJ, Kim YT, Kim SH, et al. Biliary complications in living donor liver transplantation: imaging findings and the roles of interventional procedures. Cardiovasc Intervent Radiol. 2005;28:756–67.CrossRefPubMed
4.
Zurück zum Zitat De Castro SMM, Kuhlmann KFD, Busch ORC, van Delden OM, Laméris JS, van Gulik TM, et al. Incidence and management of biliary leakage after hepaticojejunostomy. J Gastrointest Surg. 2005;9:1163–71.CrossRefPubMed De Castro SMM, Kuhlmann KFD, Busch ORC, van Delden OM, Laméris JS, van Gulik TM, et al. Incidence and management of biliary leakage after hepaticojejunostomy. J Gastrointest Surg. 2005;9:1163–71.CrossRefPubMed
5.
Zurück zum Zitat Chiche L, Letoublon C. Traitement des complications de la cholécystectomie. EMC Tech Chir Appar Dig. 2010;5(1–20):6. Chiche L, Letoublon C. Traitement des complications de la cholécystectomie. EMC Tech Chir Appar Dig. 2010;5(1–20):6.
6.
Zurück zum Zitat Sandha GS, Bourke MJ, Haber GB, Kortan PP. Endoscopic therapy for bile leak based on a new classification: results in 207 patients. Gastrointest Endosc. 2004;60:567–74.CrossRefPubMed Sandha GS, Bourke MJ, Haber GB, Kortan PP. Endoscopic therapy for bile leak based on a new classification: results in 207 patients. Gastrointest Endosc. 2004;60:567–74.CrossRefPubMed
7.
Zurück zum Zitat Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of interventional radiology clinical practice guidelines. J Vasc Interv Radiol. 2003;14:S199–202.CrossRefPubMed Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of interventional radiology clinical practice guidelines. J Vasc Interv Radiol. 2003;14:S199–202.CrossRefPubMed
8.
Zurück zum Zitat Lau W-Y, Lai ECH. Classification of iatrogenic bile duct injury. Hepatobiliary Pancreat Dis Int HBPD INT. 2007;6:459–63.PubMed Lau W-Y, Lai ECH. Classification of iatrogenic bile duct injury. Hepatobiliary Pancreat Dis Int HBPD INT. 2007;6:459–63.PubMed
9.
Zurück zum Zitat Fonio P, Cassinis MC, Rapellino A, Righi D, Gandini G. Interventional radiology in the treatment of early postoperative biliary complications. Radiol Med. 2013;118:386–400.CrossRefPubMed Fonio P, Cassinis MC, Rapellino A, Righi D, Gandini G. Interventional radiology in the treatment of early postoperative biliary complications. Radiol Med. 2013;118:386–400.CrossRefPubMed
10.
Zurück zum Zitat Ernst O, Sergent G, Mizrahi D, Delemazure O, L’Herminé C. Biliary leaks: treatment by means of percutaneous transhepatic biliary drainage1. Radiology. 1999;211:345–8.CrossRefPubMed Ernst O, Sergent G, Mizrahi D, Delemazure O, L’Herminé C. Biliary leaks: treatment by means of percutaneous transhepatic biliary drainage1. Radiology. 1999;211:345–8.CrossRefPubMed
11.
Zurück zum Zitat Dumonceau J-M, Tringali A, Blero D, Devière J, Laugiers R, Heresbach D, et al. Biliary stenting: indications, choice of stents and results: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy. 2012;44:277–98.CrossRefPubMed Dumonceau J-M, Tringali A, Blero D, Devière J, Laugiers R, Heresbach D, et al. Biliary stenting: indications, choice of stents and results: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy. 2012;44:277–98.CrossRefPubMed
12.
Zurück zum Zitat Cozzi G, Severini A, Civelli E, Milella M, Pulvirenti A, Salvetti M, et al. Percutaneous transhepatic biliary drainage in the management of postsurgical biliary leaks in patients with nondilated intrahepatic bile ducts. Cardiovasc Intervent Radiol. 2006;29:380–8.CrossRefPubMed Cozzi G, Severini A, Civelli E, Milella M, Pulvirenti A, Salvetti M, et al. Percutaneous transhepatic biliary drainage in the management of postsurgical biliary leaks in patients with nondilated intrahepatic bile ducts. Cardiovasc Intervent Radiol. 2006;29:380–8.CrossRefPubMed
13.
Zurück zum Zitat Kühn JP, Busemann A, Lerch MM, Heidecke CD, Hosten N, Puls R. Percutaneous biliary drainage in patients with nondilated intrahepatic bile ducts compared with patients with dilated intrahepatic bile ducts. Am J Roentgenol. 2010;195:851–7.CrossRef Kühn JP, Busemann A, Lerch MM, Heidecke CD, Hosten N, Puls R. Percutaneous biliary drainage in patients with nondilated intrahepatic bile ducts compared with patients with dilated intrahepatic bile ducts. Am J Roentgenol. 2010;195:851–7.CrossRef
14.
Zurück zum Zitat Lee W, Kim GC, Kim JY, Baik SK, Lee HJ, Kim HJ, et al. Ultrasound and fluoroscopy guided percutaneous transhepatic biliary drainage in patients with nondilated bile ducts. Abdom Imaging. 2008;33:555–9.CrossRefPubMed Lee W, Kim GC, Kim JY, Baik SK, Lee HJ, Kim HJ, et al. Ultrasound and fluoroscopy guided percutaneous transhepatic biliary drainage in patients with nondilated bile ducts. Abdom Imaging. 2008;33:555–9.CrossRefPubMed
15.
Zurück zum Zitat L’Hermine C, Ernst O, Delemazure O, Sergent G. Arterial complications of percutaneous transhepatic biliary drainage. Cardiovasc Intervent Radiol. 1996;19:160–4.CrossRefPubMed L’Hermine C, Ernst O, Delemazure O, Sergent G. Arterial complications of percutaneous transhepatic biliary drainage. Cardiovasc Intervent Radiol. 1996;19:160–4.CrossRefPubMed
16.
Zurück zum Zitat Choi SH, Gwon DI, Ko G-Y, Sung K-B, Yoon H-K, Shin JH, et al. Hepatic arterial injuries in 3110 patients following percutaneous transhepatic biliary drainage. Radiology. 2011;261:969–75.CrossRefPubMed Choi SH, Gwon DI, Ko G-Y, Sung K-B, Yoon H-K, Shin JH, et al. Hepatic arterial injuries in 3110 patients following percutaneous transhepatic biliary drainage. Radiology. 2011;261:969–75.CrossRefPubMed
17.
Zurück zum Zitat Brijbassie A, Stevens PD, Sethi A, Sejpal DV, Raijman I, Loren DE, et al. T1519: Use of Fully Covered Self Expanding Metal Stents (FCSEMS) in the Management of Benign Biliary Diseases (BBD). Gastrointest Endosc. 2010;71:298.CrossRef Brijbassie A, Stevens PD, Sethi A, Sejpal DV, Raijman I, Loren DE, et al. T1519: Use of Fully Covered Self Expanding Metal Stents (FCSEMS) in the Management of Benign Biliary Diseases (BBD). Gastrointest Endosc. 2010;71:298.CrossRef
18.
Zurück zum Zitat Gwon DI, Ko G-Y, Sung K-B, Kim JH, Yoon H-K. Percutaneous transhepatic treatment of postoperative bile leaks: prospective evaluation of retrievable covered stent. J Vasc Interv Radiol JVIR. 2011;22:75–83.CrossRefPubMed Gwon DI, Ko G-Y, Sung K-B, Kim JH, Yoon H-K. Percutaneous transhepatic treatment of postoperative bile leaks: prospective evaluation of retrievable covered stent. J Vasc Interv Radiol JVIR. 2011;22:75–83.CrossRefPubMed
19.
Zurück zum Zitat Grasso RF, Luppi G, Giurazza F, Del Vescovo R, Faiella E, Cazzato RL, et al. Bile leak refilling an intrahepatic biloma managed with AMPLATZER vascular plug. J Vasc Interv Radiol JVIR. 2011;22:1637–8.CrossRefPubMed Grasso RF, Luppi G, Giurazza F, Del Vescovo R, Faiella E, Cazzato RL, et al. Bile leak refilling an intrahepatic biloma managed with AMPLATZER vascular plug. J Vasc Interv Radiol JVIR. 2011;22:1637–8.CrossRefPubMed
20.
Zurück zum Zitat Vu DN, Strub WM, Nguyen PM. Biliary duct ablation with N-butyl cyanoacrylate. J Vasc Interv Radiol JVIR. 2006;17:63–9.CrossRefPubMed Vu DN, Strub WM, Nguyen PM. Biliary duct ablation with N-butyl cyanoacrylate. J Vasc Interv Radiol JVIR. 2006;17:63–9.CrossRefPubMed
21.
Zurück zum Zitat Kyokane T, Nagino M, Sano T, Nimura Y. Ethanol ablation for segmental bile duct leakage after hepatobiliary resection. Surgery. 2002;131:111–3.CrossRefPubMed Kyokane T, Nagino M, Sano T, Nimura Y. Ethanol ablation for segmental bile duct leakage after hepatobiliary resection. Surgery. 2002;131:111–3.CrossRefPubMed
Metadaten
Titel
Complex Biliary Leaks: Effectiveness of Percutaneous Radiological Treatment Compared to Simple Leaks in 101 Patients
verfasst von
Charles Mastier
Pierre-Jean Valette
Mustapha Adham
Jean-Yves Mabrut
Olivier Glehen
Thierry Ponchon
Pascal Rousset
Agnès Rode
Publikationsdatum
05.06.2018
Verlag
Springer US
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 10/2018
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-018-2005-1

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