Contact anaphylaxis after application of an herbal ointment containing phenonip

Excerpt

Contact urticaria und contact urticaria syndrome are characterized by the immediate development of itchy flares and wheals [1]. Contact urticaria may turn into contact anaphylaxis and may occur after topical application of cosmetics, medical ointments, hair dyes, fresh food, metals, and occupational substances such as cow dander, natural rubber latex, or flour, grains, and feed [1, 2]. Contact anaphylaxis as a form of hypersensitivity reaction is rare but may represent a medical emergency. Epidemiological data for contact anaphylaxis are limited and based on single case reports or small case series. Possibly, these reactions occur more often than estimated. The pathomechanism underlying contact urticaria syndrome and contact anaphylaxis can be IgE-mediated, but most forms seem to results from non-immunological reactions due to the release of vaso genic mediators [1]. Atopy seems to be a relevant risk factor for the development of contact urticaria, contact urticarial syndrome, and contact anaphylaxis [1]. …