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Inflammation Research
Erschienen in: Inflammation Research 12/2016

09.09.2016 | Original Research Paper

Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo

verfasst von: Ji-ming Yin, Li-bo Sun, Jia-sheng Zheng, Xin-xin Wang, De-xi Chen, Ning Li

Erschienen in: Inflammation Research | Ausgabe 12/2016

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Abstract

Objective

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. Radiofrequency ablation (RFA) is currently performed widely for managing HCC. RFA treatment causes damage around the ablation. Trientine dihydrochloride has been used to reduce the copper in liver.

Methods

The rats were treated with trientine dihydrochloride for 5 days before liver RFA. Liver function, copper concentration, inflammation biomarkers and MDA, SOD were analyzed after RFA treatment for 2 h, 2 and 5 days.

Results

The results indicated that trientine dihydrochloride reduced the copper in plasma and liver tissue significantly. And trientine dihydrochloride significantly inhibited RFA-induced inflammatory gene expression in liver. Similar inhibitory effects of trientine dihydrochloride were observed on ROS-induced malondialdehyde production in liver tissues.

Conclusion

These results suggest that pre-treatment with the selective copper chelator trientine dihydrochloride can inhibit inflammatory response effectively during and after liver RFA in vivo. Chelation of copper to a lower level before liver RFA may be a novel strategy to prevent or ameliorate inflammatory responses in liver induced by RFA and to protect the parenchyma tissues in liver during and after RFA in HCC patients.
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Literatur
1.
Zhu AX. Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be? Oncologist. 2006;11:790–800.CrossRefPubMed
2.
3.
Foster J, Black J, LeVea C, Khoury T, Kuvshinoff B, Javle M, et al. COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival. Ann Surg Oncol. 2007;14:752–8.CrossRefPubMed
4.
Liang P, Wang Y. Microwave ablation of hepatocellular carcinoma. Oncology. 2007;72(Suppl 1):124–31.CrossRefPubMed
5.
Cho YK, Kim JK, Kim WT, Chung JW. Hepatic resection versus radiofrequency ablation for very early stage hepatocellular carcinoma: a Markov model analysis. Hepatology. 2010;51:1284–90.CrossRefPubMed
6.
Rust C, Gores GJ. Locoregional management of hepatocellular carcinoma. Surgical and ablation therapies. Clin Liver Dis. 2001;5:161–73.CrossRefPubMed
7.
Lee WS, Yun SH, Chun HK, Lee WY, Kim SJ, Choi SH, et al. Clinical outcomes of hepatic resection and radiofrequency ablation in patients with solitary colorectal liver metastasis. J Clin Gastroenterol. 2008;42:945–9.CrossRefPubMed
8.
Mulier S, Ruers T, Jamart J, Michel L, Marchal G, Ni Y. Radiofrequency ablation versus resection for resectable colorectal liver metastases: time for a randomized trial? An update. Dig Surg. 2008;25:445–60.CrossRefPubMed
9.
Curley SA, Izzo F, Ellis LM, Vauthey JN, Vallone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg. 2000;232:381–91.CrossRefPubMedPubMedCentral
10.
Adam R, Hagopian EJ, Linhares M, Krissat J, Savier E, Azoulay D, et al. A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignancies. Arch Surg. 2002;137:1332–9 (discussion 1340).CrossRefPubMed
11.
Elias D, Baton O, Sideris L, Boige V, Malka D, Liberale G, et al. Hepatectomy plus intraoperative radiofrequency ablation and chemotherapy to treat technically unresectable multiple colorectal liver metastases. J Surg Oncol. 2005;90:36–42.CrossRefPubMed
12.
Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239:818–25 (discussion 825–7).CrossRefPubMedPubMedCentral
13.
Pawlik TM, Izzo F, Cohen DS, Morris JS, Curley SA. Combined resection and radiofrequency ablation for advanced hepatic malignancies: results in 172 patients. Ann Surg Oncol. 2003;10:1059–69.CrossRefPubMed
14.
Shiina S, Teratani T, Obi S, Sato S, Tateishi R, Fujishima T, et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology. 2005;129:122–30.CrossRefPubMed
15.
Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol. 2008;48(Suppl 1):S20–37.CrossRefPubMed
16.
Lencioni R, Crocetti L. Local-regional treatment of hepatocellular carcinoma. Radiology. 2012;262:43–58.CrossRefPubMed
17.
Zhu AX, Salem R. Combining transarterial chemoembolization with radiofrequency ablation for hepatocellular carcinoma: one step forward? J Clin Oncol Off J Am Soc Clin Oncol. 2013;31:406–8.CrossRef
18.
Mulier S, Mulier P, Ni Y, Miao Y, Dupas B, Marchal G, et al. Complications of radiofrequency coagulation of liver tumours. Br J Surg. 2002;89:1206–22.CrossRefPubMed
19.
Selzer E, Grah A, Heiduschka G, Kornek G, Thurnher D. Primary radiotherapy or postoperative radiotherapy in patients with head and neck cancer: comparative analysis of inflammation-based prognostic scoring systems. Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft [et al]. 2015;191:486–94.CrossRef
20.
Aurello P, Tierno SM, Berardi G, Tomassini F, Magistri P, D’Angelo F, et al. Value of preoperative inflammation-based prognostic scores in predicting overall survival and disease-free survival in patients with gastric cancer. Ann Surg Oncol. 2014;21:1998–2004.CrossRefPubMed
21.
Huang G, Lai EC, Lau WY, Zhou WP, Shen F, Pan ZY, et al. Posthepatectomy HBV reactivation in hepatitis B-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low HBV-DNA levels. Ann Surg. 2013;257:490–505.CrossRefPubMed
22.
Dai CX, Gao Q, Qiu SJ, Ju MJ, Cai MY, Xu YF, et al. Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery. BMC Cancer. 2009;9:418.CrossRefPubMedPubMedCentral
23.
Gulec S, Collins JF. Molecular mediators governing iron-copper interactions. Ann Rev Nutr. 2014;34:95–116.CrossRef
24.
Badding MA, Fix NR, Antonini JM, Leonard SS. A comparison of cytotoxicity and oxidative stress from welding fumes generated with a new nickel-, copper-based consumable versus mild and stainless steel-based welding in RAW 264.7 mouse macrophages. PloS One. 2014;9:e101310.CrossRefPubMedPubMedCentral
25.
Gupte A, Mumper RJ. Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev. 2009;35:32–46.CrossRefPubMed
26.
Mitra S, Keswani T, Ghosh N, Goswami S, Datta A, Das S, et al. Copper induced immunotoxicity promote differential apoptotic pathways in spleen and thymus. Toxicology. 2013;306:74–84.CrossRefPubMed
27.
28.
Linder MC. The relationship of copper to DNA damage and damage prevention in humans. Mutat Res. 2012;733:83–91.CrossRefPubMed
29.
Harders H, Cohnen E. Preparation of and clinical experiences with trien for the treatment of Wilson’s disease in absolute intolerance of d-penicillamine. Proc R Soc Med. 1977;70(Suppl 3):10–2.PubMedPubMedCentral
30.
Walshe JM. The management of Wilson’s disease with trienthylene tetramine 2HC1 (Trien 2HC1). Prog Clin Biol Res. 1979;34:271–80.PubMed
31.
Walshe JM. Treatment of Wilson’s disease with trientine (triethylene tetramine) dihydrochloride. Lancet. 1982;1:643–7.CrossRefPubMed
32.
Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, et al. Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 2014;509:492–6.CrossRefPubMedPubMedCentral
33.
Fu S, Hou MM, Wheler J, Hong D, Naing A, Tsimberidou A, et al. Exploratory study of carboplatin plus the copper-lowering agent trientine in patients with advanced malignancies. Invest New Drugs. 2014;32:465–72.CrossRefPubMed
34.
Zhang L, Ward ML, Phillips AR, Zhang S, Kennedy J, Barry B, et al. Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats. Cardiovasc Diabetol. 2013;12:123.CrossRefPubMedPubMedCentral
35.
Cui JZ, Wang XF, Hsu L, Matsubara JA. Inflammation induced by photocoagulation laser is minimized by copper chelators. Lasers Med Sci. 2009;24:653–7.CrossRefPubMed
36.
Minami Y, Nishida N, Kudo M. Therapeutic response assessment of RFA for HCC: contrast-enhanced US, CT and MRI. World J Gastroenterol WJG. 2014;20:4160–6.CrossRefPubMed
37.
Housset B. Role of free radicals in inflammation. Rhinol Suppl. 1988;5:17–22.PubMed
38.
Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med. 1995;18:775–94.CrossRefPubMed
39.
Ushio-Fukai M, Alexander RW. Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase. Mol Cell Biochem. 2004;264:85–97.CrossRefPubMed
40.
Karaiskos T, Tomos P, Asouhidou I, Nikiteas N, Kontakiotis T, Papalois A. Oxidative and pre-inflammatory stress in wedge resection of pulmonary parenchyma using the radiofrequency ablation technique in a swine model. J Cardiothorac Surg. 2012;7:7.CrossRefPubMedPubMedCentral
41.
Ziraldo C, Vodovotz Y, Namas RA, Almahmoud K, Tapias V, Mi Q, et al. Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. PLoS One. 2013;8:e79804.CrossRefPubMedPubMedCentral
42.
Yoshii J, Yoshiji H, Kuriyama S, Ikenaka Y, Noguchi R, Okuda H, et al. The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells. Int J Cancer. 2001;94:768–73.CrossRefPubMed
Metadaten
Titel
Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo
verfasst von
Ji-ming Yin
Li-bo Sun
Jia-sheng Zheng
Xin-xin Wang
De-xi Chen
Ning Li
Publikationsdatum
09.09.2016
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 12/2016
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-016-0986-2

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