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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 8/2014

01.08.2014 | Refractive Surgery

Corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx smile by Scheimpflug-based dynamic tonometry

verfasst von: Iben Bach Pedersen, Sashia Bak-Nielsen, Anders Højslet Vestergaard, Anders Ivarsen, Jesper Hjortdal

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 8/2014

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Abstract

Purpose

To evaluate corneal biomechanical properties after LASIK, ReLEx flex, and the flap-free procedure ReLEx smile by Scheimpflug-based dynamic tonometry (Corvis ST) and non-contact differential tonometry (Ocular Response Analyzer, ORA).

Methods

Patients treated for high myopia (−10.5 to −5.5 diopters, spherical equivalent refraction) more than one year previously at Aarhus University Hospital were included. Treatments comprised LASIK (35 eyes), ReLEx flex (31 eyes), and ReLEx smile (29 eyes). A control group included 31 healthy eyes. Cornea-compensated IOP (IOPcc), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured with ORA. Corneal applanation and deformation were registered with Corvis ST during an air-pulse.

Results

Multiple linear regression analysis showed that CH and CRF were significantly lower after all keratorefractive procedures compared to healthy controls (p < 0.05). No significant differences were observed in CH or CRF between the keratorefractive groups. Corvis ST showed no differences in radius at highest concavity (HC radius), time until first applanation (A1 Time), time until second applanation (A2 Time), and deflection length at highest concavity (HC deflection length) between groups. LASIK treated eyes had significantly shorter time until highest concavity than eyes treated with ReLEx smile (HC Time, p = 0.01). The A1 deflection length was significantly shorter in the keratorefractive groups compared to the healthy controls (p < 0.05).

Conclusions

Keratorefrative procedures alter the corneal biomechanical properties with regard to corneal hysteresis and corneal resistant factor. The flap-based LASIK and ReLEx flex and the flap-free ReLEx smile result in similar reduction in corneal biomechanics when evaluated by Corvis ST and ORA.
Literatur
1.
Zurück zum Zitat Gazieva L, Beer MH, Nielsen K, Hjortdal J (2011) A retrospective comparison of efficacy and safety of 680 consecutive lasik treatments for high myopia performed with two generations of flying-spot excimer lasers. Acta Ophthalmol 89:729–733PubMedCrossRef Gazieva L, Beer MH, Nielsen K, Hjortdal J (2011) A retrospective comparison of efficacy and safety of 680 consecutive lasik treatments for high myopia performed with two generations of flying-spot excimer lasers. Acta Ophthalmol 89:729–733PubMedCrossRef
2.
Zurück zum Zitat Wang JC, Hufnagel TJ, Buxton DF (2003) Bilateral keratectasia after unilateral laser in situ keratomileusis: a retrospective diagnosis of ectatic corneal disorder. J Cataract Refract Surg 29:2015–2018PubMedCrossRef Wang JC, Hufnagel TJ, Buxton DF (2003) Bilateral keratectasia after unilateral laser in situ keratomileusis: a retrospective diagnosis of ectatic corneal disorder. J Cataract Refract Surg 29:2015–2018PubMedCrossRef
3.
Zurück zum Zitat Geggel HS, Talley AR (1999) Delayed onset keratectasia following laser in situ keratomileusis. J Cataract Refract Surg 25:582–586PubMedCrossRef Geggel HS, Talley AR (1999) Delayed onset keratectasia following laser in situ keratomileusis. J Cataract Refract Surg 25:582–586PubMedCrossRef
4.
Zurück zum Zitat Joo CK, Kim TG (2000) Corneal ectasia detected after laser in situ keratomileusis for correction of less than −12 diopters of myopia. J Cataract Refract Surg 26:292–295PubMedCrossRef Joo CK, Kim TG (2000) Corneal ectasia detected after laser in situ keratomileusis for correction of less than −12 diopters of myopia. J Cataract Refract Surg 26:292–295PubMedCrossRef
5.
Zurück zum Zitat Ou RJ, Shaw EL, Glasgow BJ (2002) Keratectasia after laser in situ keratomileusis (LASIK): evaluation of the calculated residual stromal bed thickness. Am J Ophthalmol 134:771–773PubMedCrossRef Ou RJ, Shaw EL, Glasgow BJ (2002) Keratectasia after laser in situ keratomileusis (LASIK): evaluation of the calculated residual stromal bed thickness. Am J Ophthalmol 134:771–773PubMedCrossRef
6.
Zurück zum Zitat Parmar D, Claoue C (2004) Keratectasia following excimer laser photorefractive keratectomy. Acta Ophthalmol Scand 82:102–105PubMedCrossRef Parmar D, Claoue C (2004) Keratectasia following excimer laser photorefractive keratectomy. Acta Ophthalmol Scand 82:102–105PubMedCrossRef
7.
Zurück zum Zitat Teichmann KD (2004) Bilateral keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 30:2257–2258PubMedCrossRef Teichmann KD (2004) Bilateral keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 30:2257–2258PubMedCrossRef
8.
Zurück zum Zitat Tervo TM (2001) Iatrogenic keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 27:490–491PubMedCrossRef Tervo TM (2001) Iatrogenic keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 27:490–491PubMedCrossRef
9.
Zurück zum Zitat Amoils SP, Deist MB, Gous P, Amoils PM (2000) Iatrogenic keratectasia after laser in situ keratomileusis for less than −4.0 to −7.0 diopters of myopia. J Cataract Refract Surg 26:967–977PubMedCrossRef Amoils SP, Deist MB, Gous P, Amoils PM (2000) Iatrogenic keratectasia after laser in situ keratomileusis for less than −4.0 to −7.0 diopters of myopia. J Cataract Refract Surg 26:967–977PubMedCrossRef
10.
Zurück zum Zitat Fogla R, Padmanabhan P (2004) Bilateral keratectasia after unilateral laser in situ keratomileusis. J Cataract Refract Surg 30:2033–2034PubMedCrossRef Fogla R, Padmanabhan P (2004) Bilateral keratectasia after unilateral laser in situ keratomileusis. J Cataract Refract Surg 30:2033–2034PubMedCrossRef
11.
Zurück zum Zitat Ambrosio R Jr, Dawson DG, Salomao M, Guerra FP, Caiado AL, Belin MW (2010) Corneal ectasia after LASIK despite low preoperative risk: tomographic and biomechanical findings in the unoperated, stable, fellow eye. J Refract Surg 26:906–911PubMedCrossRef Ambrosio R Jr, Dawson DG, Salomao M, Guerra FP, Caiado AL, Belin MW (2010) Corneal ectasia after LASIK despite low preoperative risk: tomographic and biomechanical findings in the unoperated, stable, fellow eye. J Refract Surg 26:906–911PubMedCrossRef
12.
Zurück zum Zitat Hjortdal JO, Vestergaard AH, Ivarsen A, Ragunathan S, Asp S (2012) Predictors for the outcome of small-incision lenticule extraction for myopia. J Refract Surg 28:865–871PubMedCrossRef Hjortdal JO, Vestergaard AH, Ivarsen A, Ragunathan S, Asp S (2012) Predictors for the outcome of small-incision lenticule extraction for myopia. J Refract Surg 28:865–871PubMedCrossRef
13.
Zurück zum Zitat Abahussin M, Hayes S, Knox Cartwright NE et al (2009) 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Invest Ophthalmol Vis Sci 50:5159–5164PubMedCrossRef Abahussin M, Hayes S, Knox Cartwright NE et al (2009) 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Invest Ophthalmol Vis Sci 50:5159–5164PubMedCrossRef
14.
Zurück zum Zitat Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31:156–162PubMedCrossRef Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31:156–162PubMedCrossRef
15.
Zurück zum Zitat Ambrosio R Jr, Nogueira LP, Caldas DL et al (2011) Evaluation of corneal shape and biomechanics before LASIK. Int Ophthalmol Clin 51:11–38PubMedCrossRef Ambrosio R Jr, Nogueira LP, Caldas DL et al (2011) Evaluation of corneal shape and biomechanics before LASIK. Int Ophthalmol Clin 51:11–38PubMedCrossRef
16.
Zurück zum Zitat Glass DH, Roberts CJ, Litsky AS, Weber PA (2008) A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. Invest Ophthalmol Vis Sci 49:3919–3926PubMedCrossRef Glass DH, Roberts CJ, Litsky AS, Weber PA (2008) A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. Invest Ophthalmol Vis Sci 49:3919–3926PubMedCrossRef
17.
Zurück zum Zitat Vestergaard A, Ivarsen A, Asp S, Hjortdal JO (2012) Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx(®) flex and comparison with a retrospective study of FS-laser in situ keratomileusis. Acta Ophthalmol 91:355–362PubMedCrossRef Vestergaard A, Ivarsen A, Asp S, Hjortdal JO (2012) Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx(®) flex and comparison with a retrospective study of FS-laser in situ keratomileusis. Acta Ophthalmol 91:355–362PubMedCrossRef
18.
Zurück zum Zitat Lam AK, Chen D, Tse J (2010) The usefulness of waveform score from the ocular response analyzer. Optom Vis Sci 87:195–199PubMedCrossRef Lam AK, Chen D, Tse J (2010) The usefulness of waveform score from the ocular response analyzer. Optom Vis Sci 87:195–199PubMedCrossRef
19.
Zurück zum Zitat Reinstein DZ, Srivannaboon S, Archer TJ, Silverman RH, Sutton H, Coleman DJ (2006) Probability model of the inaccuracy of residual stromal thickness prediction to reduce the risk of ectasia after LASIK part II: quantifying population risk. J Refract Surg 22:861–870PubMedCrossRef Reinstein DZ, Srivannaboon S, Archer TJ, Silverman RH, Sutton H, Coleman DJ (2006) Probability model of the inaccuracy of residual stromal thickness prediction to reduce the risk of ectasia after LASIK part II: quantifying population risk. J Refract Surg 22:861–870PubMedCrossRef
20.
Zurück zum Zitat Leccisotti A (2007) Corneal ectasia after photorefractive keratectomy. Graefes Arch Clin Exp Ophthalmol 245:869–875PubMedCrossRef Leccisotti A (2007) Corneal ectasia after photorefractive keratectomy. Graefes Arch Clin Exp Ophthalmol 245:869–875PubMedCrossRef
21.
Zurück zum Zitat Reinstein DZ, Archer TJ, Randleman JB (2013) Mathematical model to compare the relative tensile strength of the cornea after PRK, LASIK, and small incision lenticule extraction. J Refract Surg 29:454–460PubMedCrossRef Reinstein DZ, Archer TJ, Randleman JB (2013) Mathematical model to compare the relative tensile strength of the cornea after PRK, LASIK, and small incision lenticule extraction. J Refract Surg 29:454–460PubMedCrossRef
22.
Zurück zum Zitat Kirwan C, O'Keefe M (2008) Corneal hysteresis using the reichert ocular response analyser: findings pre- and post-LASIK and LASEK. Acta Ophthalmol 86:215–218PubMedCrossRef Kirwan C, O'Keefe M (2008) Corneal hysteresis using the reichert ocular response analyser: findings pre- and post-LASIK and LASEK. Acta Ophthalmol 86:215–218PubMedCrossRef
23.
Zurück zum Zitat Hamilton DR, Johnson RD, Lee N, Bourla N (2008) Differences in the corneal biomechanical effects of surface ablation compared with laser in situ keratomileusis using a microkeratome or femtosecond laser. J Cataract Refract Surg 34:2049–2056PubMedCrossRef Hamilton DR, Johnson RD, Lee N, Bourla N (2008) Differences in the corneal biomechanical effects of surface ablation compared with laser in situ keratomileusis using a microkeratome or femtosecond laser. J Cataract Refract Surg 34:2049–2056PubMedCrossRef
24.
Zurück zum Zitat Uzbek AK, Kamburoglu G, Mahmoud AM, Roberts CJ (2011) Change in biomechanical parameters after flap creation using the intralase femtosecond laser and subsequent excimer laser ablation. Curr Eye Res 36:614–619PubMedCrossRef Uzbek AK, Kamburoglu G, Mahmoud AM, Roberts CJ (2011) Change in biomechanical parameters after flap creation using the intralase femtosecond laser and subsequent excimer laser ablation. Curr Eye Res 36:614–619PubMedCrossRef
25.
Zurück zum Zitat Agca A, Ozgurhan EB, Demirok A, et al. Comparison of corneal hysteresis and corneal resistance factor after small incision lenticule extraction and femtosecond laser-assisted LASIK: a prospective fellow eye study. Cont Lens Anterior Eye. 2013. Agca A, Ozgurhan EB, Demirok A, et al. Comparison of corneal hysteresis and corneal resistance factor after small incision lenticule extraction and femtosecond laser-assisted LASIK: a prospective fellow eye study. Cont Lens Anterior Eye. 2013.
26.
Zurück zum Zitat Huseynova T, Waring GO, Roberts C, Krueger RR, Tomita M. Corneal biomechanics as a function of intraocular pressure and pachymetry by dynamic infrared signal and scheimpflug imaging analysis in normal eyes. Am J Ophthalmol. 2014. Huseynova T, Waring GO, Roberts C, Krueger RR, Tomita M. Corneal biomechanics as a function of intraocular pressure and pachymetry by dynamic infrared signal and scheimpflug imaging analysis in normal eyes. Am J Ophthalmol. 2014.
27.
Zurück zum Zitat Pepose JS, Feigenbaum SK, Qazi MA, Sanderson JP, Roberts CJ (2007) Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry. Am J Ophthalmol 143:39–47PubMedCrossRef Pepose JS, Feigenbaum SK, Qazi MA, Sanderson JP, Roberts CJ (2007) Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry. Am J Ophthalmol 143:39–47PubMedCrossRef
28.
Zurück zum Zitat Nemeth G, Hassan Z, Csutak A, Szalai E, Berta A, Modis L (2013) Repeatability of ocular biomechanical data measurements with a scheimpflug-based noncontact device on normal corneas. J Refract Surg 29(8):558–563PubMed Nemeth G, Hassan Z, Csutak A, Szalai E, Berta A, Modis L (2013) Repeatability of ocular biomechanical data measurements with a scheimpflug-based noncontact device on normal corneas. J Refract Surg 29(8):558–563PubMed
29.
Zurück zum Zitat Daxer A, Misof K, Grabner B, Ettl A, Fratzl P (1998) Collagen fibrils in the human corneal stroma: structure and aging. Invest Ophthalmol Vis Sci 39:644–648PubMed Daxer A, Misof K, Grabner B, Ettl A, Fratzl P (1998) Collagen fibrils in the human corneal stroma: structure and aging. Invest Ophthalmol Vis Sci 39:644–648PubMed
30.
Zurück zum Zitat Ang M, Chaurasia SS, Angunawela RI et al (2012) Femtosecond lenticule extraction (FLEx): clinical results, interface evaluation, and intraocular pressure variation. Invest Ophthalmol Vis Sci 53:1414–1421PubMedCrossRef Ang M, Chaurasia SS, Angunawela RI et al (2012) Femtosecond lenticule extraction (FLEx): clinical results, interface evaluation, and intraocular pressure variation. Invest Ophthalmol Vis Sci 53:1414–1421PubMedCrossRef
31.
Zurück zum Zitat Landoulsi H, Saad A, Haddad NN, Guilbert E, Gatinel D (2013) Repeatability of ocular response analyzer waveform parameters in normal eyes and eyes after refractive surgery. J Refract Surg 29(10):709–714PubMed Landoulsi H, Saad A, Haddad NN, Guilbert E, Gatinel D (2013) Repeatability of ocular response analyzer waveform parameters in normal eyes and eyes after refractive surgery. J Refract Surg 29(10):709–714PubMed
32.
Zurück zum Zitat Vestergaard A, Grauslund J, Ivarsen A, Hjortdal J (2013) Central corneal sublayer pachymetry and biomechanical properties after refrative femtosecond laser lenicule extraction. J Refract Surg 30(2):102–108CrossRef Vestergaard A, Grauslund J, Ivarsen A, Hjortdal J (2013) Central corneal sublayer pachymetry and biomechanical properties after refrative femtosecond laser lenicule extraction. J Refract Surg 30(2):102–108CrossRef
Metadaten
Titel
Corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx smile by Scheimpflug-based dynamic tonometry
verfasst von
Iben Bach Pedersen
Sashia Bak-Nielsen
Anders Højslet Vestergaard
Anders Ivarsen
Jesper Hjortdal
Publikationsdatum
01.08.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 8/2014
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2667-6

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