Correction to: CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17
verfasst von:
Kai Han, Feng-Wei Wang, Chen-Hui Cao, Han Ling, Jie-Wei Chen, Ri-Xin Chen, Zi-Hao Feng, Jie Luo, Xiao-Han Jin, Jin-Ling Duan, Shu-Man Li, Ning-Fang Ma, Jing-Ping Yun, Xin-Yuan Guan, Zhi-Zhong Pan, Ping Lan, Rui-Hua Xu, Dan Xie
Following publication of the original article [1], the authors identified some minor errors in image-typesetting in Fig. 4; specifically, the transwell invasion assay of HCT116 cells with circLONP2-overexpression shown in Fig. 4b.
Fig. 4
circLONP2 is essential for CRC metastasis. a, b Overexpression of circLONP2 significantly enhanced the migration and invasion ability of CRC cells. c, d Knockdown of circLONP2 by ASO significantly suppressed the migration and invasion ability of CRC cells. e, f In vivo tail vein injection model confirmed that overexpression or knockdown of circLONP2 could significantly promote or attenuate CRC cells metastasize to lung, respectively. All detection of circLONP2 by RT-qPCR was normalized to GAPDH. All experiments were repeated for three times, data were shown as mean±SD, * P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001 in Mann-Whitney U test (a, c, e, f), or independent Student’s t test (b, d)
×
The corrected figure is given below. The corrections do not have any effect on the final conclusions of the paper.
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Correction to: CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17
verfasst von
Kai Han Feng-Wei Wang Chen-Hui Cao Han Ling Jie-Wei Chen Ri-Xin Chen Zi-Hao Feng Jie Luo Xiao-Han Jin Jin-Ling Duan Shu-Man Li Ning-Fang Ma Jing-Ping Yun Xin-Yuan Guan Zhi-Zhong Pan Ping Lan Rui-Hua Xu Dan Xie
Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.
Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.
Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.
„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.
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