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Erschienen in:
20.06.2020 | Correction
Correction to: Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos
Erschienen in: Medical Microbiology and Immunology | Ausgabe 5/2020
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In the original article, the legends for the Figs. 1 and 2 published incorrectly. Please find the correct legends for the both Figs. 1 and 2 as below.
Fig. 1
The engagement of tetraspanins during the sperm and egg interaction. 1. Recognition and primary binding of capacitated sperm to the cumulus cells (CC) and zona pellucida (ZP) of the egg is assisted by CD9, CD81 and CD63 and followed by 2. the sperm acrosome reaction and CD9 and CD81 relocation (mouse) that facilitates 3. a secondary sperm binding in presence of CD9, CD81 (mouse, human) and CD151 (mouse, human, cattle). This result in 4. the sperm penetration through ZP and 5. adhesion to the oocyte plasma membrane (PM) both in assistance of CD9, CD81 and CD151. Finally, 6. in presence of CD9, CD81 and CD151 gamete membrane fusion occurs followed by pronuclei fusion and a zygote formation. 7. shortly after a sperm fuses with the oocyte, the impermeability of ZP to other sperm is ensured by the polyspermy block. PB polar body, PVS perivitelline space
Fig. 2
Localization of tetraspanins in mouse, bull and human spermatozoa. The diagram presents the localization of CD9 (green), CD81 (red) and CD151 (blue) in mouse, bull and human spermatozoa before and after the acrosome reaction. Plasma membrane (PM), outer acrosomal membrane (OAM), inner acrosomal membrane (IAM) and equatorial region (ER)
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