Data used in the preparation of this article were obtained from Parkinson’s Progression Markers Initiative database (
www.ppmi-info.org/data). The study population consisted of healthy controls with screening
123I-FP-CIT single photon emission tomography (SPECT). University of Pennsylvania Smell Identification Test (UPSIT) was assessed to evaluate the olfactory function. Results: Totally, 181 healthy subjects (117 male, 64 female) with
123I-FP-CIT SPECT data were included in this study. Specific binding ratios (SBRs) of the caudate nucleus (rho = -0.4217,
p < 0.0001), putamen (rho = -0.2292,
p = 0.0019), and striatum (rho=-0.3425,
p < 0.0001) showed a reduction with ageing. SBRs of the caudate nucleus, putamen, and striatum were positively correlated with UPSIT (rho = 0.3716,
p < 0.0001; rho = 0.3655,
p < 0.0001; rho = 0.3880,
p < 0.0001). After controlling for age by partial correlation, SBRs of the caudate nucleus, putamen, and striatum showed an influence on UPSIT (rho = 0.3288,
p < 0.0001; rho = 0.3374,
p < 0.0001; rho = 0.3511,
p < 0.0001).