nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.04.2019 | Rhinology

Correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery

verfasst von: Lichuan Zhang, Chunhua Hu, Zhifu Sun, Pengfei Han, Xingyu Han, Haili Sun, Dawei Wu, Qianwen Lv, Xiaoguang Yan, Wei Yu, Thomas Hummel, Yongxiang Wei

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To investigate the correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS).

Methods

This was a cross-sectional study including 40 patients with a history of ESS for CRSwNP recruited consecutively. Visual analog scale score and the Lund–Kennedy endoscopic score were recorded. Biopsies of the ethmoidal sinus mucosal were performed and evaluated. Chemosensory functions were measured by Sniffin’ Sticks and chemosensory event-related potentials (CSERP). The associations between chemosensory functions and tissue eosinophil count were analyzed using Spearman correlation and partial correlation after adjusting the confounding factors. Kendall’s tau-b correlation was performed between sneezing score and CSERP with ethyl alcohol (EAL) stimulation.

Results

Olfactory and trigeminal nerve function was successfully evaluated using CSERP. Postoperative tissue eosinophil count was correlated with threshold (T) score (partial correlation coefficient r = − 0.460, p = 0.012) and CSERP peak latency for olfactory (N1: partial r = 0.471, p = 0.010; P2: partial r = 0.487, p = 0.007) and mixed olfactory–trigeminal (N1: partial r = − 0.516, p = 0.008; P2: partial r = − 0.590, p = 0.002). There were also correlations between T score and N1 latency with phenyl ethyl alcohol (PEA) (partial r = − 0.560, p < 0.001), between sneezing score and N1 latency with EAL (Kendall’s tau-b = − 0.40, p = 0.005).

Conclusions

Postoperative tissue eosinophilia is significantly associated with postoperative olfactory disorders as assessed by Sniffin’ Sticks and CSERP peak latency. Furthermore, olfaction as measured by T score correlates with olfactory ERP latency in inflammation-associated olfactory dysfunction. Trigeminal sensitivity also appears to relate to tissue eosinophilia, indicating mucosal inflammation can affect both sensory systems in the nose.

Cao PP, Li HB, Wang BF, Wang SB, You XJ et al (2009) Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol 124:478–484. https://doi.org/10.1016/j.jaci.2009.05.017 CrossRefPubMed

Tomassen P, Vandeplas G, Van Zele T et al (2016) Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immunol 137:1449–1456. https://doi.org/10.1016/j.jaci.2015.12.1324 CrossRefPubMed

Chung JH, Lee YJ, Kang TW, Kim KR, Jang DP, Kim IY, Cho SH (2015) Altered quality of life and psychological health (SCL-90-R) in patients with chronic rhinosinusitis with nasal polyps polyps. Ann Otol Rhinol Laryngol 124:663–670. https://doi.org/10.1177/0003489415576181 CrossRefPubMed

Ishitoya J, Sakuma Y, Tsukuda M (2010) Eosinophilic chronic rhinosinusitis in Japan. Allergol Int 59:239–245. https://doi.org/10.2332/allergolint.10-RAI-0231 CrossRefPubMed

Wu D, Bleier BS, Li L, Zhan X, Zhang L, Lv Q, Wang J, Wei Y (2018) Clinical phenotypes of nasal polyps and comorbid asthma based on cluster analysis of disease history. J Allergy Clin Immunol Pract 6:1297–1305. https://doi.org/10.1016/j.jaip.2017.09.020 CrossRefPubMed

Wu D, Bleier BS, Wei Y (2018) Temporary olfactory improvement in chronic rhinosinusitis with nasal polyps after treatment. Eur Arch Otorhinolaryngol 275:2193–2202. https://doi.org/10.1007/s00405-018-5066-5 CrossRefPubMed

Oka H, Tsuzuki K, Takebayashi H, Kojima Y, Daimon T, Sakagami M (2013) Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis. Auris Nasus Larynx 40:452–457. https://doi.org/10.1016/j.anl.2012.12.001 CrossRefPubMed

Haxel BR, Bertz-Duffy S, Fruth K, Letzel S, Mann WJ, Muttray A (2012) Comparison of subjective olfaction ratings in patients with and without olfactory disorders. J Laryngol Otol 126:692–697. https://doi.org/10.1017/S002221511200076X CrossRefPubMed

Hummel T (2000) Assessment of intranasal trigeminal function. Int J Psychophysiol 36:147–155CrossRefPubMed

10.

Doerfler H, Hummel T, Klimek L, Kobal G (2006) Intranasal trigeminal sensitivity in subjects with allergic rhinitis. Eur Arch Otorhinolaryngol 263:86–90CrossRefPubMed

11.

Seidman MD, Gurgel RK, Lin SY et al (2015) Clinical practice guideline: allergic rhinitis. Otolaryngol Head Neck Surg 152:S1–S43. https://doi.org/10.1177/0194599814562166 CrossRefPubMed

12.

Bateman ED, Hurd SS, Barnes PJ et al (2008) Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 31:143–178. https://doi.org/10.1183/09031936.00138707 CrossRefPubMed

13.

Liu Z, Lu X, Zhang XH, Bochner BS, Long XB, Zhang F, Wang H, Cui YH (2009) Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa. Allergy 64:149–157. https://doi.org/10.1111/j.1398-9995.2008.01847.x CrossRefPubMed

14.

Lund VJ, Kennedy DW (1995) Quantification for staging sinusitis. The staging and therapy group. Ann Otol Rhinol Laryngol Suppl 167:17–21CrossRefPubMed

15.

Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52CrossRefPubMed

16.

Kobal G, Klimek L, Wolfensberger M et al (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, olfactory thresholds. Eur Arch Otorhinolaryngol 257:205–211CrossRefPubMed

17.

Kobal G, Hummel T (1998) Olfactory and intranasal trigeminal event-related potentials in anosmic patients. Laryngoscope 108:1033–1035CrossRefPubMed

18.

Rombaux P, Mouraux A, Bertrand B, Guerit JM, Hummel T (2006) Assessment of olfactory and trigeminal function using chemosensory event-related potentials. Neurophysiol Clin 36:53–62CrossRefPubMed

19.

Olofsson JK, Nordin S (2004) Gender differences in chemosensory perception and event-related potentials. Chem Senses 29:629–637CrossRefPubMed

20.

Beswick DM, Mace JC, Chowdhury NI, Alt JA, Hwang PH, DeConde AS, Smith TL (2017) Comparison of surgical outcomes between patients with unilateral and bilateral chronic rhinosinusitis. Int Forum Allergy Rhinol 7:1162–1169. https://doi.org/10.1002/alr.22020 CrossRefPubMedPubMedCentral

21.

Knížek Z, Vodička J, Brothánková P, Shejbalová H (2017) Olfactory function in patients undergoing FESS for chronic rhinosinusitis. Cas Lek Cesk 156:187–191PubMed

22.

Prasad S, Fong E, Ooi EH (2017) Systematic review of patient-reported outcomes after revision endoscopic sinus surgery. Am J Rhinol Allergy 31:248–255. https://doi.org/10.2500/ajra.2017.31.4446 CrossRefPubMed

23.

Pause BM, Krauel K (2000) Chemosensory event-related potentials (CSERP) as a key to the psychology of odors. Int J Psychophysiol 36:105–122CrossRefPubMed

24.

Wu J, Chandra RK, Li P, Hull BP, Turner JH (2018) Olfactory and middle meatal cytokine levels correlate with olfactory function in chronic rhinosinusitis. Laryngoscope 128:E304–E310. https://doi.org/10.1002/lary.27112 CrossRefPubMed

25.

Bachert C, Sousa AR, Lund VJ, Scadding GK, Gevaert P (2017) Reduced need for surgery in severe nasal polyposis with mepolizumab: randomised trial. J Allergy Clin Immunol 140:1024–1031. https://doi.org/10.1016/j.jaci.2017.05.044 CrossRefPubMed

26.

Pause BM, Sojka B, Ferstl R (1997) Central processing of odor concentration is a temporal phenomenon as revealed by chemosensory event-related potentials (CSERP). Chem Senses 22:9–26CrossRefPubMed

27.

Kohli P, Naik AN, Farhood Z, Ong AA, Nguyen SA, Soler ZM, Schlosser RJ (2016) Olfactory outcomes after endoscopic sinus surgery for chronic rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg 155:936–948CrossRefPubMed

28.

Banglawala SM, Oyer SL, Lohia S, Psaltis AJ, Soler ZM, Schlosser RJ (2014) Olfactory outcomes in chronic rhinosinusitis with nasal polyposis after medical treatments: a systematic review and meta-analysis. Int Forum Allergy Rhinol 4:986–994. https://doi.org/10.1002/alr.21373 CrossRefPubMed

29.

Levy JM, Mace JC, Sansoni ER, Soler ZM, Smith TL (2016) Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis. Int Forum Allergy Rhinol 6:1188–1195. https://doi.org/10.1002/alr.21800 CrossRefPubMedPubMedCentral

30.

Poetker DM, Jakubowski LA, Lai D, Hwang PH, Wright ED, Smith TL (2013) Oral corticosteroids in the management of adult chronic rhinosinusitis with and without nasal polyps: an evidence-based review with recommendations. Int Forum Allergy Rhinol 3:104–120. https://doi.org/10.1002/alr.21072 CrossRefPubMed

31.

Daiber P, Genovese F, Schriever VA, Hummel T, Möhrlen F, Frings S (2013) Neuropeptide receptors provide a signalling pathway for trigeminal modulation of olfactorytransduction. Eur J Neurosci 37:572–582. https://doi.org/10.1111/ejn.12066 CrossRefPubMed

32.

Kobal G, Hummel C (1988) Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa. Electroencephalogr Clin Neurophysiol 71:241–250CrossRefPubMed

33.

Livermore A, Hummel T (2004) The influence of training on chemosensory event-related potentials and interactions between the olfactory and trigeminal systems. Chem Senses 29:41–51CrossRefPubMed

34.

Yu S, Ouyang A (2011) Effect of synthetic cationic protein on mechanoexcitability of vagal afferent nerve subtypes in guinea pigesophagus. Am J Physiol Gastrointest Liver Physiol 301:G1052–G1058. https://doi.org/10.1152/ajpgi.00015.2011 CrossRefPubMedPubMedCentral

35.

Drake MG, Scott GD, Blum ED, Lebold KM, Nie Z, Lee JJ, Fryer AD, Costello RW, Jacoby DB (2018) Eosinophils increase airway sensory nerve density in mice and in human asthma. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aar8477 CrossRefPubMedPubMedCentral

36.

Durack DT, Ackerman SJ, Loegering DA, Gleich GJ (1981) Purification of human eosinophil-derived neurotoxin. Proc Natl Acad Sci USA 78:5165–5169CrossRefPubMed

37.

Fredens K, Dahl R, Venge P (1982) The Gordon phenomenon induced by the eosinophil cationic protein and eosinophil protein X. J Allergy Clin Immunol 70:361–366CrossRefPubMed

Titel: Correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery
verfasst von: Lichuan Zhang
Chunhua Hu
Zhifu Sun
Pengfei Han
Xingyu Han
Haili Sun
Dawei Wu
Qianwen Lv
Xiaoguang Yan
Wei Yu
Thomas Hummel
Yongxiang Wei
Publikationsdatum: 01.04.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2019
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05413-9

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery