Skip to main content

13.01.2022 | COVID-19 | Chest Zur Zeit gratis

Lung vessel volume evaluated with CALIPER software is an independent predictor of mortality in COVID-19 patients: a multicentric retrospective analysis

European Radiology
Chiara Romei, Zeno Falaschi, Pietro S. C. Danna, Chiara Airoldi, Michele Tonerini, Erika Rocchi, Salvatore C. Fanni, Claudio D’Amelio, Greta Barbieri, Giusy Tiseo, Roberto Arioli, Alessio Paschè, Ronald A. Karwoski, Annalisa De Liperi, Brian J. Bartholmai, Alessandro Carriero
Wichtige Hinweise
Chiara Romei and Zeno Falaschi contributed equally to this work.
The institution from which the work originated is the 2nd Radiology Unit, Pisa University-Hospital, Via Paradisa 2, Pisa, 56,124, Italy

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.



Computer-Aided Lung Informatics for Pathology Evaluation and Ratings (CALIPER) software has already been widely used in the evaluation of interstitial lung diseases (ILD) but has not yet been tested in patients affected by COVID-19. Our aim was to use it to describe the relationship between Coronavirus Disease 2019 (COVID-19) outcome and the CALIPER-detected pulmonary vascular-related structures (VRS).

Materials and methods

We performed a multicentric retrospective study enrolling 570 COVID-19 patients who performed a chest CT in emergency settings in two different institutions. Fifty-three age- and sex-matched healthy controls were also identified. Chest CTs were analyzed with CALIPER identifying the percentage of VRS over the total lung parenchyma. Patients were followed for up to 72 days recording mortality and required intensity of care.


There was a statistically significant difference in VRS between COVID-19-positive patients and controls (median (iqr) 4.05 (3.74) and 1.57 (0.40) respectively, p = 0.0001). VRS showed an increasing trend with the severity of care, p < 0.0001. The univariate Cox regression model showed that VRS increase is a risk factor for mortality (HR 1.17, p < 0.0001). The multivariate analysis demonstrated that VRS is an independent explanatory factor of mortality along with age (HR 1.13, p < 0.0001).


Our study suggests that VRS increases with the required intensity of care, and it is an independent explanatory factor for mortality.

Key Points

The percentage of vascular-related structure volume (VRS) in the lung is significatively increased in COVID-19 patients.
VRS showed an increasing trend with the required intensity of care, test for trend p< 0.0001.
Univariate and multivariate Cox models showed that VRS is a significant and independent explanatory factor of mortality.

Nutzen Sie Ihre Chance: Dieser Inhalt ist zurzeit gratis verfügbar.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Unsere Produktempfehlungen

e.Med Interdisziplinär


Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner*in

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Jetzt e.Med zum Sonderpreis bestellen!

e.Med Radiologie


Mit e.Med Radiologie erhalten Sie Zugang zu CME-Fortbildungen des Fachgebietes Radiologie, den Premium-Inhalten der radiologischen Fachzeitschriften, inklusive einer gedruckten Radiologie-Zeitschrift Ihrer Wahl.

Über diesen Artikel

Coronavirus Corona-Update

Die aktuelle Entwicklung im Überblick: Nachrichten, Webinare, Übersichtsarbeiten.