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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 1/2023

29.04.2022 | COVID-19 | Original Article

Outcomes and risk factors for death among hospitalized children and adolescents with kidney diseases and COVID-19: an analysis of a nationwide database

verfasst von: Mariana A. Vasconcelos, Ana Carmen Q. Mendonça, Enrico A. Colosimo, Noureddin Nourbakhsh, Hercílio Martelli-Júnior, Ludmila R. Silva, Maria Christina L. Oliveira, Clara C. Pinhati, Robert H. Mak, Ana Cristina Simões e Silva, Eduardo A. Oliveira

Erschienen in: Pediatric Nephrology | Ausgabe 1/2023

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Abstract

Background

Patients with kidney diseases (KD) appear to be at particularly high risk for severe COVID-19. This study aimed to characterize the clinical outcomes and risk factors for COVID-19-related death in a large cohort of hospitalized pediatric patients with KD.

Methods

We performed an analysis of all pediatric patients with KD and COVID-19 registered in SIVEP-Gripe, a Brazilian nationwide surveillance database, between February 16, 2020, and May 29, 2021. The primary outcome was time to death, which was evaluated considering discharge as a competitive risk by using cumulative incidence function.

Results

Among 21,591 hospitalized patients with COVID-19, 290 cases (1.3%) had KD. Of these, 59 (20.8%) had a fatal outcome compared with 7.5% of the non-KD cohort (P < 0.001). Pediatric patients with KD had an increased hazard of death compared with the non-KD cohort (Hazard ratio [HR] = 2.85, 95% CI 2.21–3.68, P < 0.0001). After adjustment, the factors associated with the death among KD patients were living in Northeast (HR 2.16, 95% CI 1.13–4.31) or North regions (HR 3.50, 95% CI 1.57–7.80), oxygen saturation < 95% at presentation (HR 2.31, 95% CI 1.30–4.10), and presence of two or more associated comorbidities (HR 2.10, 95% CI 1.08–4.04).

Conclusions

Children and adolescents with KD had a higher risk of death compared with the non-KD cohort. The higher risk was associated with low oxygen saturation at admission, living in socioeconomically disadvantaged regions, and presence of other pre-existing comorbidities.

Graphical abstract

A higher resolution version of the Graphical abstract is available as Supplementary information
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Metadaten
Titel
Outcomes and risk factors for death among hospitalized children and adolescents with kidney diseases and COVID-19: an analysis of a nationwide database
verfasst von
Mariana A. Vasconcelos
Ana Carmen Q. Mendonça
Enrico A. Colosimo
Noureddin Nourbakhsh
Hercílio Martelli-Júnior
Ludmila R. Silva
Maria Christina L. Oliveira
Clara C. Pinhati
Robert H. Mak
Ana Cristina Simões e Silva
Eduardo A. Oliveira
Publikationsdatum
29.04.2022
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
Pediatric Nephrology / Ausgabe 1/2023
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-022-05588-0

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