Erschienen in:
22.01.2021 | COVID-19 | Original Article
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Prevalence of Clostridioides difficile and Other Gastrointestinal Pathogens in Patients with COVID-19
verfasst von:
Monika Laszkowska, Judith Kim, Adam S. Faye, Andrew M. Joelson, Myles Ingram, Han Truong, Elisabeth R. Silver, Benjamin May, William G. Greendyke, Jason Zucker, Benjamin Lebwohl, Chin Hur, Daniel E. Freedberg
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 12/2021
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Abstract
Background
Gastrointestinal symptoms are common in patients with COVID-19, but prevalence of co-infection with enteric pathogens is unknown.
Aims
This study assessed the prevalence of enteric infections among hospitalized patients with COVID-19.
Methods
We evaluated 4973 hospitalized patients ≥ 18 years of age tested for COVID-19 from March 11 through April 28, 2020, at two academic hospitals. The primary exposure was a positive COVID-19 test. The primary outcome was detection of a gastrointestinal pathogen by PCR stool testing.
Results
Among 4973 hospitalized individuals, 311 were tested for gastrointestinal infections (204 COVID-19 positive, 107 COVID-19 negative). Patients with COVID-19 were less likely to test positive compared to patients without COVID-19 (10% vs 22%, p < 0.01). This trend was driven by lower rates of non-C.difficile infections (11% vs 22% in COVID-19 positive vs. negative, respectively, p = 0.04), but not C. difficile infection (5.1% vs. 8.2%, p = 0.33). On multivariable analysis, infection with COVID-19 remained significantly associated with lower odds of concurrent GI infection (aOR 0.49, 95% CI 0.24–0.97), again driven by reduced non-C.difficile infection. Testing for both C.difficile and non-C.difficile enteric infection decreased dramatically during the pandemic.
Conclusions
Pathogens aside from C.difficile do not appear to be a significant contributor to diarrhea in COVID-19 positive patients.