Introduction
The ongoing stress of the COVID-19 pandemic has placed healthcare workers (HCWs) at risk for anxiety, depression, and posttraumatic stress disorders (PTSD) [
1]. Healthcare workers already confronted high risks for the negative effects of chronic stress before the pandemic - stress now aggravated by fear, frustration, demoralization, and multiple other challenges [
2,
3]. Constantly expected to respond to medical emergencies, HCWs often experience distress about contracting and spreading the disease, with some facing repeated exposure to terminally ill patients who are cut off from family and friends [
4]. In addition, they are concerned about staff shortages and competency when redeployed without proper training [
4]. Healthcare workers may feel conflicted, caught between their wish to fulfill their duty and their own need to survive the pandemic. In the context of such pressures, studies have shown high psychopathology among HCWs, with recent reviews finding 21–29% self-reported anxiety, 21–26% depression, and 20–29% PTSD [
5‐
9]. Published studies have assessed symptoms cross-sectionally, usually in the early phases of the pandemic or in countries that more quickly contained the spread of the virus (e.g., China). A literature search found no longitudinal studies evaluating mental health trajectories among HCWs during the COVID-19 era. The current study longitudinally assessed the three-month burden of the ongoing COVID-19 pandemic on HCWs in the chronically hard-hit United States (September – December 2020).
At the height of the pandemic, many HCWs had to make crucial life and death decisions about acutely ill COVID-19 patients. These include rationing of care, employing ventilators, and prioritizing who is treated for disease [
10]. Consequently, COVID-19 exposed HCWs to experiences that could violate their moral values, potentially causing “moral injury” [
11], which is defined as “the lasting stress of perpetrating, failing to prevent, or witnessing acts that transgress or deeply violate one’s moral or ethical code” [
12]. An emerging clinical and conceptual literature in veterans and civilians describes moral injury and its detrimental impact on mental health [
13]. Moral injuries generate anger, shame, guilt, and mistrust, and have demonstrated associations to functional deficits and psychopathology including PTSD, depression, suicidal ideation, and drug and alcohol abuse [
9,
14‐
16]. Moral injury may be a major concern for HCWs who witness the devastating impact of COVID-19 illness while often feeling helpless to respond adequately. Lack of resources, guidance, and training amplify feelings of incompetence and betrayal by leaders. Although moral injury is not a mental illness per se, it may contribute to the development of mental health problems. To date, however, the general prevalence of moral injury is unknown, and no study has examined moral injury and its association with clinical symptoms among HCWs.
The aftermath of the COVID-19 pandemic holds even graver ramifications for HCWs. While HCWs already face higher suicide risk, rates may further increase during and following the COVID-19 pandemic for several reasons, including concerns of infection, fear of illness, social isolation, traumatic experiences, and increased anxiety and depression [
17‐
19]. Work stress, shortages of staff and necessary personal protective equipment, and overwhelmed facilities are additional pressures. Research found loneliness and reduced access to community support and mental health treatment were associated with suicidal ideation and behaviors [
20]. To date, no studies have examined the relationship between COVID-19 and suicidal ideation over time.
In sum, previous studies of the effects of COVID-19 on HCWs were cross-sectional, conducted relatively early in the pandemic, and used a narrow range of measures. We designed this study to longitudinally assess clinical symptoms including suicidal ideation, moral injury, and examine the associations between them. Assessments were conducted at baseline and 30 and 90 days thereafter. We hypothesized that between September and December 2020: 1) HCWs would exhibit high levels of self-reported anxiety, depression, PTSD, and moral injury at baseline and throughout the follow-ups, and 2) clinical symptoms reported by the HCWs would be strongly associated with moral injury.
Discussion
Our study assessed healthcare workers’ self-reported levels of anxiety, depression, suicidal ideation, PTSD, and moral injury over 90 days between September and December 2020. Analysis tested associations between clinical symptoms, moral injury, and COVID-19 exposure. As hypothesized, we found high levels of symptomatology and moral injury, both of which remained high across timepoints. Psychopathology and moral injury were correlated across all timepoints. This is the first study to demonstrate such associations and longitudinal trajectory of the mental health consequences of the COVID-19 pandemic among HCWs.
Around half of our participants reported perceived transgression by others (e.g., “I saw things that were morally wrong”) and perceived betrayal (“I feel betrayed by leaders whom I once trusted”). MIES scores were associated with the severity of clinical symptoms, including suicidal ideation, suggesting that HCWs face greater vulnerability in the COVID-19 era. These findings concord with previous studies demonstrating a correlation between moral injury and psychopathology among military veterans [
13,
15,
16,
33‐
35]. Furthermore, a recent review examining traumatic responses among HCWs during the COVID-19 pandemic has highlighted the presence of trauma-related stress [
36]. Our findings suggest that COVID-19 pandemic effects on HCWs resemble the lingering effects following a traumatic event. However, previous publications describing moral injury among HCWs during this pandemic have been purely commentary or theoretical, without adequately assessing moral injury levels or their implications [
37‐
40]. This study is the first to assess moral injury levels and their relationships with a range of psychopathology among HCWs, providing an initial empirical basis for the strong relations between this phenotype and moral injury in HCWs.
We found disturbingly high levels of self-reported psychopathology. A relatively stable range of 52–62% of the surveyed HCWs reported probable anxiety across assessments, 54–58% probable depression, and 14–19% reported suicidal ideation on at least “several days” of the previous 2 weeks. Thirty-five percent reported probable COVID-19-related PTSD at baseline, decreasing to 24% by day 90. Other studies that surveyed psychopathology in HCWs found lower rates of anxiety (13–23%) and depression (18–23%) [
4,
9,
41,
42]. One possible explanation may be the fluctuating but persisting and enduring course of the COVID-19 pandemic in the United States, generating greater stress, burnout, and moral injury that in turn increased anxiety and depression. An alternative explanation may relate to the absence of uniform COVID-19 policy in the United States during this time frame, which may have amplified psychopathology and moral injury. It is also possible that differences between HWC samples could account for the higher rates of psychopathology in our study. As moral injury has never been surveyed in the general population, this study provided an opportunity to explore moral injury in a civilian, albeit highly stressed and traumatized, sample.
Our findings emphasize the need for early detection and treatment of mental health difficulties among healthcare workers. Unfortunately, healthcare workers are often reluctant to seek mental health care, which increases the need for an intervention to facilitate their treatment-seeking intentions. Among barriers to care, stigma toward treatment is a profound obstacle, as some may perceive receiving treatment as a weakness or a failure to meet social or one’s own expectations [
43,
44]. Long after the pandemic eventually loosens its grip, the psychiatric effects on HCWs may well not subside, leaving HCWs vulnerable and in need of assistance [
19,
45,
46]. Studies are needed to examine how to increase the likelihood of seeking care, which is essential during this COVID-19 crisis.
Limitations
Our study has several limitations. First, findings are limited to Amazon Mechanical Turk participants, who may not fully represent the HCW population, as they include mostly nurses (68%) and women (74%), compared to 30% registered nurses and 73% women in the healthcare occupation. Furthermore, 73% of participants described themselves as White, 13% as African American, and 11% as Asian, and 10% reported Hispanic ethnicity. These percentages are slightly divergent from the overall US population 2020 Census report of 72% White, 21% African American, 5% Asian, and 10% Hispanic. Second, clinical assessments, based on self-report questionnaires rather than formal diagnostic interview, were subject to over- or under-reporting [
47]. Third, while the COVID-19 virus widely struck the US, our data lacked specific information on exposure to COVID-19 phenomena (e.g., exposure to death). Fourth, we lacked statistical power to compare HCW subgroups. Lastly, although moral injury appears not to be an exclusively military-related contrast, future studies need to establish the incremental validity of morally injurious outcomes, relative to symptoms of PTSD.
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