Erschienen in:
01.12.2000 | Paper Report
Critical role of a stimulator/responder ratio between dendritic cells and CD4+ T cells for Th2 polarization
verfasst von:
Petya Dimitrova
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Based on origin and nature of stimulation during maturation, dendritic cells (DCs) can differentiate into either DC type 1 (DC1) or DC type 2 (DC2) that induce Th1 or Th2 responses, respectively. It has previously been suggested that human monocyte-derived DCs develop into DC1, secrete high amounts of interleukin (IL)-12 in response to pathogens or pathogen-derived signals and thus promote Th1 differentiation. In this paper, the ability of human myeloid dendritic cells to induce polarized Th1 or Th2 cell differentiation was investigated. …