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Current Reviews in Musculoskeletal Medicine

Erschienen in:

31.07.2018 | Prosthetic Joint Infection (S Nodzo and N Frisch, section editors)

Current Recommendations for the Diagnosis of Acute and Chronic PJI for Hip and Knee—Cell Counts, Alpha-Defensin, Leukocyte Esterase, Next-generation Sequencing

verfasst von: Karan Goswami, Javad Parvizi, P. Maxwell Courtney

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 3/2018

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Abstract

Purpose of Review

Despite significant progress in recent years, the diagnosis of periprosthetic joint infection (PJI) remains a challenge and no gold standard test exists. A combination of serological, synovial, microbiological, histological, and radiological investigations is performed that are expensive, often invasive, and imperfect. Novel biomarkers and molecular methods have shown promise in recent years. The purpose of this review is to provide an update about the diagnostic recommendations for PJI and cover a selection of emerging diagnostic tools.

Recent Findings

Recent literature highlights a new evidence-based definition for diagnosing hip and knee PJI that shows excellent performance on formal external multi-institutional validation. There is also increasing evidence to support the measurement of selected biomarkers in serum and synovial fluid, such as alpha-defensin, D-dimer, and interleukin-6. Finally, the emerging utility of next-generation sequencing for pathogen identification is discussed.

Summary

In summary, we describe current recommendations and emerging tests for the diagnosis of PJI. Residual limitations and directions for future research are also discussed.

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Titel: Current Recommendations for the Diagnosis of Acute and Chronic PJI for Hip and Knee—Cell Counts, Alpha-Defensin, Leukocyte Esterase, Next-generation Sequencing
verfasst von: Karan Goswami
Javad Parvizi
P. Maxwell Courtney
Publikationsdatum: 31.07.2018
Verlag: Springer US
Erschienen in: Current Reviews in Musculoskeletal Medicine / Ausgabe 3/2018
Elektronische ISSN: 1935-9748
DOI: https://doi.org/10.1007/s12178-018-9513-0

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Weitere Artikel der Ausgabe 3/2018

Low-Virulence Organisms and Periprosthetic Joint Infection—Biofilm Considerations of These Organisms

Intraoperative Considerations for Treatment/Prevention of Prosthetic Joint Infection

Current Concepts in Talar Neck Fracture Management

Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond

Risk Factors and Treatment Options for Failure of a Two-Stage Exchange

Posterior Cruciate Ligament Avulsion Fractures

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Update Orthopädie und Unfallchirurgie