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Erschienen in: Digestive Diseases and Sciences 6/2007

01.06.2007 | Original Paper

Da-Cheng-Qi-Tang Promotes the Recovery of Gastrointestinal Motility After Abdominal Surgery in Humans

verfasst von: Qing Hui Qi, Jian Wang, Guo Gang Liang, Xian Zhong Wu

Erschienen in: Digestive Diseases and Sciences | Ausgabe 6/2007

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Abstract

In order to examine the effects of Da-Cheng-Qi-Tang (DCQT) on gastrointestinal motility functions after abdominal surgery in humans, 33 patients with abdominal surgeries and 36 patients with cholecystectomies were divided into the DCQT and the control groups at random. Electrogastrography (EGG) and gastroduodenojejunal manometry was performed and the levels of plasma motilin were measured by radioimmunoassay. The results were as follows: (1) on the day of surgery, the ratio of EGG normal frequency in the DCQT group was higher than in the control group (P=0.0016); (2) the power of EGG in the DCQT group was higher than in the control group on the second and third days after surgeries (P=0.0011 and P=0.0215, respectively); (3) the percentage of normal bowel peristalsis was significantly higher in the DCQT group than in the control group (P<0.01); and (4) in the DCQT group, the plasma motilin level reached its peak earlier than in the control group. Our results suggest that DCQT can increase plasma motilin, enhance gastrointestinal motility, improve gastric dysrythmia, and reduce gastroparesis after abdominal surgery.
Literatur
2.
Zurück zum Zitat Moss G, Regal ME, Lichtig LK (1986) Reducing postoperative pain, narcotics, and length of hospitalization. Surgery 90:206–210 Moss G, Regal ME, Lichtig LK (1986) Reducing postoperative pain, narcotics, and length of hospitalization. Surgery 90:206–210
3.
Zurück zum Zitat Luckey A, Livingston E, Tache Y (2003) Mechanisms and treatment of postoperative ileus. Arch Surg 138:206–214PubMedCrossRef Luckey A, Livingston E, Tache Y (2003) Mechanisms and treatment of postoperative ileus. Arch Surg 138:206–214PubMedCrossRef
4.
Zurück zum Zitat Deloof P, Croix G (1988) The role of vasoactive intestinal polypeptide in the inhibition of antral and pyloric electrical activity in rabbits. J Auto Nerv Syst 22:167–173CrossRef Deloof P, Croix G (1988) The role of vasoactive intestinal polypeptide in the inhibition of antral and pyloric electrical activity in rabbits. J Auto Nerv Syst 22:167–173CrossRef
5.
Zurück zum Zitat Holzer P, Lippe IT (1986) Inhibition of gastrointestinal transit due to surgical trauma or peritoneal irritation is reduced in capsaicin-treated rats. Gastroenterology 91:360–363PubMed Holzer P, Lippe IT (1986) Inhibition of gastrointestinal transit due to surgical trauma or peritoneal irritation is reduced in capsaicin-treated rats. Gastroenterology 91:360–363PubMed
6.
Zurück zum Zitat Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ (2000) Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology 118:316–327PubMedCrossRef Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ (2000) Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology 118:316–327PubMedCrossRef
7.
Zurück zum Zitat Kalff JC, Carlos TM, Schraut WH (1999) Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology 117:378–387PubMedCrossRef Kalff JC, Carlos TM, Schraut WH (1999) Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology 117:378–387PubMedCrossRef
8.
Zurück zum Zitat Ogilvy AJ, Smith G (1995) The gastrointestinal tract after anesthesia. Eur J Anaesthesiol Suppl 10:35–42PubMed Ogilvy AJ, Smith G (1995) The gastrointestinal tract after anesthesia. Eur J Anaesthesiol Suppl 10:35–42PubMed
9.
Zurück zum Zitat Schurizek BA, Willacy LHO, Kraglund K, Andreasen F, Juhl B (1989) Effects of general anesthesia with enflurane on antroduodenal motility. Eur J Anaesthesiol 6:265–279PubMed Schurizek BA, Willacy LHO, Kraglund K, Andreasen F, Juhl B (1989) Effects of general anesthesia with enflurane on antroduodenal motility. Eur J Anaesthesiol 6:265–279PubMed
10.
Zurück zum Zitat Lin XM, Levanon D, Chen JDZ (1998) Impaired postprandial gastric slow waves in patients with functional dyspepsia. Dig Dis Sci 43:1678–1684PubMedCrossRef Lin XM, Levanon D, Chen JDZ (1998) Impaired postprandial gastric slow waves in patients with functional dyspepsia. Dig Dis Sci 43:1678–1684PubMedCrossRef
11.
Zurück zum Zitat Hocking MP. Vogel SB (1991) Physiology of gastric secretion and motility in normal and postgastrectomy (post vagotomy) states. In: Woodward’s postgastrectomy syndromes. 2nd ed. Hocking MP, Vogel SB (eds). W. B. Saunders, Philadelphia, pp 29–46 Hocking MP. Vogel SB (1991) Physiology of gastric secretion and motility in normal and postgastrectomy (post vagotomy) states. In: Woodward’s postgastrectomy syndromes. 2nd ed. Hocking MP, Vogel SB (eds). W. B. Saunders, Philadelphia, pp 29–46
12.
Zurück zum Zitat Abell TL, Malagelda JR (1988) Electrogasterography, current assessment and future perspective. Dig Dis Sci 33:982–992PubMedCrossRef Abell TL, Malagelda JR (1988) Electrogasterography, current assessment and future perspective. Dig Dis Sci 33:982–992PubMedCrossRef
13.
Zurück zum Zitat Familoni BO, Kingma YJ, Bowes KL (1987) A study of transcutaneous and intraluminal measurements of gastric electrical activity in humans. Med Biol Eng Comput 25:397–402PubMedCrossRef Familoni BO, Kingma YJ, Bowes KL (1987) A study of transcutaneous and intraluminal measurements of gastric electrical activity in humans. Med Biol Eng Comput 25:397–402PubMedCrossRef
14.
Zurück zum Zitat Hamilton JW, Bellahsene BE, Reicheidefer M (1986) Human electrogastrograms comparison of surface and mucosal recordings. Dig Dis Sci 31:33–39PubMedCrossRef Hamilton JW, Bellahsene BE, Reicheidefer M (1986) Human electrogastrograms comparison of surface and mucosal recordings. Dig Dis Sci 31:33–39PubMedCrossRef
15.
Zurück zum Zitat Familoni BO, Bowes KL, Kingma YJ, Cote KR (1991) Can transcutaneous recordings detect gastric electrical abnormalities? Gut 32:141–146PubMed Familoni BO, Bowes KL, Kingma YJ, Cote KR (1991) Can transcutaneous recordings detect gastric electrical abnormalities? Gut 32:141–146PubMed
16.
Zurück zum Zitat Mintchev MP, Kingma YJ, Bowes KL (1993) Accuracy of cutaneous recordings of gastric electrical activity. Gastroenterology 104:1273–1280PubMed Mintchev MP, Kingma YJ, Bowes KL (1993) Accuracy of cutaneous recordings of gastric electrical activity. Gastroenterology 104:1273–1280PubMed
17.
Zurück zum Zitat Koch KL, Stern RM, Vasey M, Botti JJ, Creasey GW, Dwey A (1990) Gastric dysrhythmia and nausea of pregnancy. Dig Dis Sci 35:961–968PubMedCrossRef Koch KL, Stern RM, Vasey M, Botti JJ, Creasey GW, Dwey A (1990) Gastric dysrhythmia and nausea of pregnancy. Dig Dis Sci 35:961–968PubMedCrossRef
18.
Zurück zum Zitat Livingston EH, Passaro EP (1990) Postoperative ileus. Dig Dig Sci 35:121–131CrossRef Livingston EH, Passaro EP (1990) Postoperative ileus. Dig Dig Sci 35:121–131CrossRef
19.
Zurück zum Zitat Marshall FN, Pittenger CB, Long JP (1961) Effects of halothane on gastrointestinal motility. Anesthesiology 22:363–366PubMedCrossRef Marshall FN, Pittenger CB, Long JP (1961) Effects of halothane on gastrointestinal motility. Anesthesiology 22:363–366PubMedCrossRef
20.
Zurück zum Zitat Bueno L, Ferre JP, Ruchebusch Y (1998) Effects of anesthesia and surgical procedures of intestinal myoelectric activity in rats. Am J Dig Dis 23:690–695CrossRef Bueno L, Ferre JP, Ruchebusch Y (1998) Effects of anesthesia and surgical procedures of intestinal myoelectric activity in rats. Am J Dig Dis 23:690–695CrossRef
21.
Zurück zum Zitat De Jone WJ, The FO, Der Coelen DV, Bennik RJ, Reitsma PH, Van Deventer SJ, VanDen Wijngaard RM, Boeckxstaens GE (2004) Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice. Gastroenterology 127:535–545CrossRef De Jone WJ, The FO, Der Coelen DV, Bennik RJ, Reitsma PH, Van Deventer SJ, VanDen Wijngaard RM, Boeckxstaens GE (2004) Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice. Gastroenterology 127:535–545CrossRef
22.
Zurück zum Zitat Kalff JC, Schraut WH, Simmons RH (1998) Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg 228:652–663PubMedCrossRef Kalff JC, Schraut WH, Simmons RH (1998) Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg 228:652–663PubMedCrossRef
23.
Zurück zum Zitat Xiang YM (1984) Improved preparation of “da-cheng-qi-tang” and its clinical use. Zhong Yao Tong Bao 9:123–124PubMed Xiang YM (1984) Improved preparation of “da-cheng-qi-tang” and its clinical use. Zhong Yao Tong Bao 9:123–124PubMed
24.
Zurück zum Zitat Xiong ZY (1984) Clinical application and therapeutic principal of “Da cheng qi tang.” Zhong Xi Yi Jie He Za Zhi 4:60–62PubMed Xiong ZY (1984) Clinical application and therapeutic principal of “Da cheng qi tang.” Zhong Xi Yi Jie He Za Zhi 4:60–62PubMed
25.
Zurück zum Zitat Chen HL, Wu XZ, Guan FL, Pei DK (2000) Protective effects of Tongli Gongxia herbs on gut barrier in rat with multiple organ dysfunction syndrome. Zhong Guo Zhong Xi Yi Jie He Za Zhi 20:120–122 Chen HL, Wu XZ, Guan FL, Pei DK (2000) Protective effects of Tongli Gongxia herbs on gut barrier in rat with multiple organ dysfunction syndrome. Zhong Guo Zhong Xi Yi Jie He Za Zhi 20:120–122
26.
Zurück zum Zitat Kang Y, Gao SD, Wu XZ (1991) Da Cheng Qi Tong on 45Ca content of isolated colon smooth muscle from experimental colon obstruction rats. Zhong Xi Yi Jie He Za Zhi 11:107–109PubMed Kang Y, Gao SD, Wu XZ (1991) Da Cheng Qi Tong on 45Ca content of isolated colon smooth muscle from experimental colon obstruction rats. Zhong Xi Yi Jie He Za Zhi 11:107–109PubMed
27.
Zurück zum Zitat Condon RE, Cowles VE, Schulte WJ, Frantozides CT, Mohoney SL (1986) Sarna SK:Resolution of postoperative ileus in humans. Ann Surg. 203:574–581PubMedCrossRef Condon RE, Cowles VE, Schulte WJ, Frantozides CT, Mohoney SL (1986) Sarna SK:Resolution of postoperative ileus in humans. Ann Surg. 203:574–581PubMedCrossRef
28.
Zurück zum Zitat Woods JH, Erickson LW, Condon RE, Schulte WJ, Sillin LF (1978) Postoperative Ileus:a colonic problem. Surgery 84:527–533PubMed Woods JH, Erickson LW, Condon RE, Schulte WJ, Sillin LF (1978) Postoperative Ileus:a colonic problem. Surgery 84:527–533PubMed
29.
Zurück zum Zitat Brown JC, Cook MA, Dryburgh JR (1972) Motilin, a gastric motor activity-stimulating polypeptide: final purification, amino acid composition, and C-terminal residues. Gastroenterology 62:401–404PubMed Brown JC, Cook MA, Dryburgh JR (1972) Motilin, a gastric motor activity-stimulating polypeptide: final purification, amino acid composition, and C-terminal residues. Gastroenterology 62:401–404PubMed
30.
Zurück zum Zitat Schubert H, Brown JC (1974) Correction to the amino acid sequence of porcine motilin. Can J Biochem 52(1):7–8PubMedCrossRef Schubert H, Brown JC (1974) Correction to the amino acid sequence of porcine motilin. Can J Biochem 52(1):7–8PubMedCrossRef
31.
Zurück zum Zitat Guan Y, Tang M, Jiang Z, Peeters TL (2003) Excitatory effects of motilin in the hippocampus on gastric motility in rats. Brain Res 984:33–41PubMedCrossRef Guan Y, Tang M, Jiang Z, Peeters TL (2003) Excitatory effects of motilin in the hippocampus on gastric motility in rats. Brain Res 984:33–41PubMedCrossRef
32.
Zurück zum Zitat Sasaki N, Yoshihara T (1999) The effect of motilin on the regulation mechanism of intestinal motility in conscious horses. J Vet Med Sci 61:167–170PubMedCrossRef Sasaki N, Yoshihara T (1999) The effect of motilin on the regulation mechanism of intestinal motility in conscious horses. J Vet Med Sci 61:167–170PubMedCrossRef
Metadaten
Titel
Da-Cheng-Qi-Tang Promotes the Recovery of Gastrointestinal Motility After Abdominal Surgery in Humans
verfasst von
Qing Hui Qi
Jian Wang
Guo Gang Liang
Xian Zhong Wu
Publikationsdatum
01.06.2007
Erschienen in
Digestive Diseases and Sciences / Ausgabe 6/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-007-9751-2

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