Lacquer cracks (LCs) are linear breaks in the retinal pigment epithelium (RPE) and / or Bruch’s membrane (BM), are usually located at the posterior pole, and are risk factors for progression of myopic maculopathy [
1]. In 1988, Klein and Green postulated a mechanical stretching and rupture of the BM-RPE-choriocapillaris complex as cause for LCs [
2]. Recent clinical and histological findings supported the notion of BM playing a biomechanical role in the etiology of myopic axial elongation [
3]. In the posterior fundus, BM has with the Bruch’s membrane opening (BMO) a physiologic defect which forms the inner layer of the optic nerve head canal. Recent studies suggested that during myopic axial elongation in non-highly myopic eyes, BMO shifts backward, leading to an overhanging of BM into the intrapapillary region of the optic nerve head at the nasal disc border, and an absence of BM in the temporal parapapillary region [
4]. That BM-free area has been called gamma zone [
3]. With further axial elongation leading to high myopia, BMO enlarges so that the intrapapillarily overhanging part of BM is retracted and a circular gamma zone develops. It has been discussed that the backward shift of the BMO may be caused by a BM enlargement in the equatorial region, and that the BMO enlargement is due to an axial elongation-associated increase in the strain within BM in the posterior fundus region [
3]. This increased BM strain has also been regarded as causative for the development of LCs as linear BM defects, eventually progressing to areolar BM defects in eyes with myopic maculopathy. A recent study suggested that a larger BMO in highly myopic eyes was associated with a lower prevalence of secondary macular BM defects [
4]. It led to the hypothesis, that a reduction in the BM strain by a sufficiently large increase in the BMO (i.e., a gamma zone enlargement) may prevent the development of additional macular BM defects. Fitting with this hypothesis, we here report on a highly myopic patient who showed a disappearance of a LC during a 10-year follow-up, concurrent with a marked increase in gamma zone.