Introduction
Methods
Study design
Panelist selection
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Practicing psychiatrist.
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Seen a minimum of 10 patients with schizophrenia in the last two years.
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Has published in the area of schizophrenia.
Preparation
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Outline of the Delphi Panel statement framework (developed from a targeted literature review including guidelines for LAI use, naturalistic prospective studies, non-interventional clinical trials, systematic literature reviews, and randomized controlled trials).
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Discussion of analysis rules for consensus statements.
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Suggestion of additional experts to participate as panelists.
Section 1: Patient population | Section 2: Dosage, management & adverse events | Section 3: Functional recovery domains & assessment |
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• Generic LAI use • Potential exclusions • Appropriateness for FEP and EP patients | • Adverse event management • Psychotic episodes on LAI • Loss of efficacy • LAI dosing & intervals for FEP and EP patients | • Long-term treatment goals • LAI links to functional recovery • Functional recovery domain • Functional recovery assessment • Achieved functional recovery |
Procedure
Survey development
Round 1
Rounds 2 and 3
Data analysis and definition of consensus
Rule 1: Questions that show a variable response pattern (≤ 40%) spread across response options in a non-skewed way will be removed |
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Rule 2: Questions with responses between 41% and 79% will be re-asked with three response options: Disagree, Neutral, Agree |
Rule 3: Questions that showed a skewed response pattern, with the majority of responses (≥ 80%) spread across 5 or 3 options, will be summed and asked back with a binary response option: Agree or Disagree |
Rule 4: Binary questions that showed a response pattern of ≥ 80% agreement will be considered consensus |
Rule 5: 3-point Likert scale questions in Round 2 with responses between 41% and 79% will be re-asked on a 3-point Likert scale in Round 3 |
Rule 6: 3-point Likert scale questions in Round 3 with ≥ 80% of a response option will be considered consensus |
Results
Participation in the survey
Overview of results
Top consensus topics | Top dissensus topics |
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Section 1 – Patient population | |
• Generic LAI use • Appropriateness for FEP and EP patients | • Potential exclusions |
Section 2 – Dosage, management & adverse events
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• Adverse event management | |
Section 3 – Functional recovery domains & assessment
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• Long-term treatment goals • LAI links to functional recovery • Functional recovery domain |