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08.05.2020 | Review

Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis

verfasst von: Vonetta M. Dotson, Shawn M. McClintock, Paul Verhaeghen, Joseph U. Kim, Amanda A. Draheim, Sarah M. Syzmkowicz, Andrew M. Gradone, Hannah R. Bogoian, Liselotte De Wit

Erschienen in: Neuropsychology Review | Ausgabe 4/2020

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Abstract

Depression has been shown to negatively impact neurocognitive functions, particularly those governed by fronto-subcortical networks, such as executive functions. Converging evidence suggests that depression-related executive dysfunction is greater at older ages, however, this has not been previously confirmed by meta-analysis. We performed a systematic review and meta-analysis, using three-level models, on peer-reviewed studies that examined depression-related differences in cognitive control in healthy community-dwelling individuals of any age. We focused on studies of cognitive control as defined by the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) framework, which centers on goal-directed behavior, such as goal selection (updating, representations, maintenance), response selection (inhibition or suppression), and performance monitoring. In 16,806 participants aged 7 to 97 across 76 studies, both clinical depression and subthreshold depressive symptoms were associated with cognitive control deficits (Hedges’ g = -0.31). This relationship was stronger in study samples with an older mean age. Within studies with a mean age of 39 years or higher, which represents the median age in our analyses, the relationship was stronger in clinical compared to subthreshold depression and in individuals taking antidepressant medication. These findings highlight the importance of clinicians screening for cognitive control dysfunction in patients with depression, particularly in later stages of adulthood.

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Titel: Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis
verfasst von: Vonetta M. Dotson
Shawn M. McClintock
Paul Verhaeghen
Joseph U. Kim
Amanda A. Draheim
Sarah M. Syzmkowicz
Andrew M. Gradone
Hannah R. Bogoian
Liselotte De Wit
Publikationsdatum: 08.05.2020
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 4/2020
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-020-09436-6

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Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis

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