Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Abdominal Radiology
Erschienen in: Abdominal Radiology 5/2010

01.10.2010

Detection of colo-rectal liver metastases: prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1.5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents

verfasst von: Pier Paolo Mainenti, Marcello Mancini, Ciro Mainolfi, Luigi Camera, Simone Maurea, Antonietta Manchia, Michela Tanga, Francesco Persico, Pietro Addeo, Dario D’Antonio, Antonio Speranza, Luigi Bucci, Giovanni Persico, Leonardo Pace, Marco Salvatore

Erschienen in: Abdominal Radiology | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

To compare contrast-enhanced US (CE-US), multidetector-CT (MDCT), 1.5 Tesla MR with extra-cellular (Gd-enhanced) and intracellular (SPIO-enhanced) contrast agents and PET/CT, in the detection of hepatic metastases from colorectal cancer.

Materials and methods

A total of 34 patients with colo-rectal adenocarcinoma underwent preoperatively CE-US, MDCT, Gd- and SPIO-enhanced MR imaging (MRI), and PET/CT. Each set of images was reviewed independently by two blinded observers. The ROC method was used to analyze the results, which were correlated with surgical findings, intraoperative US, histopathology, and MDCT follow-up.

Results

A total of 57 hepatic lesions were identified: 11 hemangiomas, 29 cysts, 1 focal fatty liver, 16 metastases (dimensional distribution: 5/16 < 5 mm; 3/16 between 5 mm and <10 mm; 8/16 ≥ 10 mm). Six of 34 patients were classified as positive for the presence of at least one metastasis. Considering all the metastases and those ≥10 mm, ROC areas showed no significant differences between Gd- and SPIO-enhanced MRI, which performed significantly better than the other modalities (P < 0.05). Considering the lesions <10 mm, ROC areas showed no significant differences between all modalities; however MRI presented a trend to perform better than the other techniques. Considering the patients, ROC areas showed no significant differences between all the modalities; however PET/CT seemed to perform better than the others.

Conclusions

Gd- and SPIO-enhanced MRI seem to be the most accurate modality in the identification of liver metastases from colo-rectal carcinoma. PET/CT shows a trend to perform better than the other modalities in the identification of patients with liver metastases.
Literatur
1.
Fong Y, Cohen AM, Fortner JG, et al. Liver resection for colorectal metastases. J Clin Oncol 1997; 15: 938-946.PubMed
2.
Nakamura S, Suzuky S, Baba S. Resection of liver metastases of colorectal carcinoma. World J Surg 1997; 21: 741-747.CrossRefPubMed
3.
Lehnert T, Knabel HP, Duck M, et al. Sequential hepatic and pulmonary resections for metastatic colorectal cancer. Br J Surg 1999; 86: 241-243.CrossRefPubMed
4.
Tanada M, Saeki T, Takashima S, et al. Intrahepatic arterial infusion chemotherapy for the colon cancer patients with liver metastases: a comparison of arterial embolization chemotherapy versus continuous arterial infusion chemotherapy. Gan to Kagaku Ryoho 1996; 23: 1440-1442.PubMed
5.
Dodd GD III, Soulen MC, Kane Rane, et al. Minimally Invasive treatment of malignant hepatic tumors: at the threshold of a major break through. Radiographics 2000; 20: 9-27.PubMed
6.
Ruers T, Bleichrodt RP. Treatment of liver metastases, an updater on the possibilities and results. Eur J Cancer 2002; 38: 1023-1033.CrossRefPubMed
7.
Kinkel K, Lu Y, Both M, Warren RS, Thoeni RF. Detection of Hepatic Metastases from Cancer of the Gastrointestinal tract by using non invasive imaging methods (US, CT, MR Imaging, PET): a meta-analysis. Radiology 2002; 224: 748-756.CrossRefPubMed
8.
Bipat S, van Leeuwen MS, Comans EFI, et al. Colorectal liver metastases: CT, MR imaging, and PET for diagnosis-Meta-analysis. Radiology 2005; 237: 123-131.CrossRefPubMed
9.
Couinaud C. Controlled hepatectomies and exposure of the intrahepatic bile ducts. Paris, France: C. Couinaud, 1981: 9-27.
10.
Wernecke K, Rummeny E, Bongartz G, et al. Detection of hepatic masses in patients with carcinoma: comparative sensitivities of sonography, CT, and MR imaging. Am J Roentgenol 1991; 157: 731-739.
11.
Glover C, Douse P, Kane P, et al. Accuracy of investigations for asymptomatic colorectal liver metastases. Dis Colon Rectum 2002; 45: 476-484.CrossRefPubMed
12.
Clarke MP, Kane RA, Steele G Jr, et al. Prospective comparison of preoperative imaging and intraoperative ultrasonography in the detection of liver tumors. Surgery 1989; 106: 849-855.PubMed
13.
Ohlsson B, Tranberg KG, Lundstedt C, et al. Detection of hepatic metastases in colorectal cancer: a prospective study of laboratory and imaging methods. Eur J Surg 1993; 159: 275-281.PubMed
14.
Albrecht T, Hoffmann CW, Schmitz SA, et al. Phase-inversion sonography during the liver-specific late phase of contrast enhancement: improved detection of liver metastases. Am J Roentgenol 2001; 176: 1191-1198.
15.
Albrecht T, Blomley MJ, Burns PN, et al. Improved detection of hepatic metastases with pulse-inversion US during the liver-specific phase of SHU 508A: multicenter study. Radiology 2003; 227: 361-370.CrossRefPubMed
16.
Esteban JM, Molla MA, Tomas C, Maldonado L. Improved detection of liver metastases with contrast-enhanced wideband harmonic imaging: comparison with CT findings. Eur J Ultrasound 2002; 15: 119-126.CrossRefPubMed
17.
Quaia E, D’Onofrio M, Palumbo A, Rossi S, Bruni S, Cova M. Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence. Eur Radiol 2006; 16: 1599-1609.CrossRefPubMed
18.
Dalla Palma L, Bertolotto M, Quaia E, Locatelli M. Detection of liver metastases with pulse inversion harmonic imaging: preliminary results. Eur Radiol 1999; 9 (Suppl. 3): S382-387.CrossRefPubMed
19.
Celli N, Gaiani S, Piscaglia F, et al. Characterization of liver lesions by real-time contrast-enhanced ultrasonography. Eur J Gastroenterol Hepatol 2007; 19: 3-14.CrossRefPubMed
20.
Larsen LP, Rosenkilde M, et al. The value of contrast enhanced ultrasonography in detection of liver metastases from colorectal cancer: A prospective double-blinded study. European Journal of Radiology 2007; 62: 302-307.CrossRefPubMed
21.
22.
Weg N, Scheer MR, Gabor MP. Liver lesions: improved detection with dual-detector-array CT and routine 2.5-mm thin collimation. Radiology 1998; 209: 417-426.PubMed
23.
Kawata S, Murakami T, Kim T, et al. Multidetector CT: diagnostic impact of slice thickness on detection of hypervascular hepatocellular carcinoma. Am J Roentgenol 2002; 179: 61-66.
24.
Haider MA, Amitai MM, Rappaport DC et al. Multidetector row helical CT in preoperative assessment of small (<1.5 cm) liver metastases: is thinner collimation better?. Radiology 2002; 225: 137-142.CrossRefPubMed
25.
Abdelmoumene A, Chevallier P, Chalaron M, et al. Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT). Eur Radiol 2005; 15: 1881-1887.CrossRefPubMed
26.
Scott DJ, Guthrie JA, Arnold P, et al. Dual phase helical CT versus portal venous phase CT for the detection of colorectal liver metastases; correlation with intra-operative sonography, surgical and pathological finings. Clin Radiol 2001; 56: 235-42.CrossRefPubMed
27.
Valls C, Andıa E, Sanchez A, et al. Hepatic metastases from colorectal cancer: preoperative assessment of resectability with helical CT. Radiology 2001; 218: 55-60.PubMed
28.
Valls C, Lopez E, Guma A, et al. Helical CT versus CT arterial portography in the detection of hepatic metastasis of colorectal carcinoma. Am J Roentgenol 1998; 170: 1341-1347.
29.
Kim SH, Choi D, Kim SH, et al. Ferucarbotran-enhanced MRI versus triple- phase MDCT for the preoperative detection of hepatocellular carcinoma. Am J Roentgenol 2005; 184: 1069-76.
30.
Numminen K, Isoniemi H, Halavaara J, et al. Preoperative assessment of focal liver lesions: multidetector computed tomography challenges magnetic resonance imaging. Acta Radiol 2005; 46: 9-15.CrossRefPubMed
31.
Ward J, Robinson PJ, Ashley Guthrie J, et al. Liver metastases in candidates for hepatic resection: comparison of helical CT and gadolinium- and SPIO-enhanced MR imaging. Radiology 2005; 237: 170-180.CrossRefPubMed
32.
Krakora GA, Coakley FV, Williams G, Yeh BM, Breiman RS, Qayyum A. Small hypoattenuating hepatic lesions at contrast-enhanced CT: prognostic importance in patients with breast cancer. Radiology 2004; 233: 667-673.CrossRefPubMed
33.
Kim YK, Ko SW, Hwang SB, Kim CS, Yu HC. Detection and characterization of liver metastases: 16–slice multidetector computed tomography versus superparamagnetic iron oxide–enhanced magnetic resonance imaging. Eur Radiol 2006; 16: 1337-1345.CrossRefPubMed
34.
Ruers TJ, Langenhoff BS, Neeleman N, et al. Value of Positron Emission Tomography with F18-Fluorodeoxyglucose in patients with colorectal liver metastases: a prospective study. Journal of Clinical Oncology, 2002; 15: 388-395.CrossRef
35.
Rappeport ED, Loft A, Berthelsen AK, et al. Contrast-Enhanced 18FDG-PET/CT vs. SPIO-Enhanced MRI vs. 18FDG-PET vs. CT in Patients with Liver Metastases from Colorectal Cancer: A Prospective Study with Intraoperative Confirmation Acta Radiol 2007; 4: 369-78.CrossRef
36.
Fong Y, Saldinger PF, Akhurst T, et al. Utility of 18F-FDG positron emission tomography scanning on selection of patients for resection of hepatic colorectal metastases. Am J Surg 1999; 178: 282-287.CrossRefPubMed
37.
Sahani DV, Kalva SP, Fischman AJ, Kadavigere R, Blake M, Hahn PF. Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET. Am J Roentgenol 2005; 185: 239-246.
38.
Selzner M, Hany TF, Wildbrett P, et al. Does the novel PET/CT imaging modality impact on the treatment of patients with metastatic colorectal cancer of the liver? Ann Surg 2004; 240: 1027-1035.CrossRefPubMed
39.
Chua SC, Groves AM, Kayani I, et al. The impact of 18F-FDG PET/CT in patients with liver metastases. Eur J Nucl Med Mol Imaging 2007; 34: 1906-1914.CrossRefPubMed
40.
Ward J, Chen F, Guthrie JA, et al. Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis. Radiology 2000; 214: 159-166.PubMed
41.
Ba-Ssalamah A, Heinz-Peer G, Schima W, et al. Detection of focal hepatic lesions: comparison of unenhanced and SHU 555 A-enhanced MR imaging versus biphasic helical CTAP. J Magn Reson Imaging 2000; 11: 665-672.CrossRefPubMed
42.
Blakeborough A, Ward J, Wilson D, et al. Hepatic lesion detection at MR imaging: a comparative study with four sequences. Radiology 1997; 203: 759-765.PubMed
43.
del Frate C, Bazzocchi M, Mortele KJ, et al. Detection of liver metastases: comparison of gadobenate dimeglumine-enhanced MR imaging examinations. Radiology 2002; 225: 766-772.CrossRefPubMed
44.
Furuhata T, Okita K, Tsuruma T, et al. Efficacy of SPIOMR imaging in the diagnosis of liver metastases from colorectal carcinomas. Dig Surg 2003; 20: 321-325.CrossRefPubMed
45.
Hagspiel KD, Neidl KF, Eichenberger AC, et al. Detection of liver metastases: comparison of superparamagnetic iron oxide enhanced and unenhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutaneous US. Radiology 1995; 196: 471-478.PubMed
46.
Kim HJ, Kim KW, Byun JH, et al. Comparison of mangafodipir trisodium- and ferucarbotran-enhanced MRI for detection and characterization of hepatic metastases in colorectal cancer patients. Am J Roentgenol 2006; 186: 1059-1066.CrossRef
47.
Kim YK, Lee JM, Kim CS, et al. Detection of liver metastases: gadobenate dimeglumine-enhanced three dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced-MR imaging. Eur Radiol 2005; 15: 220-228.CrossRefPubMed
48.
Lencioni R, Donati F, Cioni D, et al. Detection of colorectal liver metastases: prospective comparison of unenhanced and ferumoxides-enhanced magnetic resonance imaging at 1.5 T, dual phase spiral CT, and spiral CT during arterial portography. MAGMA 1998; 7: 76-83.CrossRefPubMed
49.
Van Beers BE, Lacrosse M, Jamart J, et al. Detection and segmental location of malignant hepatic tumors: comparison of ferumoxides-enhanced gradient-echo and T2-weighted spin-echo MR imaging. Am J Roentgenol 1997; 168: 713-717.
50.
Ward J, Naik KS, Guthrie JA, et al. Hepatic lesion detection: comparison of superparamagnetic iron oxide with dual-phase CT by using alternative-free response receiver operating characteristic analyses. Radiology 1999; 210: 459-466.PubMed
51.
Ward J, Guthrie JA, Wilson D, et al. Colorectal hepatic metastases: detection with SPIO-enhanced breath-hold MR imaging-comparison of optimized sequences. Radiology 2003; 228: 709-718.CrossRefPubMed
52.
Ch’en IY, Katz DS, Jeffrey RB Jr, et al. Do arterial phase helical CT images improve detection or characterization of colorectal liver metastases? J Comput Assist Tomogr 1997; 21: 391-397.CrossRefPubMed
Metadaten
Titel
Detection of colo-rectal liver metastases: prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1.5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents
verfasst von
Pier Paolo Mainenti
Marcello Mancini
Ciro Mainolfi
Luigi Camera
Simone Maurea
Antonietta Manchia
Michela Tanga
Francesco Persico
Pietro Addeo
Dario D’Antonio
Antonio Speranza
Luigi Bucci
Giovanni Persico
Leonardo Pace
Marco Salvatore
Publikationsdatum
01.10.2010
Verlag
Springer-Verlag
Erschienen in
Abdominal Radiology / Ausgabe 5/2010
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-009-9555-2

Weitere Artikel der Ausgabe 5/2010

Abdominal Radiology 5/2010 Zur Ausgabe

OriginalPaper

Comparison of CT colonography vs. conventional colonoscopy in mapping the segmental location of colon cancer before surgery

OriginalPaper

Diagnostic accuracy of CT colonography and optical colonoscopy evaluated using surgically resected specimens

OriginalPaper

Adnexal torsion: color Doppler and three-dimensional ultrasound

OriginalPaper

Flat lesions in CT colonography

Report

Ileocecal herniation through the foramen of Winslow: MDCT diagnosis

OriginalPaper

In vivo identification of uric acid stones with dual-energy CT: diagnostic performance evaluation in patients

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise