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09.11.2018 | Head and Neck

Detection of intralabyrinthine abnormalities using post-contrast delayed 3D-FLAIR MRI sequences in patients with acute vestibular syndrome

verfasst von: Michael Eliezer, Charles Maquet, Julien Horion, André Gillibert, Michel Toupet, Benoit Bolognini, Nicolas Magne, Laureline Kahn, Charlotte Hautefort, Arnaud Attyé

Erschienen in: European Radiology | Ausgabe 6/2019

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Abstract

Purpose

3D-FLAIR sequences with delayed acquisition after contrast medium injection have demonstrated new insights into blood-labyrinthine barrier (BLB) abnormalities in various diseases. The aim of this study was to assess the BLB in patients referred with unilateral acute vestibular syndrome (UAVS).

Materials and methods

In this retrospective multicenter imaging study, we performed 3D-FLAIR and steady-state free precession (SSFP) sequences 4 h after contrast medium administration in 26 healthy volunteers and in 30 patients with UAVS. Two radiologists, blinded to the clinical data, independently assessed the asymmetrical enhancement of the labyrinthine structures and the vestibular nerve on 3D-FLAIR sequences, and the signal of the labyrinthine structures on SSFP sequences. Inter-reader agreement tests were performed.

Results

An asymmetrical enhancement of the semicircular canals was observed in 26 out of 30 ears (86.6%, p < 0.001) and never observed in healthy subjects. An asymmetrical enhancement of the vestibular nerve was never observed in either patients or healthy subjects. An asymmetrical enhancement of the cochlea was observed on the 3D-FLAIR sequence in 6 out of 30 ears only in the patients’ group (20%, p = 0.03) and always associated with an enhancement of at least one semicircular canal. A low signal on SSFP sequences was observed only in 11 out of 30 symptomatic ears (36.7%, p < 0.001), involving the utricle in 7 ears and the superior semicircular canal in 4 ears.

Conclusion

Patients with typical UAVS presented with semicircular canal enhancement on MRI, while an asymmetrical enhancement of the vestibular nerve was not displayed.

Trial registration

NCT02529475

Key Points

• Patients with typical vestibular neuronitis presented with semicircular canal enhancement on MRI in 87% of cases.

• An enhancement of the vestibular nerve was never displayed.

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Titel: Detection of intralabyrinthine abnormalities using post-contrast delayed 3D-FLAIR MRI sequences in patients with acute vestibular syndrome
verfasst von: Michael Eliezer
Charles Maquet
Julien Horion
André Gillibert
Michel Toupet
Benoit Bolognini
Nicolas Magne
Laureline Kahn
Charlotte Hautefort
Arnaud Attyé
Publikationsdatum: 09.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5825-0

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Detection of intralabyrinthine abnormalities using post-contrast delayed 3D-FLAIR MRI sequences in patients with acute vestibular syndrome

Abstract

Purpose

Materials and methods

Results

Conclusion

Trial registration

Key Points

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Abstract

Purpose

Materials and methods

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