Adhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people’s living human immunodeficiency virus. Though manifold factors have reported as determinant factors of antiretroviral therapy adherence status, perhaps determinants of non-adherence differ up on the activities of patients in the study setting.
An institution based unmatched case–control study was conducted in Aksum town. Individuals who had a 6-month follow-up with complete individual information were included in the study. Document review and interviewer based techniques were used to collect the data. Binary logistic regression analysis was used to identify the determinant factors of non-adherence.
A total of 411 (137 cases and 274 control) study participants were included in the study. The majority of them were male in sex. Having 2 years and above duration on ART [AOR = 7, 95% CI (2.2, 22.6)], history of adverse effect [AOR = 6.9, 95% CI (1.4, 32.9)], substance use [AOR = 5.3, 95% CI (1.4, 20.0)], living with parents [AOR = 3.4, 95% CI (1.2, 10.3)], having depression symptom [AOR = 3.3, 95% CI (1.4, 7.5)], <350 cells/mm3 cluster of differentiation 4 count [AOR = 3.2, 95% CI (1.8, 5.8)] and low dietary diversity [AOR = 2, 95% CI (1.1, 3.7)] were found significant determinants of non-adherence to antiretroviral drug.
Program, social and individual related factors showed a statistically significant associated with non-adherence to antiretroviral therapy. Managing lifestyle by developing self-efficacy of individuals and treating related threat to improve adherence status of antiretroviral therapy is recommended in this study.
UNAIDS. The Gap Report Switzerland Geneva updated Sept 2014. July 2014.
HIV AIDS Prevention and Control Organization. Federal Democratic Republic of Ethiopia country progress report on the HIV response. Addis Ababa:MOH; 2014.
Joint United Nations Programme on HIV/AIDS. United Nation AIDS world AIDS day report 2011 (Faster, Smarter, Better). Geneva:UNAIDS; 2011.
Steel G, Nwokike J, Joshi MP. Development of a multi-method tool to measure ART adherence in resource-constrained settings: the South Africa experience. RPM Plus. Arlington, VA: Management Sciences for Health; 2007.
Asmare M, Aychiluhem M, Ayana M, Jara D. Level of ART adherence and associated factors among HIV sero-positive adult on highly active antiretroviral therapy in Debre Markos Referral Hospital, Northwest Ethiopia. J Antivir Antiretrovir. 2014;6:120–6. doi: 10.4172/jaa.10000107.
The World Health Organization. Global update on HIV treatment: results, impact and opportunities. 2013.
Tessema B, et al. Magnitude and determinants of non-adherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross-sectional study. AIDS Res Ther. 2010;7(1):1. CrossRef
Ethiopian Federal Minstry of Health. National Guidelines for Comprehensive HIV Prevention, Care and Treatment. Addis Ababa: Ethiopian Federal Minstry of Health; 2014.
Mitiku H, Abdosh T, Teklemariam Z. Factors affecting adherence to antiretroviral treatment in Harari National Regional State, eastern Ethiopia. ISRN AIDS. 2013;. doi: 10.1155/2013/960954.
Amberbir A, et al. Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia. BMC Public Health. 2008;8(1):1. CrossRef
Berhe N, Tegabu D, Alemayehu M. Effect of nutritional factors on adherence to antiretroviral therapy among HIV-infected adults: a case control study in northern Ethiopia. BMC Infect Dis. 2013;13(1):1. CrossRef
Bitew BD, et al. Determinants of none-adherence to antiretroviral therapy among HIV-infected adults in Arba Minch General Hospital, Gamo Gofa Zone, southern Ethiopia: a case control study. Am J Health Res. 2014;5(2):234–40. CrossRef
Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H, Centers for Disease Control and Prevention (CDC), National Institutes of Health, HIV Medicine Association of the Infectious Diseases Society of America. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. MMWR Recomm Rep. 2009;58(RR-4):1–207.
Machtinger EL, Bangsberg DR. Adherence to HIV antiretroviral therapy HIV InSite Knowledge Base chapter. 2006.
De Matteis A, et al. Baseline survey of food security and nutrition in Mozambique. Maputo: Technical Secretariat for Food Security and Nutrition: Vulnerability Analysis Group; 2006.
Kroenke K, Spitzer RL. The PHQ-9: a new depression diagnostic and severity measure. Psychiatr Ann. 2002;32(9):1–7. CrossRef
Irano ZA, et al. Determinants of non-adherence to antiretroviral therapy and modeling progression of adherence level: at Yirgalem Regional Hospital, Ethiopia; January, 2012. Int J Med Health Sci Res. 2015;2(1):1–14. CrossRef
Jiamsakul A, Kumarasamy N, Ditangco R, Li PC, Phanuphak P, Sirisanthana T, Sungkanuparph S, Kantipong P, Lee CK, Mustafa M, Merati T. Factors associated with suboptimal adherence to antiretroviral therapy in Asia. J Int AIDS Soc. 2014;17(1):18911. doi: 10.7448/IAS.17.1.18911. PubMedPubMedCentral
Wasti SP, et al. Factors influencing adherence to antiretroviral treatment in Asian developing countries: a systematic review. Tropl Med Int Health. 2012;17(1):71–81. CrossRef
Idindili B, Jullu B, Mugusi F, Tanner M. A case-control study of factors associated with non-adherent to antiretroviral therapy among HIV infected people in Pwani Region, eastern Tanzania. Tanzania J Health Res. 2012;14(3):194–203. CrossRef
Alagaw A, et al. Factors associated with antiretroviral treatment adherence among adult patients in Wolaita Soddo Hospital, Wolaita Zone, southern Ethiopia. Sci J Public Health. 2014;2:69–77.
Spire B, et al. Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment. Antivir Ther. 2008;13(5):697–703. PubMed
Peltzer K, et al. Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa. BMC Public Health. 2010;10(1):1. CrossRef
Mbuagbaw L, et al. Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: a systematic review and analysis of the CAMPS trial. AIDS Res Ther. 2012;9(1):1. CrossRef
Sasaki Y, et al. Adherence to antiretroviral therapy (ART) during the early months of treatment in rural Zambia: influence of demographic characteristics and social surroundings of patients. Ann Clin Microbiol Antimicrob. 2012;11(1):1. CrossRef
- Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia
Berhe Beyene Gebrezgabher
Yalemzewod Assefa Gelaw
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II