Erschienen in:
25.07.2016 | Letter to the Editor
Determination of the unbound fraction of R- and S-methadone in human brain
verfasst von:
Xiulu Ruan, Ken F. Mancuso, Alan David Kaye
Erschienen in:
International Journal of Legal Medicine
|
Ausgabe 2/2017
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Excerpt
We read with interest the article by Holm and Linnet [
1], entitled “Determination of the unbound fraction of R- and S-methadone in human brain” in the International
Journal of Legal Medicine. Based on the free drug hypothesis that only the unbound fraction (fu) of a given drug is biologically available in terms of its pharmacological activity, Holm and Linnet examined whether isolating the unbound fraction of the active R-methadone enantiomer from brain matter could be of value as a forensic tool. They found no overall correlation between the active R-methadone concentration and fu were found. Small but statistically significant differences in median fu for the R-methadone enantiomer were identified between case-categories (i.e., poisoning with multiple drugs, methadone poisoning, and deaths unrelated to methadone), but these are thought to be too low to be of any forensic value [
1]. …
