Erschienen in:
01.04.2015 | Diabetes, Other Diseases, and New Complications: Emerging Associations (JJ Nolan, Section Editor)
Diabetes and Epilepsy in Children and Adolescents
verfasst von:
M. Loredana Marcovecchio, Marianna Immacolata Petrosino, Francesco Chiarelli
Erschienen in:
Current Diabetes Reports
|
Ausgabe 4/2015
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Abstract
Over the last years, there has been an increasing interest in the potential association between type 1 diabetes (T1D) and epilepsy. Both T1D and epilepsy are common conditions in children and adolescents, and therefore, their association might represent simply a coincidence or be related to common underlying mechanisms with a potential causal relationship. Few epidemiological studies have been performed in the pediatric population, and they have reached discordant conclusions, with some studies reporting an increased prevalence of epilepsy in children and adolescents with T1D, whereas others have not confirmed this finding. Several mechanisms could explain the occurrence of epilepsy in young people with T1D, such as metabolic abnormalities (hypo/hyperglycemia) and autoantibodies, along with a genetic predisposition and the presence of brain lesions/damage. Further studies are required to better define whether there is a causal relationship between the two conditions and to understand the underlying mechanisms.