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Reviews in Endocrine and Metabolic Disorders

Erschienen in:

14.10.2021

Diabetes complications and extracellular vesicle therapy

verfasst von: Setareh Soltani, Kamran Mansouri, Shahram Parvaneh, Avnesh S. Thakor, Flemming Pociot, Reza Yarani

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 3/2022

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Abstract

Diabetes is a chronic disorder characterized by dysregulated glycemic conditions. Diabetic complications include microvascular and macrovascular abnormalities and account for high morbidity and mortality rates in patients. Current clinical approaches for diabetic complications are limited to symptomatic treatments and tight control of blood sugar levels. Extracellular vesicles (EVs) released by somatic and stem cells have recently emerged as a new class of potent cell-free therapeutic delivery packets with a great potential to treat diabetic complications. EVs contain a mixture of bioactive molecules and can affect underlying pathological processes in favor of tissue healing. In addition, EVs have low immunogenicity and high storage capacity while maintaining nearly the same regenerative and immunomodulatory effects compared to current cell-based therapies. Therefore, EVs have received increasing attention for diabetes-related complications in recent years. In this review, we provide an outlook on diabetic complications and summarizes new knowledge and advances in EV applications. Moreover, we highlight recommendations for future EV-related research.

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Titel: Diabetes complications and extracellular vesicle therapy
verfasst von: Setareh Soltani
Kamran Mansouri
Shahram Parvaneh
Avnesh S. Thakor
Flemming Pociot
Reza Yarani
Publikationsdatum: 14.10.2021
Verlag: Springer US
Erschienen in: Reviews in Endocrine and Metabolic Disorders / Ausgabe 3/2022
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-021-09680-y

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Diabetes complications and extracellular vesicle therapy

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