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01.08.2014 | Original Article

Diffusion tensor imaging in extremely low birth weight infants managed with hypercapnic vs. normocapnic ventilation

verfasst von: Xiawei Ou, Charles M. Glasier, Raghu H. Ramakrishnaiah, Teresita L. Angtuaco, Sarah B. Mulkey, Zhaohua Ding, Jeffrey R. Kaiser

Erschienen in: Pediatric Radiology | Ausgabe 8/2014

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Abstract

Background

Permissive hypercapnia is a ventilatory strategy used to prevent lung injury in ventilated extremely low birth weight (ELBW, birth weight ≤1,000 g) infants. However, there is retrospective evidence showing that high CO₂ is associated with brain injury.

Objective

The objective of this study was to compare brain white matter development at term-equivalent age in ELBW infants randomized to hypercapnic vs. normocapnic ventilation during the first week of life and in healthy non-ventilated term newborns.

Materials and methods

Twenty-two ELBW infants from a randomized controlled trial were included in this study; 11 received hypercapnic (transcutaneous PCO₂ [tcPCO₂] 50–60 mmHg) ventilation and 11 normocapnic (tcPCO₂ 35–45 mmHg) ventilation during the first week of life while still intubated. In addition, ten term healthy newborns served as controls. Magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) was performed at term-equivalent age for the ELBW infants and at approximately 2 weeks of age for the control infants. White matter injury on conventional MRI was graded in the ELBW and control infants using a scoring system adopted from literature. Tract-based spatial statistics (TBSS) was used to evaluate for differences in DTI measured fractional anisotropy (FA, spatially normalized to a customized template) among the ELBW and term control infants.

Results

Conventional MRI white matter scores were not different (7.3 ± 1.7 vs. 6.9 ± 1.4, P = 0.65) between the hypercapnic and normocapnic ELBW infants. TBSS analysis did not show significant differences (P < 0.05, corrected) between the two ELBW infant groups, although before multiple comparisons correction, hypercapnic infants had many regions with lower FA and no regions with higher FA (P < 0.05, uncorrected) compared to normocapnic infants. When compared to the control infants, normocapnic ELBW infants had a few small regions with significantly lower FA, while hypercapnic ELBW infants had more widespread regions with significantly lower FA (P < 0.05, fully corrected for multiple comparisons).

Conclusions

Normocapnic ventilation vs. permissive hypercapnia may be associated with improved white matter development at term-equivalent age in ELBW infants. This effect, however, was small and was not apparent on conventional MRI. Further research is needed using larger sample sizes to assess if permissive hypercapnic ventilation in ELBW infants is associated with worse white matter development.

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Titel: Diffusion tensor imaging in extremely low birth weight infants managed with hypercapnic vs. normocapnic ventilation
verfasst von: Xiawei Ou
Charles M. Glasier
Raghu H. Ramakrishnaiah
Teresita L. Angtuaco
Sarah B. Mulkey
Zhaohua Ding
Jeffrey R. Kaiser
Publikationsdatum: 01.08.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 8/2014
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-014-2946-8

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Diffusion tensor imaging in extremely low birth weight infants managed with hypercapnic vs. normocapnic ventilation