Erschienen in:
01.10.2010 | Letter
Direct antimicrobial activity of antithrombin?
verfasst von:
Christian J Wiedermann, Angela Djanani
Erschienen in:
Critical Care
|
Ausgabe 5/2010
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Excerpt
In a study by Hofstra and colleagues [
1] in a recent issue of
Critical Care, nebulization of drotrecogin-alfa (activated), antithrombin, heparin, or danaparoid attenuated pulmonary coagulopathy during
Streptococcus pneumoniae pneumonia in rats; only antithrombin additionally exerted lung-protective effects and reduced bacterial outgrowth. Adding antithrombin to culture medium had no effect on the outgrowth of S. pneumoniae
in vitro; thus, less neutralizing of endogenous antimicrobicidals by reduced bronchoalveolar fluid levels of inflammatory proteins could have permitted better endogenous microbicidal effects in the antithrombin group [
1]. …