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Neuroradiology

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29.08.2018 | Functional Neuroradiology

Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study

verfasst von: Qi Han, Yang Zhang, Daihong Liu, Yao Wang, Yajin Feng, Xuntao Yin, Jian Wang

Erschienen in: Neuroradiology | Ausgabe 11/2018

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Abstract

Purpose

The study aimed to investigate the abnormal alterations of both the intra-regional brain activity and inter-regional functional connectivity (FC) in patients with subjective tinnitus (ST) using resting-state functional MRI (rs-fMRI) methods.

Methods

Twenty-five ST patients and 25 normal controls (NCs) were included and underwent resting-state functional magnetic resonance imaging scans. ReHo, fALFF, and seed-based FC were calculated and compared between ST patients and NCs. Meanwhile, correlation analyses were calculated between altered connectivity and clinical data in ST patients.

Results

Compared with NCs, ST patients exhibited increased ReHo and fALFF values in the right middle temporal gyrus (MTG), and the ReHo values were also increased in the right cuneus. In contrast, decreased ReHo values in ST patients were observed in the right middle frontal gyrus (MFG) and left cerebellar anterior lobe. Considering these brain areas with altered ReHo and fALFF clusters as seeds, the right MTG (ReHo) exhibited decreased connectivity with the right MFG, lingual gyrus, and left cerebellar posterior lobe, besides, the right cuneus showed decreased connectivity with the right MTG. In ST patients, the decreased FC between the right MTG (ReHo) and the right MFG was also positively correlated with the Tinnitus handicap inventory score (r = 0.675, P = 0.001).

Conclusion

The present study revealed that ST patients had altered regional neural activity and inter-regional connectivity in partial auditory and non-auditory brain regions, mainly involving the default mode network and audio-visual network, which could further improve our understanding of the neuroimaging mechanism in ST.

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Titel: Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study
verfasst von: Qi Han
Yang Zhang
Daihong Liu
Yao Wang
Yajin Feng
Xuntao Yin
Jian Wang
Publikationsdatum: 29.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Neuroradiology / Ausgabe 11/2018
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2087-0

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Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study

Abstract

Purpose

Methods

Results

Conclusion

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