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European Radiology

Erschienen in:

28.11.2015 | Magnetic Resonance

Disrupted white matter structure underlies cognitive deficit in hypertensive patients

verfasst von: Xin Li, Chao Ma, Xuan Sun, Junying Zhang, Yaojing Chen, Kewei Chen, Zhanjun Zhang

Erschienen in: European Radiology | Ausgabe 9/2016

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Abstract

Objectives

Hypertension is considered a risk factor of cognitive impairments and could result in white matter changes. Current studies on hypertension-related white matter (WM) changes focus only on regional changes, and the information about global changes in WM structure network is limited.

Methods

We assessed the cognitive function in 39 hypertensive patients and 37 healthy controls with a battery of neuropsychological tests. The WM structural networks were constructed by utilizing diffusion tensor tractography and calculated topological properties of the networks using a graph theoretical method. The direct and indirect correlations among cognitive impairments, brain WM network disruptions and hypertension were analyzed with structural equation modelling (SEM).

Results

Hypertensive patients showed deficits in executive function, memory and attention compared with controls. An aberrant connectivity of WM networks was found in the hypertensive patients (P _Eglob = 0.005, P _Lp = 0.005), especially in the frontal and parietal regions. Importantly, SEM analysis showed that the decline of executive function resulted from aberrant WM networks in hypertensive patients (p = 0.3788, CFI = 0.99).

Conclusions

These results suggest that the cognitive decline in hypertensive patients was due to frontal and parietal WM disconnections. Our findings highlight the importance of brain protection in hypertension patients.

Key points

• Hypertension has a negative effect on the performance of the cognitive domains

• Reduced efficiencies of white matter networks were shown in hypertension

• Disrupted white matter networks are responsible for poor cognitive function in hypertension

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Titel: Disrupted white matter structure underlies cognitive deficit in hypertensive patients
verfasst von: Xin Li
Chao Ma
Xuan Sun
Junying Zhang
Yaojing Chen
Kewei Chen
Zhanjun Zhang
Publikationsdatum: 28.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4116-2

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Disrupted white matter structure underlies cognitive deficit in hypertensive patients

Abstract

Objectives

Methods

Results

Conclusions

Key points

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Objectives

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Conclusions

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