Background
Methods
Search strategy and inclusion criteria
Data extraction and quality assessment
Data synthesis and analysis
Results
Study search and characteristics of the included patients
Author, year | Patients’ Diagnosis | Surgery | Study Design | Enrolled sample number | Mean age, years | Outcome measurement | Quality assessment |
---|---|---|---|---|---|---|---|
Pochettino et al., 2000 [1] | COPD | Lung Transplant | Retrospective Case–control | DLT: 46 SLT: 84 | DLT: 51.1 ± 1.2 SLT: 56.2 ± 0.7 | Functional assessment, overall survival, and survival following onset of BOS | 7 |
Meyer et al., 2001 [20] | Emphysema/COPD | Lung Transplant | Retrospective cohort (ISHLT/UNOS database) | DLT: 425 SLT: 1835 | DLT: 50.5 ± 7.1 SLT: 54.8 ± 6.3 | Mortality and Morbidity analysis | 8 |
Cassivi et al., 2002 [21] | COPD/AATD | Lung Transplant | Retrospective Case–control | DLT: 112 SLT: 228 | Total: 55.2 ± 6.4 | Survival, Posttransplant functional result, morbidity | 7 |
Burton et al., 2005 [22] | All suitable for lung transplant cases | Lung Transplant | Retrospective Case–control | DLT: 228 SLT: 112 | (Median) DLT: 45 SLT: 56 | Survival rates for the center as a whole and compared survival rates between different sub-groups of patients | 7 |
Hadjiliadis et al., 2006 [24] | COPD/AATD | Lung Transplant | Retrospective cohort (2 centers) | DLT: 103 SLT: 118 | DLT: 53.0 ± 7.8 SLT: 55.3 ± 8.0 | The effect of transplant on the development of BOS, survival, and survival after BOS in patients with COPD and alpha-1-antitrypsin deficiency | 7 |
Gunes et al., 2006 [23] | COPD | Lung Transplant | Retrospective Case–control | DLT: 99 SLT: 66 | Total: 50 ± 6 | Outcomes of lung transplant for COPD (A-1 & cigarette smoking) | 7 |
Stavem et al., 2006 [25] | All suitable for lung transplant cases | Lung Transplant | Retrospective Case–control | DLT: 37 SLT: 49 | Total: 49.6 ± 8.9 | The impact of diagnosis, SLT vs BLT, and the timing of transplant on the survival of patients placed on the waiting list for lung transplantation in Norway from 1990 to 2003 | 7 |
Nwakanma et al., 2007 [26] | All suitable for lung transplant cases over 60 years old | Lung Transplant | Retrospective Cohort (UNOS) | DLT: 224 SLT: 863 | (All Diagnosis) DLT: 62.3 ± 2.1 SLT: 62.8 ± 2.5 | The impact of procedure type on short- and mid-term survival in recipients 60 years of age or older for all disease types | 7 |
Thabut et al., 2008 (Am J Respir Crit Care Med) [27] | COPD | Lung Transplant | Retrospective Cohort (UNOS) | Total: 5873 DLT: 27.8% SLT: 72.2% | Total: 56.0 ± 7.1 | Analyze data from the UNOS registry to (1) determine the survival (2) patients with COPD most likely to benefit from LT (3) create an instrument for caregivers to compute the expected survival effect of LT for a given patient | 7 |
Thabut et al., 2008 (Lancet) [2] | COPD | Lung Transplant | Retrospective Cohort (ISHLT) | DLT: 3525 SLT: 6358 | DLT: 52.2 ± 7.8 SLT: 55.5 ± 6.8 | Compare survival rates after bilateral and single lung transplantation for patients with COPD | 8 |
Delgado et al., 2009 [28] | Pulmonary emphysema | Lung Transplant | Retrospective Case–control | DLT: 33 SLT: 29 | Total: 53.89 ± 6.75 | Propose single lung transplant as the first-choice treatment for patients with a diagnosis of emphysema | 6 |
Bennett et al., 2015 [29] | COPD | Lung Transplant | Retrospective Case–control (Single-Center) and Cohort (UNOS) | DLT: 30 SLT: 206 (UNOS) DLT: 2848 | DLT: 58.89 ± 4.54 SLT: 52.41 ± 5.02 (UNOS) DLT: 57.48 ± 7.47 | Comparable 5-year survival among the single-center SLTx cohort and BLTx recipients at both the local and national levels | 8 |
Schaffer et al., 2015 [30] | COPD/IPF | Lung Transplant | Retrospective Cohort (ISHLT) | DLT: 1875 SLT: 1299 | DLT: 59.4 ± 6.4 SLT: 61.6 ± 5.5 | Reviewed UNOS data to summarize outcomes of IPF and COPD who underwent single- or double lung transplantation since the LAS was implemented | 8 |
Gulack et al., 2018 [31] | COPD/AATD | Lung Transplant | Retrospective Cohort (UNOS) | DLT: 5688 SLT: 3881 | (Median) DLT: 57 SLT: 58 | Hypothesized that patients with AATD have superior long-term survival following lung transplantation than patients with COPD | 8 |
Crawford et al., 2019 [32] | COPD | Lung Transplant | Retrospective Cohort (UNOS) | DLT: 2196 SLT: 1358 | DLT: 60 ± 6 SLT: 62 ± 5 | Evaluate survivals in lung transplant recipients with COPD among SLT and DLT cohorts | 8 |
Case–control Study | |||||||||
---|---|---|---|---|---|---|---|---|---|
Author, year | Selection | Comparability | Exposure | Quality assessment | |||||
Is the case definition adequate? | Representativeness of the cases | Selection of Controls | Definition of Controls | Comparability of cases and controls on the basis of the design or analysis | Ascertainment of exposure | Same method of ascertainment for cases and controls | Non-response rate | ||
Pochettino et al., 2000 [1] | * | * | * | ** | * | * | 7 | ||
Cassivi et al., 2002 [21] | * | * | * | ** | * | * | 7 | ||
Burton et al., 2005 [22] | * | * | * | ** | * | * | 7 | ||
Gunes et al., 2006 [23] | * | * | * | ** | * | * | 7 | ||
Stavem et al., 2006 [25] | * | * | * | ** | * | * | 7 | ||
Delgado et al., 2009 [28] | * | * | * | * | * | * | 6 | ||
Selection | Comparability | Exposure | Quality assessment | ||||||
Representativeness of the exposed cohort | Selection of the non-exposed cohort | Ascertainment of exposure | Demonstration that outcome of interest was not present at the start of study | Comparability of cohorts on the basis of the design or analysis | Assessment of outcome | Was follow-up long enough for outcomes to occur? | Adequacy of follow-up of cohorts | ||
Meyer et al., 2001 [20] | * | * | * | ** | * | * | * | 8 | |
Hadjiliadis et al., 2006 [24] | * | * | * | ** | * | * | * | 8 | |
Nwakanma et al., 2007 [26] | * | * | * | ** | * | * | 7 | ||
Thabut et al., 2008 (Am J Respir Crit Care Med) [27] | * | * | * | ** | * | * | 7 | ||
Thabut et al., 2008 (Lancet) [2] | * | * | * | ** | * | * | * | 8 | |
Bennett et al., 2015 [29] | * | * | * | ** | * | * | * | 8 | |
Schaffer et al., 2015 [30] | * | * | * | ** | * | * | * | 8 | |
Gulack et al., 2018 [31] | * | * | * | ** | * | * | * | 8 |