Erschienen in:
01.08.2014 | Letter to the Editor
E2F1: a potential therapeutic target for systematic lupus erythematosus
verfasst von:
Xin-yu Fang, Dong-qing Ye
Erschienen in:
Rheumatology International
|
Ausgabe 8/2014
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Abstract
E2F1 is a transcriptional activator, which binds to DNA, and regulates the expression of genes involved in the cell cycle progression. Many elegant studies have revealed that E2F1 plays a crucial role in regulating the apoptosis process of DC and T cells. In addition, the pathogenesis of SLE involves marked immune dysfunction, and in particular, the function of immunosuppressive elements of the immune system is impaired, including regulatory T cell function and DC. Thus, therapeutic agents targeting E2F1 might result in important innovative therapies for SLE.