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01.02.2011 | Case Based Review

Early onset systemic lupus erythematosus: differential diagnoses, clinical presentation, and treatment options

verfasst von: Christian Michael Hedrich, Hildegard Zappel, Simon Straub, Martin W. Laass, Kathrin Wieczorek, Gabriele Hahn, Georg Heubner, Manfred Gahr

Erschienen in: Clinical Rheumatology | Ausgabe 2/2011

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Abstract

Juvenile systemic lupus erythematosus is a rare multisystemic autoimmune disease with variable clinical manifestations, and disease onset before 16 years of age. Patients younger than 5 years are rarely affected and the age of onset may contribute to the course of disease in terms of clinical presentation, organ involvement, and serological findings. Here, we report two exemplary early-onset SLE patients, a 28-month-old patient with WHO class IIB kidney disease, arthritis, and a typical antibody constellation and an 11-month-old infant that presented with microcytic anemia, leukocytosis, arthritis, fasciitis, fatty liver disease, protein losing enteropathy, edema, and minimal change glomerulonephritis. Epidemiologic and clinical features of early-onset SLE compared to other forms of SLE are given and differential diagnoses and treatment options are discussed.

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Titel: Early onset systemic lupus erythematosus: differential diagnoses, clinical presentation, and treatment options
verfasst von: Christian Michael Hedrich
Hildegard Zappel
Simon Straub
Martin W. Laass
Kathrin Wieczorek
Gabriele Hahn
Georg Heubner
Manfred Gahr
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: Clinical Rheumatology / Ausgabe 2/2011
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-010-1576-2

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