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Graefe's Archive for Clinical and Experimental Ophthalmology

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04.08.2017 | Retinal Disorders

Early visual cortical structural changes in diabetic patients without diabetic retinopathy

verfasst von: Fábio S. Ferreira, João M. S. Pereira, Aldina Reis, Mafalda Sanches, João V. Duarte, Leonor Gomes, Carolina Moreno, Miguel Castelo-Branco

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 11/2017

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Abstract

Background

It is known that diabetic patients have changes in cortical morphometry as compared to controls, but it remains to be clarified whether the visual cortex is a disease target, even when diabetes complications such as retinopathy are absent. Therefore, we compared type 2 diabetes patients without diabetic retinopathy with control subjects using magnetic resonance imaging to assess visual cortical changes when retinal damage is not yet present.

Methods

We performed T1-weighted imaging in 24 type 2 diabetes patients without diabetic retinopathy and 27 age- and gender-matched controls to compare gray matter changes in the occipital cortex between groups using voxel based morphometry.

Results

Patients without diabetic retinopathy showed reduced gray matter volume in the occipital lobe when compared with controls.

Conclusions

Reduced gray matter volume in the occipital cortex was found in diabetic patients without retinal damage. We conclude that cortical early visual processing regions may be affected in diabetic patients even before retinal damage occurs.

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Titel: Early visual cortical structural changes in diabetic patients without diabetic retinopathy
verfasst von: Fábio S. Ferreira
João M. S. Pereira
Aldina Reis
Mafalda Sanches
João V. Duarte
Leonor Gomes
Carolina Moreno
Miguel Castelo-Branco
Publikationsdatum: 04.08.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 11/2017
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-017-3752-4

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Springer Medizin

Early visual cortical structural changes in diabetic patients without diabetic retinopathy

Abstract

Background

Methods

Results

Conclusions

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Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

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Update Augenheilkunde

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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