Skip to main content
Erschienen in: Neurocritical Care 2/2016

25.04.2016 | Original Article

Early Withdrawal Decision-Making in Patients with Coma After Cardiac Arrest: A Qualitative Study of Intensive Care Clinicians

verfasst von: Charlene J. Ong, Amar Dhand, Michael N. Diringer

Erschienen in: Neurocritical Care | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Neurologists are often asked to define prognosis in comatose patients. However, comatose patients following cardiac arrest are usually cared for by cardiologists or intensivists, and it is their approach that will influence decisions regarding withdrawal of life-sustaining interventions (WLSI). We observed that factors leading to these decisions vary across specialties and considered whether they could result in self-fulfilling prophecies and early WLSI. We conducted a hypothesis-generating qualitative study to identify factors used by non-neurologists to define prognosis in these patients and construct an explanatory model for how early WLSI might occur.

Methods

This was a single-center qualitative study of intensivists caring for cardiac arrest patients with hypoxic-ischemic coma. Thirty attending physicians (n = 16) and fellows (n = 14) from cardiac (n = 8), medical (n = 6), surgical (n = 10), and neuro (n = 6) intensive care units underwent semi-structured interviews. Interview transcripts were analyzed using grounded theory techniques.

Results

We found three components of early WLSI among non-neurointensivists: (1) development of fixed negative opinions; (2) early framing of poor clinical pictures to families; and (3) shortened windows for judging recovery potential. In contrast to neurointensivists, non-neurointensivists’ negative opinions were frequently driven by patients’ lack of consciousness and cardiopulmonary resuscitation circumstances. Both groups were influenced by age and comorbidities.

Conclusions

The results demonstrate that factors influencing prognostication differ across specialties. Some differ from those recommended by published guidelines and may lead to self-fulfilling prophecies and early WLSI. Better understanding of this framework would facilitate educational interventions to mitigate this phenomenon and its implications on patient care.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Levy DE, Caronna JJ, Singer BH, et al. Predicting outcome from hypoxic-ischemic coma. JAMA. 1985;253:1420–6.CrossRefPubMed Levy DE, Caronna JJ, Singer BH, et al. Predicting outcome from hypoxic-ischemic coma. JAMA. 1985;253:1420–6.CrossRefPubMed
2.
Zurück zum Zitat Wijdicks EF, Hijdra A, Young GB, et al. Quality Standards Subcommittee of the American Academy of N. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the quality standards subcommittee of the american academy of neurology. Neurology. 2006;67:203–10.CrossRefPubMed Wijdicks EF, Hijdra A, Young GB, et al. Quality Standards Subcommittee of the American Academy of N. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the quality standards subcommittee of the american academy of neurology. Neurology. 2006;67:203–10.CrossRefPubMed
3.
Zurück zum Zitat Nolan JP, Soar J, Zideman DA, et al. European resuscitation council guidelines for resuscitation 2010 section 1. Executive summary. Resuscitation. 2010;81:1219–76.CrossRefPubMed Nolan JP, Soar J, Zideman DA, et al. European resuscitation council guidelines for resuscitation 2010 section 1. Executive summary. Resuscitation. 2010;81:1219–76.CrossRefPubMed
4.
Zurück zum Zitat Sandroni C, Cariou A, Cavallaro F, et al. Prognostication in comatose survivors of cardiac arrest: an advisory statement from the european resuscitation council and the european society of intensive care medicine. Intensive Care Med. 2014;40:1816–31.CrossRefPubMedPubMedCentral Sandroni C, Cariou A, Cavallaro F, et al. Prognostication in comatose survivors of cardiac arrest: an advisory statement from the european resuscitation council and the european society of intensive care medicine. Intensive Care Med. 2014;40:1816–31.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Cook D, Rocker G, Marshall J, et al. Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med. 2003;349:1123–32.CrossRefPubMed Cook D, Rocker G, Marshall J, et al. Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med. 2003;349:1123–32.CrossRefPubMed
6.
Zurück zum Zitat Kowalski RG, Chang TR, Carhuapoma JR, et al. Withdrawal of technological life support following subarachnoid hemorrhage. Neurocrit Care. 2013;19:269–75.CrossRefPubMed Kowalski RG, Chang TR, Carhuapoma JR, et al. Withdrawal of technological life support following subarachnoid hemorrhage. Neurocrit Care. 2013;19:269–75.CrossRefPubMed
7.
Zurück zum Zitat Becker KJ, Baxter AB, Cohen WA, et al. Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology. 2001;56:766–72.CrossRefPubMed Becker KJ, Baxter AB, Cohen WA, et al. Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology. 2001;56:766–72.CrossRefPubMed
8.
Zurück zum Zitat Rocker G, Cook D, Sjokvist P, et al. Clinician predictions of intensive care unit mortality. Crit Care Med. 2004;32:1149–54.CrossRefPubMed Rocker G, Cook D, Sjokvist P, et al. Clinician predictions of intensive care unit mortality. Crit Care Med. 2004;32:1149–54.CrossRefPubMed
9.
Zurück zum Zitat Weimer JM, Nowacki AS, Frontera JA. Withdrawal of life-sustaining therapy in patients with intracranial haemorrhage: self-fulfilling prophecy or accurate prediction of outcome? Critical Care Medicine. 2016. Jan 20 [Epub ahead of print]. Weimer JM, Nowacki AS, Frontera JA. Withdrawal of life-sustaining therapy in patients with intracranial haemorrhage: self-fulfilling prophecy or accurate prediction of outcome? Critical Care Medicine. 2016. Jan 20 [Epub ahead of print].
10.
Zurück zum Zitat Frick S, Uehlinger DE, Zenklusen RMZ. Medical futility: predicting outcome of intensive care unit patients by nurses and doctors—a prospective comparative study. Crit Care Med. 2003;31:456–61.CrossRefPubMed Frick S, Uehlinger DE, Zenklusen RMZ. Medical futility: predicting outcome of intensive care unit patients by nurses and doctors—a prospective comparative study. Crit Care Med. 2003;31:456–61.CrossRefPubMed
11.
Zurück zum Zitat Christensen C, Cottrell JJ, Murakami J, et al. Forecasting survival in the medical intensive care unit: a comparison of clinical prognoses with formal estimates. Methods Inf Med. 1993;32:302–8.PubMed Christensen C, Cottrell JJ, Murakami J, et al. Forecasting survival in the medical intensive care unit: a comparison of clinical prognoses with formal estimates. Methods Inf Med. 1993;32:302–8.PubMed
12.
13.
Zurück zum Zitat Izzy S, Compton R, Carandang R, et al. Self-fulfilling prophecies through withdrawal of care: do they exist in traumatic brain injury too? Neurocrit Care. 2013;19:347–63.CrossRefPubMed Izzy S, Compton R, Carandang R, et al. Self-fulfilling prophecies through withdrawal of care: do they exist in traumatic brain injury too? Neurocrit Care. 2013;19:347–63.CrossRefPubMed
14.
Zurück zum Zitat Verkade MA, Nieuwenhoff MD, Kompanje EJO. Withdrawal of life-sustaining treatment in a mixed intensive care unit: most common in patients with catastrophic brain injury. Neurocrit Care. 2012;16:130135.CrossRef Verkade MA, Nieuwenhoff MD, Kompanje EJO. Withdrawal of life-sustaining treatment in a mixed intensive care unit: most common in patients with catastrophic brain injury. Neurocrit Care. 2012;16:130135.CrossRef
15.
Zurück zum Zitat Greer DM, Rosenthal ES, Wu O. Neuroprognostication of hypoxic-ischaemic coma in the therapeutic hypothermia era. Nat Rev Neurol. 2014;10:190–203.CrossRefPubMed Greer DM, Rosenthal ES, Wu O. Neuroprognostication of hypoxic-ischaemic coma in the therapeutic hypothermia era. Nat Rev Neurol. 2014;10:190–203.CrossRefPubMed
16.
Zurück zum Zitat Geocadin RG, Peberdy MA, Lazar RM. Poor survival after cardiac arrest resuscitation: a self-fulfilling prophecy or biologic destiny? Crit Care Med. 2012;40:979–80.CrossRefPubMed Geocadin RG, Peberdy MA, Lazar RM. Poor survival after cardiac arrest resuscitation: a self-fulfilling prophecy or biologic destiny? Crit Care Med. 2012;40:979–80.CrossRefPubMed
18.
19.
Zurück zum Zitat Fugate JE, Wijdicks EF, Mandrekar J, et al. Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann Neurol. 2010;68:907–14.CrossRefPubMed Fugate JE, Wijdicks EF, Mandrekar J, et al. Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann Neurol. 2010;68:907–14.CrossRefPubMed
21.
22.
Zurück zum Zitat Wilson ME, Rhudy LM, Ballinger BA, et al. Factors that contribute to physician variability in decisions to limit life support in the ICU: a qualitative study. Intensive Care Med. 2013;39:1009–18.CrossRefPubMed Wilson ME, Rhudy LM, Ballinger BA, et al. Factors that contribute to physician variability in decisions to limit life support in the ICU: a qualitative study. Intensive Care Med. 2013;39:1009–18.CrossRefPubMed
23.
Zurück zum Zitat Sprung CL, Cohen SL, Sjokvist P, et al. End of life practices in european intensive care units: the ethicus study. JAMA. 2003;290:790–7.CrossRefPubMed Sprung CL, Cohen SL, Sjokvist P, et al. End of life practices in european intensive care units: the ethicus study. JAMA. 2003;290:790–7.CrossRefPubMed
24.
Zurück zum Zitat Hemphill JC 3rd, White DB. Clinical nihilism in neuroemergencies. Emerg Med Clin N Am. 2009;27:27–37.CrossRef Hemphill JC 3rd, White DB. Clinical nihilism in neuroemergencies. Emerg Med Clin N Am. 2009;27:27–37.CrossRef
25.
Zurück zum Zitat Albaeni A, Chandra-Strobos N, Vaidya D, et al. Predictors of early care withdrawal following out-of-hospital cardiac arrest. Resuscitation. 2014;85:1455–61.CrossRefPubMed Albaeni A, Chandra-Strobos N, Vaidya D, et al. Predictors of early care withdrawal following out-of-hospital cardiac arrest. Resuscitation. 2014;85:1455–61.CrossRefPubMed
26.
27.
Zurück zum Zitat Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19:349–57.CrossRefPubMed Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19:349–57.CrossRefPubMed
28.
Zurück zum Zitat Kennedy TJ, Lingard LA. Making sense of grounded theory in medical education. Med Educ. 2006;40:101–8.CrossRefPubMed Kennedy TJ, Lingard LA. Making sense of grounded theory in medical education. Med Educ. 2006;40:101–8.CrossRefPubMed
29.
30.
Zurück zum Zitat Zier LS, Burack JH, Micco G, et al. Doubt and belief in physicians’ ability to prognosticate during critical illness: the perspective of surrogate decision makers. Crit Care Med. 2008;36:2341–7.CrossRefPubMedPubMedCentral Zier LS, Burack JH, Micco G, et al. Doubt and belief in physicians’ ability to prognosticate during critical illness: the perspective of surrogate decision makers. Crit Care Med. 2008;36:2341–7.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Christakis NA, Iwashyna TJ. Attitude and self-reported practice regarding prognostication in a national sample of internists. Arch Intern Med. 1998;158:2389–95.CrossRefPubMed Christakis NA, Iwashyna TJ. Attitude and self-reported practice regarding prognostication in a national sample of internists. Arch Intern Med. 1998;158:2389–95.CrossRefPubMed
32.
Zurück zum Zitat Meadow W, Pohlman A, Frain L, et al. Power and limitations of daily prognostications of death in the medical intensive care unit. Crit Care Med. 2011;39:474–9.CrossRefPubMed Meadow W, Pohlman A, Frain L, et al. Power and limitations of daily prognostications of death in the medical intensive care unit. Crit Care Med. 2011;39:474–9.CrossRefPubMed
33.
Zurück zum Zitat Mulder M, Gibbs HG, Smith SW, et al. Awakening and withdrawal of life-sustaining treatment in cardiac arrest survivors treated with therapeutic hypothermia. Crit Care Med. 2014;42:2493–9.CrossRefPubMedPubMedCentral Mulder M, Gibbs HG, Smith SW, et al. Awakening and withdrawal of life-sustaining treatment in cardiac arrest survivors treated with therapeutic hypothermia. Crit Care Med. 2014;42:2493–9.CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Callaway CW, Schmicker RH, Brown SP, et al. Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest. Resuscitation. 2014;85:657–63.CrossRefPubMedPubMedCentral Callaway CW, Schmicker RH, Brown SP, et al. Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest. Resuscitation. 2014;85:657–63.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Zandbergen EG, Hijdra A, Koelman JH, et al. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology. 2006;66:62–8.CrossRefPubMed Zandbergen EG, Hijdra A, Koelman JH, et al. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology. 2006;66:62–8.CrossRefPubMed
36.
Zurück zum Zitat Mark NM, Rayner SG, Lee NJ, Curtis JR. Global variability in withholding and withdrawal of life-sustaining treatment in the intensive care unit: a systematic review. Intensive Care Med. 2015;41:1572–85.CrossRefPubMed Mark NM, Rayner SG, Lee NJ, Curtis JR. Global variability in withholding and withdrawal of life-sustaining treatment in the intensive care unit: a systematic review. Intensive Care Med. 2015;41:1572–85.CrossRefPubMed
37.
Zurück zum Zitat Rogove HJ, Safar P, Sutton-Tyrrell K, Abramson NS. Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The brain resuscitation clinical trial i and ii study groups. Crit Care Med. 1995;23:18–25.CrossRefPubMed Rogove HJ, Safar P, Sutton-Tyrrell K, Abramson NS. Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The brain resuscitation clinical trial i and ii study groups. Crit Care Med. 1995;23:18–25.CrossRefPubMed
38.
Zurück zum Zitat Winther-Jensen M, Kjaergaard J, Hassager C, et al. Resuscitation and post resuscitation care of the very old after out-of-hospital cardiac arrest is worthwhile. Int J Cardiol. 2015;201:616–23.CrossRefPubMed Winther-Jensen M, Kjaergaard J, Hassager C, et al. Resuscitation and post resuscitation care of the very old after out-of-hospital cardiac arrest is worthwhile. Int J Cardiol. 2015;201:616–23.CrossRefPubMed
39.
Zurück zum Zitat Chan PS, Spertus JA, Krumholz HM, et al. A validated prediction tool for initial survivors of in-hospital cardiac arrest. Arch Intern Med. 2012;172:947–53.CrossRefPubMedPubMedCentral Chan PS, Spertus JA, Krumholz HM, et al. A validated prediction tool for initial survivors of in-hospital cardiac arrest. Arch Intern Med. 2012;172:947–53.CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Lopez-Rolon A, Bender A, Project HIG. Hypoxia and outcome prediction in early-stage coma (project hope): an observational prospective cohort study. BMC Neurol. 2015;15:82.CrossRefPubMedPubMedCentral Lopez-Rolon A, Bender A, Project HIG. Hypoxia and outcome prediction in early-stage coma (project hope): an observational prospective cohort study. BMC Neurol. 2015;15:82.CrossRefPubMedPubMedCentral
Metadaten
Titel
Early Withdrawal Decision-Making in Patients with Coma After Cardiac Arrest: A Qualitative Study of Intensive Care Clinicians
verfasst von
Charlene J. Ong
Amar Dhand
Michael N. Diringer
Publikationsdatum
25.04.2016
Verlag
Springer US
Erschienen in
Neurocritical Care / Ausgabe 2/2016
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-016-0275-5

Weitere Artikel der Ausgabe 2/2016

Neurocritical Care 2/2016 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.