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Journal of Assisted Reproduction and Genetics

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28.08.2019 | Commentary

Easing US restrictions on mitochondrial replacement therapy would protect research interests but grease the slippery slope

verfasst von: David L. Keefe

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 9/2019

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Mitochondria are essential organelles found in most eukaryotic cells [1, 2]. They play important roles not only in the production of cellular energy but also in metabolic [3], immune [4], neural [5], and psychiatric function [6, 7], as well as aging [2, 8]. Mitochondria originated billions of years ago as separate bacteria-like organisms, and over the intervening millennia developed symbiotic relationships with our eukaryotic ancestors. The relationship between mitochondria and eukaryotic cells has proven mutually beneficial, though at times precarious [9, 10]. Concordant with their origin as separate organisms, mitochondria contain their own DNA, called mitochondrial DNA [11] (mtDNA). mtDNA retains many features of bacterial DNA, including exquisite susceptibility to damage, rapid mutagenesis, and limited repair capacity. …

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Titel: Easing US restrictions on mitochondrial replacement therapy would protect research interests but grease the slippery slope
verfasst von: David L. Keefe
Publikationsdatum: 28.08.2019
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 9/2019
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-019-01529-3

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