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Abdominal Radiology

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02.01.2021 | Hepatobiliary

Effect of breath holding at the end of the inspiration and expiration phases on liver stiffness measured by 2D-MR elastography

verfasst von: Hao Ren, Dawei Yang, Hui Xu, Kai Pang, Yiwen Shi, Qiushuang Guan, Zhenghan Yang

Erschienen in: Abdominal Radiology | Ausgabe 6/2021

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Abstract

Purpose

Evaluate the effect of breath holding at the end of the inspiration and expiration phases on the measurement of liver stiffness by 2D-MR elastography (MRE).

Methods

The study included 61 subjects, of which 31 subjects were pathologically confirmed liver fibrosis patients [liver fibrosis group (LFG)] and 30 healthy subjects [healthy group (HG)]. MRE was used to measure the liver stiffness of subjects in inspiration breath-hold (IBH) and expiration breath-hold (EBH) states.

Results

In IBH and EBH states, the liver stiffness measured by MRE was not significantly different in the HG (P = 0.125, > 0.05), while the LFG showed a significant difference (P <0.001). Also, a significant difference was observed between the change values in the mild/moderate fibrosis group (MFG) and advanced fibrosis group (AFG) (P = 0.005, < 0.05).

Conclusions

The liver stiffness values in patients with liver fibrosis were affected by breath-holding states. The higher the stage of liver fibrosis, the greater the change in liver stiffness values, but no significant difference was observed between liver stiffness values in healthy subjects under the two breath-holding conditions. Different breath-holding states are factors influencing liver fibrosis stiffness measured by MRE, which should be given due attention in both clinical and research contexts.

Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol. 2014;14(3):181–194. https://doi.org/10.1038/nri3623CrossRefPubMed

Trautwein C, Friedman SL, Schuppan D, Pinzani M. Hepatic fibrosis: Concept to treatment. J Hepatol. 2015;62(1 Suppl):S15–S24. https://doi.org/10.1016/j.jhep.2015.02.039CrossRefPubMed

Marcellin P, Gane E, Buti M, et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2013;381(9865):468–475. https://doi.org/10.1016/S0140-6736(12)61425-1CrossRefPubMed

Lassailly G, Caiazzo R, Buob D, et al. Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients. Gastroenterology. 2015;149(2):379‐e16. https://doi.org/10.1053/j.gastro.2015.04.014CrossRef

Gonzalez HC, Jafri SM, Gordon SC. Role of liver biopsy in the era of direct-acting antivirals. Curr Gastroenterol Rep. 2013;15(2):307. https://doi.org/10.1007/s11894-012-0307-zCrossRefPubMed

Gilmore IT, Burroughs A, Murray-Lyon IM, Williams R, Jenkins D, Hopkins A. Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and the Royal College of Physicians of London. Gut. 1995;36(3):437–441. https://doi.org/10.1136/gut.36.3.437CrossRefPubMedPubMedCentral

Hennedige TP, Wang G, Leung FP, et al. Magnetic Resonance Elastography and Diffusion Weighted Imaging in the Evaluation of Hepatic Fibrosis in Chronic Hepatitis B. Gut Liver. 2017;11(3):401–408. https://doi.org/10.5009/gnl16079.CrossRefPubMed

Besa C, Wagner M, Lo G, et al. Detection of liver fibrosis using qualitative and quantitative MR elastography compared to liver surface nodularity measurement, gadoxetic acid uptake, and serum markers. J Magn Reson Imaging. 2018;47(6):1552–1561. https://doi.org/10.1002/jmri.25911.CrossRefPubMed

Choi YR, Lee JM, Yoon JH, Han JK, Choi BI. Comparison of magnetic resonance elastography and gadoxetate disodium-enhanced magnetic resonance imaging for the evaluation of hepatic fibrosis. Invest Radiol. 2013;48(8):607–613. https://doi.org/10.1097/RLI.0b013e318289ff8fCrossRefPubMed

10.

Kim D, Kim WR, Talwalkar JA, Kim HJ, Ehman RL. Advanced fibrosis in nonalcoholic fatty liver disease: noninvasive assessment with MR elastography. Radiology. 2013;268(2):411–419. https://doi.org/10.1148/radiol.13121193CrossRefPubMedPubMedCentral

11.

Loomba R, Wolfson T, Ang B, et al. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study [published correction appears in Hepatology. 2015 Nov;62(5):1646]. Hepatology. 2014;60(6):1920–1928. https://doi.org/10.1002/hep.27362CrossRefPubMedPubMedCentral

12.

Batheja M, Vargas H, Silva AM, et al. Magnetic resonance elastography (MRE) in assessing hepatic fibrosis: performance in a cohort of patients with histological data. Abdom Imaging. 2015;40(4):760–765. https://doi.org/10.1007/s00261-014-0321-8CrossRefPubMed

13.

Yoshimitsu K, Mitsufuji T, Shinagawa Y, et al. MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience. Eur Radiol. 2016;26(3):656–663. https://doi.org/10.1007/s00330-015-3863-4CrossRefPubMed

14.

Venkatesh SK, Talwalkar JA. When and how to use magnetic resonance elastography for patients with liver disease in clinical practice. Am J Gastroenterol. 2018;113(7):923–926. https://doi.org/10.1038/s41395-018-0012-0CrossRefPubMed

15.

Srinivasa Babu A, Wells ML, Teytelboym OM, et al. Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions. Radiographics. 2016;36(7):1987–2006. https://doi.org/10.1148/rg.2016160042CrossRefPubMedPubMedCentral

16.

Castera L, Foucher J, Bernard PH, et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology. 2010; 51:828–835. [PubMed: 20063276]

17.

Zhuo J, Gullapalli RP. AAPM/RSNA physics tutorial for residents: MR artifacts, safety, and quality control. Radiographics. 2006;26(1):275–297. https://doi.org/10.1148/rg.261055134CrossRefPubMed

18.

Yin M, Talwalkar JA, Glaser KJ, et al. Dynamic postprandial hepatic stiffness augmentation assessed with MR elastography in patients with chronic liver disease. AJR Am J Roentgenol. 2011;197(1):64–70. https://doi.org/10.2214/AJR.10.5989CrossRef

19.

Mueller S. Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis. World J Gastroenterol. 2016;22(48):10482–10501. https://doi.org/10.3748/wjg.v22.i48.10482CrossRefPubMedPubMedCentral

20.

Asbach P, Klatt D, Hamhaber U, et al. Assessment of liver viscoelasticity using multifrequency MR elastography. Magn Reson Med. 2008;60(2):373–379. https://doi.org/10.1002/mrm.21636CrossRefPubMed

21.

Huwart L, van Beers BE. MR elastography. Gastroenterol Clin Biol. 2008;32(6 Suppl 1):68–72. https://doi.org/10.1016/S0399-8320(08)73995-2CrossRefPubMed

22.

Yin M, Chen J, Glaser KJ, Talwalkar JA, Ehman RL. Abdominal magnetic resonance elastography. Top Magn Reson Imaging. 2009;20(2):79–87. https://doi.org/10.1097/RMR.0b013e3181c4737eCrossRefPubMedPubMedCentral

23.

Murphy IG, Graves MJ, Reid S, et al. Comparison of breath-hold, respiratory navigated and free-breathing MR elastography of the liver. Magn Reson Imaging. 2017;37:46–50. https://doi.org/10.1016/j.mri.2016.10.011CrossRefPubMed

24.

Altinkaya N, Koc Z, Ulusan S, Demir S, Gurel K. Effects of respiratory manoeuvres on hepatic vein Doppler waveform and flow velocities in a healthy population. Eur J Radiol. 2011;79(1):60–63. https://doi.org/10.1016/j.ejrad.2010.01.011CrossRefPubMed

25.

Richardson PD, Withrington PG. Liver blood flow. I. Intrinsic and nervous control of liver blood flow. Gastroenterology. 1981;81(1):159–173.CrossRef

26.

Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313–1321. https://doi.org/10.1002/hep.20701CrossRefPubMed

27.

Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 1996;24(2):289–293. https://doi.org/10.1002/hep.510240201CrossRefPubMed

28.

Bunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94(9):2467–2474. https://doi.org/10.1111/j.1572-0241.1999.01377.xCrossRef

29.

Kleiner DE, Brunt EM. Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research. Semin Liver Dis. 2012;32(1):3–13. https://doi.org/10.1055/s-0032-1306421CrossRefPubMed

30.

Silva AM, Grimm RC, Glaser KJ, et al. Magnetic resonance elastography: evaluation of new inversion algorithm and quantitative analysis method. Abdom Imaging. 2015;40(4):810–817. https://doi.org/10.1007/s00261-015-0372-5CrossRefPubMed

31.

Trout AT, Serai S, Mahley AD, et al. Liver Stiffness Measurements with MR Elastography: Agreement and Repeatability across Imaging Systems, Field Strengths, and Pulse Sequences. Radiology. 2016;281(3):793–804. https://doi.org/10.1148/radiol.2016160209CrossRefPubMed

32.

Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–191. https://doi.org/10.3758/bf03193146CrossRefPubMed

33.

Rabinovici N, Navot N. The relationship between respiration, pressure and flow distribution in the vena cava and portal and hepatic veins. Surg Gynecol Obstet. 1980;151(6):753–763.PubMed

34.

Millonig G, Friedrich S, Adolf S, et al. Liver stiffness is directly influenced by central venous pressure. J Hepatol. 2010;52(2):206–210. https://doi.org/10.1016/j.jhep.2009.11.018.CrossRefPubMed

35.

Wang K, Manning P, Szeverenyi N, et al. Repeatability and reproducibility of 2D and 3D hepatic MR elastography with rigid and flexible drivers at end-expiration and end-inspiration in healthy volunteers. Abdom Radiol (NY). 2017;42(12):2843–2854. https://doi.org/10.1007/s00261-017-1206-4CrossRef

36.

Yang YL, Di L, Duan YY, et al. A prospective experimental study of liver fibrosis with ultrasound and its correlation with hepatic reserve function and hemodynamics. BMC Gastroenterol. 2012;12:168. Published 2012 Nov 23. https://doi.org/10.1186/1471-230X-12-168CrossRefPubMedPubMedCentral

Titel: Effect of breath holding at the end of the inspiration and expiration phases on liver stiffness measured by 2D-MR elastography
verfasst von: Hao Ren
Dawei Yang
Hui Xu
Kai Pang
Yiwen Shi
Qiushuang Guan
Zhenghan Yang
Publikationsdatum: 02.01.2021
Verlag: Springer US
Erschienen in: Abdominal Radiology / Ausgabe 6/2021
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-020-02893-w

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Springer Medizin

Effect of breath holding at the end of the inspiration and expiration phases on liver stiffness measured by 2D-MR elastography

Abstract

Purpose

Methods

Results

Conclusions

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Update Radiologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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