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Neurological Sciences

Erschienen in:

01.03.2022 | Original Article

Effect of cognitive reserve on cognitive function in Parkinson’s disease

verfasst von: Lihua Gu, Hui Xu

Erschienen in: Neurological Sciences | Ausgabe 7/2022

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Abstract

Background

Previous studies showed inconsistent results for the correlation between cognitive reserve (CR) and cognitive function in Parkinson’s disease (PD). Additionally, conflicting results were obtained for the association between CR and risk of longitudinal cognitive decline, longitudinal progression to mild cognitive impairment (MCI), and longitudinal progression to dementia in PD patients.

Objectives

Thus, a meta-analysis is essential to summary these inconsistent results.

Methods

Articles published before November 2021 were searched in databases as follows: PubMed, Web of Science, Medline, EMBASE, and Google Scholar. We computed Fisher’s z score and standard error (SE) of each transformation value of correlation coefficient for the correlation between educational level and cognitive function. Additionally, odds ratios (ORs) or hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed as effect sizes for the correlation between educational level and risk of longitudinal progression to MCI.

Results

The present study showed that higher educational levels were related to better general cognitive function, executive function, memory, and information processing speed in PD patients, whereas no significant association was showed between educational levels and visuospatial function, language in PD patients. Additionally, included studies reported a negative association between educational level and risk of longitudinal progression to MCI in PD patients.

Conclusions

In conclusion, the study demonstrated that higher CR might be correlated with better cognitive function and lower risk of longitudinal progression to MCI in PD. In addition, large-scale prospective studies are necessary to explore the effect of CR on cognitive function in PD.

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Titel: Effect of cognitive reserve on cognitive function in Parkinson’s disease
verfasst von: Lihua Gu
Hui Xu
Publikationsdatum: 01.03.2022
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 7/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05985-1

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Abstract

Background

Objectives

Methods

Results

Conclusions

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