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European Journal of Nutrition

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25.06.2016 | Original Contribution

Effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats

verfasst von: Jing Chen, Wei Duan, Xin Ren, Chao Wang, Zhongli Pan, Xianmin Diao, Qun Shen

Erschienen in: European Journal of Nutrition | Ausgabe 6/2017

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Abstract

Purpose

The objective of this study was to determine the effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats (SHRs).

Methods

The protein of foxtail millet after extruding or fermenting and the raw foxtail millet was extracted and hydrolyzed by digestive protease to generate angiotensin-converting enzyme (ACE) inhibitory peptides. The potential antihypertensive effect of protein hydrolysates from foxtail millet in SHRs was investigated.

Results

After 4 weeks of treatment with 200 mg peptides/kg of body weight of protein hydrolysates, blood pressure was lowered significantly, and the raw and extruded samples were more effective than the fermented samples. The serum ACE activity and angiotensin II levels in the treatment groups were significantly lower than that of the control. The percent heart weight decreased in the treatment groups.

Conclusion

Thus, ingestion of foxtail millet protein hydrolysates especially for the raw and extruded hydrolysates may ameliorate hypertension and alleviate related cardiovascular diseases.

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Titel: Effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats
verfasst von: Jing Chen
Wei Duan
Xin Ren
Chao Wang
Zhongli Pan
Xianmin Diao
Qun Shen
Publikationsdatum: 25.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1252-7

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Effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats

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Purpose

Methods

Results

Conclusion

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