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Erschienen in: Current Bladder Dysfunction Reports 4/2015

01.12.2015 | Geriatric Bladder Dysfunction (GM Ghoniem, Section Editor)

Effect of Hormonal Changes on Voiding in the Elderly Woman

verfasst von: Esther Han, Priyanka Gupta, Jason P. Gilleran

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 4/2015

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Abstract

Hormonal loss after menopause result in changes that occur to the vaginal epithelium, which shares a common embryological origin with the lower urinary tract. These changes due to hypoestrogenism lead to symptoms of urinary frequency, urgency, incontinence, dysuria, and recurrent urinary tract infections. Replacement of estrogen can provide benefits to some of these conditions, but potential complications associated with the use of unopposed estrogen (including cardiovascular and oncogenic) have given clinicians pause for concern before administering it to patients without adequate counseling. This review article will examine the pathophysiology of the urogenital changes that occur after hormonal loss. We will discuss several well-designed trials that answer questions about the relationship between hormone replacement therapy and overactive bladder, stress incontinence, and recurrent urinary tract infections. In light of the controversy over estrogen therapy and patients’ warranted concerns about the risks, we will also discuss newer hormonal agents, their role in treating this condition, as well as how we counsel patients on a reasonable hormone replacement therapy (HRT) regimen.
Literatur
1.
Zurück zum Zitat Portman DJ, Gass ML, Panel VATCC. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and the North American Menopause Society. Maturitas. 2014;79(3):349–54.CrossRefPubMed Portman DJ, Gass ML, Panel VATCC. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and the North American Menopause Society. Maturitas. 2014;79(3):349–54.CrossRefPubMed
2.
Zurück zum Zitat Iosif CS, Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause. Acta Obstet Gynecol Scand. 1984;63(3):257–60.CrossRefPubMed Iosif CS, Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause. Acta Obstet Gynecol Scand. 1984;63(3):257–60.CrossRefPubMed
3.
Zurück zum Zitat Ingelman-Sundberg A, Rosén J, Gustafsson SA, Carlström K. Cytosol estrogen receptors in the urogenital tissues in stress-incontinent women. Acta Obstet Gynecol Scand. 1981;60(6):585–6.CrossRefPubMed Ingelman-Sundberg A, Rosén J, Gustafsson SA, Carlström K. Cytosol estrogen receptors in the urogenital tissues in stress-incontinent women. Acta Obstet Gynecol Scand. 1981;60(6):585–6.CrossRefPubMed
4.
Zurück zum Zitat Bernstein IT. The pelvic floor muscles: muscle thickness in healthy and urinary-incontinent women measured by perineal ultrasonography with reference to the effect of pelvic floor training. Estrogen receptor studies. Neurourol Urodyn. 1997;16(4):237–75.CrossRefPubMed Bernstein IT. The pelvic floor muscles: muscle thickness in healthy and urinary-incontinent women measured by perineal ultrasonography with reference to the effect of pelvic floor training. Estrogen receptor studies. Neurourol Urodyn. 1997;16(4):237–75.CrossRefPubMed
5.
Zurück zum Zitat Chen GD, Oliver RH, Leung BS, Lin LY, Yeh J. Estrogen receptor alpha and beta expression in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women. Fertil Steril. 1999;71(6):1099–102.CrossRefPubMed Chen GD, Oliver RH, Leung BS, Lin LY, Yeh J. Estrogen receptor alpha and beta expression in the vaginal walls and uterosacral ligaments of premenopausal and postmenopausal women. Fertil Steril. 1999;71(6):1099–102.CrossRefPubMed
6.
Zurück zum Zitat Robinson D, Cardozo LD. The role of estrogens in female lower urinary tract dysfunction. Urology. 2003;62(4 Suppl 1):45–51.CrossRefPubMed Robinson D, Cardozo LD. The role of estrogens in female lower urinary tract dysfunction. Urology. 2003;62(4 Suppl 1):45–51.CrossRefPubMed
7.
Zurück zum Zitat Hillard T. The postmenopausal bladder. Menopause Int. 2010;16(2):74–80.PubMed Hillard T. The postmenopausal bladder. Menopause Int. 2010;16(2):74–80.PubMed
8.
Zurück zum Zitat Liang CC, Lee TH, Chang SD. Effects of sex hormones on cell proliferation and apoptosis in the urinary bladder muscle of ovariectomized rat. Taiwan J Obstet Gynecol. 2013;52(3):335–40.CrossRefPubMed Liang CC, Lee TH, Chang SD. Effects of sex hormones on cell proliferation and apoptosis in the urinary bladder muscle of ovariectomized rat. Taiwan J Obstet Gynecol. 2013;52(3):335–40.CrossRefPubMed
9.
Zurück zum Zitat Robinson D, Toozs-Hobson P, Cardozo L. The effect of hormones on the lower urinary tract. Menopause Int. 2013;19(4):155–62.PubMed Robinson D, Toozs-Hobson P, Cardozo L. The effect of hormones on the lower urinary tract. Menopause Int. 2013;19(4):155–62.PubMed
10.
Zurück zum Zitat Elliott RA, Castleden CM. Effect of progestogens and oestrogens on the contractile response of rat detrusor muscle to electrical field stimulation. Clin Sci (Lond). 1994;87(3):337–42.CrossRef Elliott RA, Castleden CM. Effect of progestogens and oestrogens on the contractile response of rat detrusor muscle to electrical field stimulation. Clin Sci (Lond). 1994;87(3):337–42.CrossRef
11.
Zurück zum Zitat Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab. 2005;90(7):3847–53.CrossRefPubMed Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab. 2005;90(7):3847–53.CrossRefPubMed
12.
Zurück zum Zitat Zumoff B, Strain GW, Miller LK, Rosner W. Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab. 1995;80(4):1429–30.PubMed Zumoff B, Strain GW, Miller LK, Rosner W. Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab. 1995;80(4):1429–30.PubMed
13.
Zurück zum Zitat Glaser R, Kalantaridou S, Dimitrakakis C. Testosterone implants in women: pharmacological dosing for a physiologic effect. Maturitas. 2013;74(2):179–84.CrossRefPubMed Glaser R, Kalantaridou S, Dimitrakakis C. Testosterone implants in women: pharmacological dosing for a physiologic effect. Maturitas. 2013;74(2):179–84.CrossRefPubMed
14.•
Zurück zum Zitat Kwon JK, Kim JH, Choi H, et al. Voiding characteristics and related hormonal changes in peri-menopausal and post-menopausal women: a preliminary study. Maturitas. 2014;79(3):311–5. This study examined which hormones contributed to LUTS and sought to determine if changes in hormone levels during the menopausal transition significantly affected LUTS using standardized voiding symptom questionnaires. Their results suggested frequency can potentially worsen in the perimenopausal period, and SUI is more prevalent in the postmenopausal period; serum testosterone levels in women undergoing the menopausal transition negatively correlated with LUTS. CrossRefPubMed Kwon JK, Kim JH, Choi H, et al. Voiding characteristics and related hormonal changes in peri-menopausal and post-menopausal women: a preliminary study. Maturitas. 2014;79(3):311–5. This study examined which hormones contributed to LUTS and sought to determine if changes in hormone levels during the menopausal transition significantly affected LUTS using standardized voiding symptom questionnaires. Their results suggested frequency can potentially worsen in the perimenopausal period, and SUI is more prevalent in the postmenopausal period; serum testosterone levels in women undergoing the menopausal transition negatively correlated with LUTS. CrossRefPubMed
15.
Zurück zum Zitat Lin WY, Rehfuss A, Whitbeck C, et al. Effect of letrozole on urinary bladder function in the female rabbit. BJU Int. 2007;100(6):1391–5.CrossRefPubMed Lin WY, Rehfuss A, Whitbeck C, et al. Effect of letrozole on urinary bladder function in the female rabbit. BJU Int. 2007;100(6):1391–5.CrossRefPubMed
16.
Zurück zum Zitat Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int. 2011;108(7):1132–8.CrossRefPubMed Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int. 2011;108(7):1132–8.CrossRefPubMed
17.
Zurück zum Zitat Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–36.PubMed Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–36.PubMed
18.
Zurück zum Zitat Fantl JA. The lower urinary tract in women—effect of aging and menopause on continence. Exp Gerontol. 1994;29(3-4):417–22.CrossRefPubMed Fantl JA. The lower urinary tract in women—effect of aging and menopause on continence. Exp Gerontol. 1994;29(3-4):417–22.CrossRefPubMed
19.
Zurück zum Zitat Moehrer B, Hextall A, Jackson S. Oestrogens for urinary incontinence in women. Cochrane Database Syst Rev. 2003;2:CD001405.PubMed Moehrer B, Hextall A, Jackson S. Oestrogens for urinary incontinence in women. Cochrane Database Syst Rev. 2003;2:CD001405.PubMed
20.
Zurück zum Zitat Prentice RL, Chlebowski RT, Stefanick ML, et al. Conjugated equine estrogens and breast cancer risk in the Women’s Health Initiative clinical trial and observational study. American journal of epidemiology. 2008;167(12):1407–15.PubMedCentralCrossRefPubMed Prentice RL, Chlebowski RT, Stefanick ML, et al. Conjugated equine estrogens and breast cancer risk in the Women’s Health Initiative clinical trial and observational study. American journal of epidemiology. 2008;167(12):1407–15.PubMedCentralCrossRefPubMed
21.
Zurück zum Zitat Hendrix SL, Cochrane BB, Nygaard IE, et al. Effects of estrogen with and without progestin on urinary incontinence. Jama. 2005;293(8):935–48.CrossRefPubMed Hendrix SL, Cochrane BB, Nygaard IE, et al. Effects of estrogen with and without progestin on urinary incontinence. Jama. 2005;293(8):935–48.CrossRefPubMed
22.
Zurück zum Zitat Stothers L. Should hormone replacement therapy be used in postmenopausal women for voiding dysfunction? Can Urol Assoc J. 2009;3(2):150–2.PubMedCentralPubMed Stothers L. Should hormone replacement therapy be used in postmenopausal women for voiding dysfunction? Can Urol Assoc J. 2009;3(2):150–2.PubMedCentralPubMed
23.
Zurück zum Zitat Northington GM, de Vries HF, Bogner HR. Self-reported estrogen use and newly incident urinary incontinence among postmenopausal community-dwelling women. Menopause. 2012;19(3):290–5.PubMedCentralCrossRefPubMed Northington GM, de Vries HF, Bogner HR. Self-reported estrogen use and newly incident urinary incontinence among postmenopausal community-dwelling women. Menopause. 2012;19(3):290–5.PubMedCentralCrossRefPubMed
24.
Zurück zum Zitat Cody JD, Jacobs ML, Richardson K, Moehrer B, Hextall A. Oestrogen therapy for urinary incontinence in post-menopausal women. Cochrane Database Syst Rev. 2012;10:CD001405.PubMed Cody JD, Jacobs ML, Richardson K, Moehrer B, Hextall A. Oestrogen therapy for urinary incontinence in post-menopausal women. Cochrane Database Syst Rev. 2012;10:CD001405.PubMed
25.
Zurück zum Zitat Jackson S, James M, Abrams P. The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence. Bjog. 2002;109(3):339–44.CrossRefPubMed Jackson S, James M, Abrams P. The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence. Bjog. 2002;109(3):339–44.CrossRefPubMed
26.
Zurück zum Zitat Baglia ML, Gu K, Zhang X, et al. Soy isoflavone intake and bone mineral density in breast cancer survivors. Cancer Causes Control. 2015;26(4):571–80.CrossRefPubMed Baglia ML, Gu K, Zhang X, et al. Soy isoflavone intake and bone mineral density in breast cancer survivors. Cancer Causes Control. 2015;26(4):571–80.CrossRefPubMed
27.
Zurück zum Zitat Okada S, Kojima Y, Hamamoto S, Mizuno K, Sasaki S, Kohri K. Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with altered connexin-43 expression in the urinary bladder. BJU Int. 2009;103(10):1429–35.CrossRefPubMed Okada S, Kojima Y, Hamamoto S, Mizuno K, Sasaki S, Kohri K. Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with altered connexin-43 expression in the urinary bladder. BJU Int. 2009;103(10):1429–35.CrossRefPubMed
28.
Zurück zum Zitat Shenfeld OZ, McCammon KA, Blackmore PF, Ratz PH. Rapid effects of estrogen and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder. Urol Res. 1999;27(5):386–92.CrossRefPubMed Shenfeld OZ, McCammon KA, Blackmore PF, Ratz PH. Rapid effects of estrogen and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder. Urol Res. 1999;27(5):386–92.CrossRefPubMed
29.
Zurück zum Zitat Fantl JA, Wyman JF, Anderson RL, Matt DW, Bump RC. Postmenopausal urinary incontinence: comparison between non-estrogen-supplemented and estrogen-supplemented women. Obstet Gynecol. 1988;71(6 Pt 1):823–8.PubMed Fantl JA, Wyman JF, Anderson RL, Matt DW, Bump RC. Postmenopausal urinary incontinence: comparison between non-estrogen-supplemented and estrogen-supplemented women. Obstet Gynecol. 1988;71(6 Pt 1):823–8.PubMed
30.•
Zurück zum Zitat Cayan F, Tek M, Balli E, Oztuna S, Karazindiyanoglu S, Cayan S. The effect of testosterone alone and testosterone + estradiol therapy on bladder functions and smooth muscle/collagen content in surgically menopause induced rats. Maturitas. 2008;60(3-4):248–52. This study investigated the effect of testosterone alone and testosterone + estradiol therapy on bladder function and smooth muscle/collagen content in the surgically induced menopause rat model. It concluded bladder dysfunction is related to estrogen and androgen deficiency, and combination therapy may improve bladder functions and histology much better than estrogen therapy alone.CrossRefPubMed Cayan F, Tek M, Balli E, Oztuna S, Karazindiyanoglu S, Cayan S. The effect of testosterone alone and testosterone + estradiol therapy on bladder functions and smooth muscle/collagen content in surgically menopause induced rats. Maturitas. 2008;60(3-4):248–52. This study investigated the effect of testosterone alone and testosterone + estradiol therapy on bladder function and smooth muscle/collagen content in the surgically induced menopause rat model. It concluded bladder dysfunction is related to estrogen and androgen deficiency, and combination therapy may improve bladder functions and histology much better than estrogen therapy alone.CrossRefPubMed
31.
Zurück zum Zitat Kim NN, Min K, Pessina MA, Munarriz R, Goldstein I, Traish AM. Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility. International journal of impotence research. 2004;16(1):43–50.CrossRefPubMed Kim NN, Min K, Pessina MA, Munarriz R, Goldstein I, Traish AM. Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility. International journal of impotence research. 2004;16(1):43–50.CrossRefPubMed
32.
Zurück zum Zitat Casson PR, Elkind-Hirsch KE, Buster JE, Hornsby PJ, Carson SA, Snabes MC. Effect of postmenopausal estrogen replacement on circulating androgens. Obstet Gynecol. 1997;90(6):995–8.CrossRefPubMed Casson PR, Elkind-Hirsch KE, Buster JE, Hornsby PJ, Carson SA, Snabes MC. Effect of postmenopausal estrogen replacement on circulating androgens. Obstet Gynecol. 1997;90(6):995–8.CrossRefPubMed
33.
Zurück zum Zitat Nelken RS, Ozel BZ, Leegant AR, Felix JC, Mishell Jr DR. Randomized trial of estradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder. Menopause. 2011;18(9):962–6.CrossRefPubMed Nelken RS, Ozel BZ, Leegant AR, Felix JC, Mishell Jr DR. Randomized trial of estradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder. Menopause. 2011;18(9):962–6.CrossRefPubMed
34.
Zurück zum Zitat Serati M, Salvatore S, Uccella S, Cardozo L, Bolis P. Is there a synergistic effect of topical oestrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity? Eur Urol. 2009;55(3):713–9.CrossRefPubMed Serati M, Salvatore S, Uccella S, Cardozo L, Bolis P. Is there a synergistic effect of topical oestrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity? Eur Urol. 2009;55(3):713–9.CrossRefPubMed
35.
Zurück zum Zitat Yarnell JW, Voyle GJ, Sweetnam PM, Milbank J, Richards CJ, Stephenson TP. Factors associated with urinary incontinence in women. J Epidemiol Community Health. 1982;36(1):58–63.PubMedCentralCrossRefPubMed Yarnell JW, Voyle GJ, Sweetnam PM, Milbank J, Richards CJ, Stephenson TP. Factors associated with urinary incontinence in women. J Epidemiol Community Health. 1982;36(1):58–63.PubMedCentralCrossRefPubMed
36.
Zurück zum Zitat Mishra GD, Cardozo L, Kuh D. Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort. BJU Int. 2010;106(8):1170–5.PubMedCentralCrossRefPubMed Mishra GD, Cardozo L, Kuh D. Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort. BJU Int. 2010;106(8):1170–5.PubMedCentralCrossRefPubMed
37.
Zurück zum Zitat Jackson S, Shepherd A, Brookes S, Abrams P. The effect of oestrogen supplementation on post-menopausal urinary stress incontinence: a double-blind placebo-controlled trial. Br J Obstet Gynaecol. 1999;106(7):711–8.CrossRefPubMed Jackson S, Shepherd A, Brookes S, Abrams P. The effect of oestrogen supplementation on post-menopausal urinary stress incontinence: a double-blind placebo-controlled trial. Br J Obstet Gynaecol. 1999;106(7):711–8.CrossRefPubMed
38.
Zurück zum Zitat Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. Jama. 2002;288(3):321–33.CrossRefPubMed Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. Jama. 2002;288(3):321–33.CrossRefPubMed
39.•
Zurück zum Zitat Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. Jama. 2013;310(13):1353–68. This study was a continuation of the Women’s Health Initiative, with cumulative 13 years follow-up after enrollment. The increased risk of urinary incontinence seen in women on systemic conjugated equine estrogens with or without medroxyprogesterone acetate during the initial WHI persisted at most recent follow-up, reinforcing that systemic hormones should not be used for preventing incontinence among other chronic diseases in postmenopausal women.CrossRefPubMed Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. Jama. 2013;310(13):1353–68. This study was a continuation of the Women’s Health Initiative, with cumulative 13 years follow-up after enrollment. The increased risk of urinary incontinence seen in women on systemic conjugated equine estrogens with or without medroxyprogesterone acetate during the initial WHI persisted at most recent follow-up, reinforcing that systemic hormones should not be used for preventing incontinence among other chronic diseases in postmenopausal women.CrossRefPubMed
40.
Zurück zum Zitat Townsend MK, Curhan GC, Resnick NM, Grodstein F. Postmenopausal hormone therapy and incident urinary incontinence in middle-aged women. Am J Obstet Gynecol. 2009;200(1):86. e81-85.PubMedCentralPubMed Townsend MK, Curhan GC, Resnick NM, Grodstein F. Postmenopausal hormone therapy and incident urinary incontinence in middle-aged women. Am J Obstet Gynecol. 2009;200(1):86. e81-85.PubMedCentralPubMed
41.
Zurück zum Zitat Liapis A, Bakas P, Georgantopoulou C, Creatsas G. The use of oestradiol therapy in postmenopausal women after TVT-O anti-incontinence surgery. Maturitas. 2010;66(1):101–6.CrossRefPubMed Liapis A, Bakas P, Georgantopoulou C, Creatsas G. The use of oestradiol therapy in postmenopausal women after TVT-O anti-incontinence surgery. Maturitas. 2010;66(1):101–6.CrossRefPubMed
42.
Zurück zum Zitat Tinelli A, Malvasi A, D'Anna L, Tinelli R, Perrone A, Tinelli FG. Presurgical promestriene therapy in postmenopausal women with stress urinary incontinence. Gynecol Endocrinol. 2007;23(8):445–50.CrossRefPubMed Tinelli A, Malvasi A, D'Anna L, Tinelli R, Perrone A, Tinelli FG. Presurgical promestriene therapy in postmenopausal women with stress urinary incontinence. Gynecol Endocrinol. 2007;23(8):445–50.CrossRefPubMed
43.
Zurück zum Zitat Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. A urodynamic and clinical evaluation. Urol Int. 1984;39(4):211–6.CrossRefPubMed Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. A urodynamic and clinical evaluation. Urol Int. 1984;39(4):211–6.CrossRefPubMed
44.
Zurück zum Zitat Kobata SA, Girão MJ, Baracat EC, et al. Estrogen therapy influence on periurethral vessels in postmenopausal incontinent women using Dopplervelocimetry analysis. Maturitas. 2008;61(3):243–7.CrossRefPubMed Kobata SA, Girão MJ, Baracat EC, et al. Estrogen therapy influence on periurethral vessels in postmenopausal incontinent women using Dopplervelocimetry analysis. Maturitas. 2008;61(3):243–7.CrossRefPubMed
45.
Zurück zum Zitat Long CY, Liu CM, Hsu SC, Wu CH, Wang CL, Tsai EM. A randomized comparative study of the effects of oral and topical estrogen therapy on the vaginal vascularization and sexual function in hysterectomized postmenopausal women. Menopause. 2006;13(5):737–43.CrossRefPubMed Long CY, Liu CM, Hsu SC, Wu CH, Wang CL, Tsai EM. A randomized comparative study of the effects of oral and topical estrogen therapy on the vaginal vascularization and sexual function in hysterectomized postmenopausal women. Menopause. 2006;13(5):737–43.CrossRefPubMed
46.
Zurück zum Zitat Luthje P, Brauner H, Ramos NL, et al. Estrogen supports urothelial defense mechanisms. Sci Transl Med. 2003;5(190):190ra180. Luthje P, Brauner H, Ramos NL, et al. Estrogen supports urothelial defense mechanisms. Sci Transl Med. 2003;5(190):190ra180.
47.
Zurück zum Zitat Hannan TJ, Hooton TM, Hultgren SJ. Estrogen and recurrent UTI: what are the facts? Sci Transl Med. 2013;5(190):190fs123.CrossRef Hannan TJ, Hooton TM, Hultgren SJ. Estrogen and recurrent UTI: what are the facts? Sci Transl Med. 2013;5(190):190fs123.CrossRef
48.
Zurück zum Zitat Eriksen B. A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women. Am J Obstet Gynecol. 1999;180(5):1072–9.CrossRefPubMed Eriksen B. A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women. Am J Obstet Gynecol. 1999;180(5):1072–9.CrossRefPubMed
49.
Zurück zum Zitat Beerepoot MA, Geerlings SE, van Haarst EP, van Charante NM, ter Riet G. Nonantibiotic prophylaxis for recurrent urinary tract infections: a systematic review and meta-analysis of randomized controlled trials. J Urol Dec. 2013;190(6):1981–9.CrossRef Beerepoot MA, Geerlings SE, van Haarst EP, van Charante NM, ter Riet G. Nonantibiotic prophylaxis for recurrent urinary tract infections: a systematic review and meta-analysis of randomized controlled trials. J Urol Dec. 2013;190(6):1981–9.CrossRef
50.
Zurück zum Zitat Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med. 1993;329(11):753–6.CrossRefPubMed Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med. 1993;329(11):753–6.CrossRefPubMed
51.
Zurück zum Zitat Cardozo L, Lose G, McClish D, Versi E, de Koning GH. A systematic review of estrogens for recurrent urinary tract infections: third report of the hormones and urogenital therapy (HUT) committee. Int Urogynecol J Pelvic Floor Dysfunct. 2001;12(1):15–20.CrossRefPubMed Cardozo L, Lose G, McClish D, Versi E, de Koning GH. A systematic review of estrogens for recurrent urinary tract infections: third report of the hormones and urogenital therapy (HUT) committee. Int Urogynecol J Pelvic Floor Dysfunct. 2001;12(1):15–20.CrossRefPubMed
52.
Zurück zum Zitat Portman D, Palacios S, Nappi RE, Mueck AO. Ospemifene, a non-oestrogen selective oestrogen receptor modulator for the treatment of vaginal dryness associated with postmenopausal vulvar and vaginal atrophy: a randomised, placebo-controlled, phase III trial. Maturitas. 2014;78(2):91–8.CrossRefPubMed Portman D, Palacios S, Nappi RE, Mueck AO. Ospemifene, a non-oestrogen selective oestrogen receptor modulator for the treatment of vaginal dryness associated with postmenopausal vulvar and vaginal atrophy: a randomised, placebo-controlled, phase III trial. Maturitas. 2014;78(2):91–8.CrossRefPubMed
53.
Zurück zum Zitat Nappi RE, Panay N, Bruyniks N, Castelo-Branco C, De Villiers TJ, Simon JA. The clinical relevance of the effect of ospemifene on symptoms of vulvar and vaginal atrophy. Climacteric. 2015;18(2):233–40.PubMedCentralCrossRefPubMed Nappi RE, Panay N, Bruyniks N, Castelo-Branco C, De Villiers TJ, Simon JA. The clinical relevance of the effect of ospemifene on symptoms of vulvar and vaginal atrophy. Climacteric. 2015;18(2):233–40.PubMedCentralCrossRefPubMed
54.
Zurück zum Zitat Simon J, Portman D, Mabey RG, Group OS. Long-term safety of ospemifene (52-week extension) in the treatment of vulvar and vaginal atrophy in hysterectomized postmenopausal women. Maturitas. 2014;77(3):274–81.CrossRefPubMed Simon J, Portman D, Mabey RG, Group OS. Long-term safety of ospemifene (52-week extension) in the treatment of vulvar and vaginal atrophy in hysterectomized postmenopausal women. Maturitas. 2014;77(3):274–81.CrossRefPubMed
55.•
Zurück zum Zitat Archer DF, Carr BR, Pinkerton JV, Taylor HS, Constantine GD. Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. Menopause. 2015;22(7):786–96. This manuscript provides a comprehensive overview of the mechanism of action that ospemifene has on the genitourinary tract in both animal studies and clinical data. This agent appears to have no significant adverse effect on urinary symptoms in a 52-week study, which may offer an alternative use of hormone manipulation without a direct agonist effect.PubMedCentralCrossRefPubMed Archer DF, Carr BR, Pinkerton JV, Taylor HS, Constantine GD. Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. Menopause. 2015;22(7):786–96. This manuscript provides a comprehensive overview of the mechanism of action that ospemifene has on the genitourinary tract in both animal studies and clinical data. This agent appears to have no significant adverse effect on urinary symptoms in a 52-week study, which may offer an alternative use of hormone manipulation without a direct agonist effect.PubMedCentralCrossRefPubMed
56.
Zurück zum Zitat Goldstein SR, Nanavati N. Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study. Am J Obstet Gynecol. 2002;187(3):521–7.CrossRefPubMed Goldstein SR, Nanavati N. Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study. Am J Obstet Gynecol. 2002;187(3):521–7.CrossRefPubMed
57.
Zurück zum Zitat Waetjen LE, Brown JS, Modelska K, et al. Effect of raloxifene on urinary incontinence: a randomized controlled trial. Obstet Gynecol. 2004;103(2):261–6.CrossRefPubMed Waetjen LE, Brown JS, Modelska K, et al. Effect of raloxifene on urinary incontinence: a randomized controlled trial. Obstet Gynecol. 2004;103(2):261–6.CrossRefPubMed
58.
Zurück zum Zitat Goldstein SR, Neven P, Cummings S, et al. Postmenopausal Evaluation and Risk Reduction With Lasofoxifene (PEARL) trial: 5-year gynecological outcomes. Menopause. 2011;18(1):17–22.CrossRefPubMed Goldstein SR, Neven P, Cummings S, et al. Postmenopausal Evaluation and Risk Reduction With Lasofoxifene (PEARL) trial: 5-year gynecological outcomes. Menopause. 2011;18(1):17–22.CrossRefPubMed
59.
Zurück zum Zitat Fishman JR, Flatt MA, Settersten RA. Bioidentical hormones, menopausal women, and the lure of the “natural” in U.S. anti-aging medicine. Soc Sci Med. 2015;132:79–87.CrossRefPubMed Fishman JR, Flatt MA, Settersten RA. Bioidentical hormones, menopausal women, and the lure of the “natural” in U.S. anti-aging medicine. Soc Sci Med. 2015;132:79–87.CrossRefPubMed
60.
Zurück zum Zitat Ayton RA, Darling GM, Murkies AL, et al. A comparative study of safety and efficacy of continuous low dose oestradiol released from a vaginal ring compared with conjugated equine oestrogen vaginal cream in the treatment of postmenopausal urogenital atrophy. Br J Obstet Gynaecol. 1996;103(4):351–8.CrossRefPubMed Ayton RA, Darling GM, Murkies AL, et al. A comparative study of safety and efficacy of continuous low dose oestradiol released from a vaginal ring compared with conjugated equine oestrogen vaginal cream in the treatment of postmenopausal urogenital atrophy. Br J Obstet Gynaecol. 1996;103(4):351–8.CrossRefPubMed
61.
Zurück zum Zitat Barentsen R, van de Weijer PH, Schram JH. Continuous low dose estradiol released from a vaginal ring versus estriol vaginal cream for urogenital atrophy. Eur J Obstet Gynecol Reprod Biol. 1997;71(1):73–80.CrossRefPubMed Barentsen R, van de Weijer PH, Schram JH. Continuous low dose estradiol released from a vaginal ring versus estriol vaginal cream for urogenital atrophy. Eur J Obstet Gynecol Reprod Biol. 1997;71(1):73–80.CrossRefPubMed
62.
Zurück zum Zitat Suckling J, Lethaby A, Kennedy R. Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database Syst Rev. 2006;4:CD001500.PubMed Suckling J, Lethaby A, Kennedy R. Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database Syst Rev. 2006;4:CD001500.PubMed
63.
Zurück zum Zitat Shim SH, Lee SJ, Kim SN. Effects of hormone replacement therapy on the rate of recurrence in endometrial cancer survivors: a meta-analysis. Eur J Cancer. 2014;50(9):1628–37.CrossRefPubMed Shim SH, Lee SJ, Kim SN. Effects of hormone replacement therapy on the rate of recurrence in endometrial cancer survivors: a meta-analysis. Eur J Cancer. 2014;50(9):1628–37.CrossRefPubMed
64.
Zurück zum Zitat Vaccaro CM, Mutema GK, Fellner AN, et al. Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial. Female Pelvic Med Reconstr Surg. 2013;19(1):34–9.CrossRefPubMed Vaccaro CM, Mutema GK, Fellner AN, et al. Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial. Female Pelvic Med Reconstr Surg. 2013;19(1):34–9.CrossRefPubMed
65.
Zurück zum Zitat Rahn DD, Good MM, Roshanravan SM, et al. Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial. J Clin Endocrinol Metab. 2014;99(10):3728–36.PubMedCentralCrossRefPubMed Rahn DD, Good MM, Roshanravan SM, et al. Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial. J Clin Endocrinol Metab. 2014;99(10):3728–36.PubMedCentralCrossRefPubMed
66.
Zurück zum Zitat Rahn DD, Good MM, Roshanravan SM, et al. Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial. The Journal of clinical endocrinology and metabolism. 2014;99(10):3728–36.PubMedCentralCrossRefPubMed Rahn DD, Good MM, Roshanravan SM, et al. Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial. The Journal of clinical endocrinology and metabolism. 2014;99(10):3728–36.PubMedCentralCrossRefPubMed
Metadaten
Titel
Effect of Hormonal Changes on Voiding in the Elderly Woman
verfasst von
Esther Han
Priyanka Gupta
Jason P. Gilleran
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports / Ausgabe 4/2015
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-015-0339-y

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