01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer
- Zeitschrift:
- BMC Cancer > Ausgabe 1/2017
Electronic supplementary material
Background
Results
Gene expression and analysis
Strain
|
UP
|
DOWN
|
TOTAL
|
---|---|---|---|
WT 25 weeks
|
7
|
3
|
10
|
WT 47 weeks
|
189
|
87
|
276
|
Myd88
−/− 25 weeks
|
1031
|
958
|
1989
|
Myd88
−/− 47 weeks
|
1140
|
1022
|
2162
|
Analysis of differentially expressed genes
Symbol
|
Gene Name
|
LogFC
|
Adj. P.Val
|
---|---|---|---|
Chil4
|
chitinase-like 4
|
5.77
|
4.05E-04
|
Bpifb1
|
BPI fold containing family B, member 1
|
4.90
|
1.97E-04
|
Cd74
|
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
|
4.28
|
4.93E-08
|
H2-Ab1
|
histocompatibility 2, class II antigen A, beta 1
|
4.09
|
2.35E-07
|
Ido1
|
indoleamine 2,3-dioxygenase 1
|
3.88
|
1.39E-04
|
H2-DMa
|
histocompatibility 2, class II, locus DMa
|
3.34
|
1.29E-05
|
H2-DMb2
|
histocompatibility 2, class II, locus Mb2
|
3.33
|
2.22E-06
|
Igtp
|
interferon gamma induced GTPase
|
3.29
|
1.54E-04
|
H2-Eb1
|
histocompatibility 2, class II antigen E beta
|
3.28
|
2.51E-06
|
Gbp2
|
guanylate binding protein 2
|
3.27
|
3.49E-05
|
Sftpd
|
surfactant associated protein D
|
3.26
|
3.73E-07
|
Psmb8
|
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
|
2.92
|
3.46E-06
|
H2-K2
|
histocompatibility 2, K region locus 2
|
2.78
|
2.64E-07
|
H2-K1
|
histocompatibility 2, K1, K region
|
2.64
|
1.04E-06
|
B2m
|
beta-2 microglobulin
|
2.59
|
3.46E-06
|
Pkp4
|
plakophilin 4
|
2.54
|
2.04E-06
|
H2-DMb1
|
histocompatibility 2, class II, locus Mb1
|
2.52
|
3.46E-06
|
Ubd
|
ubiquitin D
|
2.51
|
2.90E-04
|
H2-Aa
|
histocompatibility 2, class II antigen A, alpha
|
2.47
|
2.15E-05
|
Irgm2
|
immunity-related GTPase family M member 2
|
2.42
|
9.04E-05
|
H2-Q7
|
histocompatibility 2, Q region locus 7
|
2.32
|
2.22E-06
|
Cxcl9
|
chemokine (C-X-C motif) ligand 9
|
2.30
|
6.23E-05
|
Irf1
|
interferon regulatory factor 1
|
2.23
|
7.54E-05
|
Serpina3g
|
serine (or cysteine) peptidase inhibitor, clade A, member 3G
|
2.22
|
5.85E-06
|
H2-M2
|
histocompatibility 2, M region locus 2
|
2.21
|
5.85E-06
|
Casp1
|
caspase 1
|
2.17
|
1.86E-04
|
H2-D1
|
histocompatibility 2, D region locus 1
|
2.17
|
1.07E-06
|
Ear2
|
eosinophil-associated, ribonuclease A family, member 2
|
2.16
|
6.91E-04
|
H2-T23
|
histocompatibility 2, T region locus 23
|
2.07
|
5.85E-06
|
Psmb9
|
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
|
2.05
|
1.54E-04
|
Psmb10
|
proteasome (prosome, macropain) subunit, beta type 10
|
2.03
|
5.50E-05
|
Sgk1
|
serum/glucocorticoid regulated kinase 1
|
−2.01
|
3.48E-04
|
Apoa4
|
apolipoprotein A-IV
|
−2.31
|
2.33E-05
|
Ttr
|
transthyretin
|
−2.37
|
2.15E-05
|
Fabp3
|
fatty acid binding protein 3, muscle and heart
|
−2.37
|
1.61E-04
|
Muc5ac
|
mucin 5, subtypes A and C, tracheobronchial/gastric
|
−2.41
|
7.14E-04
|
Smim24
|
small integral membrane protein 24
|
−2.61
|
3.46E-06
|
Lpl
|
lipoprotein lipase
|
−2.75
|
8.29E-05
|
Pdia2
|
protein disulfide isomerase associated 2
|
−3.08
|
3.10E-05
|
Pnliprp1
|
pancreatic lipase related protein 1
|
−3.18
|
5.76E-04
|
Gm5771
|
predicted gene 5771
|
−3.36
|
3.53E-04
|
Hamp2
|
hepcidin antimicrobial peptide 2
|
−3.43
|
1.59E-04
|
Pnliprp2
|
pancreatic lipase-related protein 2
|
−3.44
|
7.47E-04
|
Rnase1
|
ribonuclease, RNase A family, 1 (pancreatic)
|
−3.78
|
5.55E-04
|
Try5
|
trypsin 5
|
−4.17
|
7.45E-04
|
Gm5409
|
predicted pseudogene 5409
|
−4.44
|
4.89E-05
|
Try4
|
trypsin 4
|
−4.87
|
4.39E-05
|
Try10
|
trypsin 10
|
−5.08
|
2.69E-06
|
Amy2a5
|
amylase 2a5
|
−6.44
|
2.22E-06
|
Chia1
|
chitinase, acidic 1
|
−6.68
|
8.93E-05
|
Gene Symbol
|
Gene Name
|
LogFC
|
Adj. P.Val
|
---|---|---|---|
Chil4
|
chitinase-like 4
|
4.97
|
1.24E-03
|
Cd74
|
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
|
4.18
|
7.41E-08
|
Bpifb1
|
BPI fold containing family B, member 1
|
4.02
|
6.43E-04
|
H2-Ab1
|
histocompatibility 2, class II antigen A, beta 1
|
3.96
|
4.14E-07
|
Ido1
|
indoleamine 2,3-dioxygenase 1
|
3.78
|
1.44E-04
|
Igtp
|
interferon gamma induced GTPase
|
3.29
|
1.25E-04
|
Sftpd
|
surfactant associated protein D
|
3.24
|
4.86E-07
|
H2-DMb2
|
histocompatibility 2, class II, locus Mb2
|
3.20
|
4.43E-06
|
Psmb8
|
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
|
3.20
|
1.71E-06
|
Gbp2
|
guanylate binding protein 2
|
3.15
|
4.53E-05
|
H2-DMa
|
histocompatibility 2, class II, locus DMa
|
3.13
|
2.17E-05
|
H2-Eb1
|
histocompatibility 2, class II antigen E beta
|
3.05
|
6.39E-06
|
Ubd
|
ubiquitin D
|
2.85
|
8.22E-05
|
B2m
|
beta-2 microglobulin
|
2.81
|
4.14E-07
|
H2-K2
|
histocompatibility 2, K region locus 2
|
2.58
|
7.37E-07
|
H2-Aa
|
histocompatibility 2, class II antigen A, alpha
|
2.56
|
1.39E-05
|
Irgm2
|
immunity-related GTPase family M member 2
|
2.53
|
5.62E-05
|
H2-DMb1
|
histocompatibility 2, class II, locus Mb1
|
2.47
|
5.72E-06
|
H2-K1
|
histocompatibility 2, K1, K region
|
2.40
|
3.89E-06
|
Serpina3g
|
serine (or cysteine) peptidase inhibitor, clade A, member 3G
|
2.30
|
4.90E-06
|
Psmb9
|
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
|
2.30
|
4.92E-05
|
Psmb10
|
proteasome (prosome, macropain) subunit, beta type 10
|
2.29
|
1.49E-05
|
Pigr
|
polymeric immunoglobulin receptor
|
2.29
|
2.37E-05
|
Oasl2
|
2′-5′ oligoadenylate synthetase-like 2
|
2.24
|
6.52E-04
|
H2-Q7
|
histocompatibility 2, Q region locus 7
|
2.22
|
4.90E-06
|
Casp1
|
caspase 1
|
2.20
|
1.33E-04
|
Irf1
|
interferon regulatory factor 1
|
2.17
|
8.33E-05
|
C3
|
complement component 3
|
2.15
|
4.52E-05
|
Cxcl9
|
chemokine (C-X-C motif) ligand 9
|
2.14
|
1.04E-04
|
Pkp4
|
plakophilin 4
|
2.11
|
1.28E-05
|
Rnf213
|
ring finger protein 213
|
2.08
|
1.59E-04
|
H2-D1
|
histocompatibility 2, D region locus 1
|
2.04
|
2.78E-06
|
Ear2
|
eosinophil-associated, ribonuclease A family, member 2
|
2.04
|
9.57E-04
|
Sst
|
somatostatin
|
−2.01
|
1.25E-04
|
Smim24
|
small integral membrane protein 24
|
−2.11
|
3.12E-05
|
Muc5ac
|
mucin 5, subtypes A and C, tracheobronchial/gastric
|
−2.23
|
1.14E-03
|
Lpl
|
lipoprotein lipase
|
−2.32
|
3.50E-04
|
Sgk1
|
serum/glucocorticoid regulated kinase 1
|
−2.33
|
8.22E-05
|
Ckb
|
creatine kinase, brain
|
−2.35
|
1.02E-04
|
Gif
|
gastric intrinsic factor
|
−2.36
|
3.50E-04
|
Cox7a1
|
cytochrome c oxidase subunit VIIa 1
|
−2.49
|
1.06E-04
|
Ttr
|
transthyretin
|
−2.57
|
9.85E-06
|
Dpcr1
|
diffuse panbronchiolitis critical region 1 (human)
|
−2.57
|
1.05E-03
|
Fabp3
|
fatty acid binding protein 3, muscle and heart
|
−2.61
|
6.23E-05
|
Atp4a
|
ATPase, H+/K+ exchanging, gastric, alpha polypeptide
|
−2.95
|
6.99E-04
|
Apoa1
|
apolipoprotein A-I
|
−3.13
|
1.23E-03
|
Hamp2
|
hepcidin antimicrobial peptide 2
|
−3.45
|
1.25E-04
|
Pdia2
|
protein disulfide isomerase associated 2
|
−3.57
|
7.21E-06
|
Amy2a5
|
amylase 2a5
|
−4.09
|
1.74E-04
|
Chia1
|
chitinase, acidic 1
|
−5.25
|
6.66E-04
|