Skip to main content
Erschienen in: European Archives of Oto-Rhino-Laryngology 5/2020

12.02.2020 | Head and Neck

Effect of prophylactic central neck dissection on the surgical outcomes in papillary thyroid cancer: experience in a single center

verfasst von: Dilek Yazıcı, Bülent Çolakoğlu, Burçin Sağlam, Havva Sezer, Yersu Kapran, Özlem Aydın, Mehmet Onur Demirkol, Faruk Alagöl, Tarık Terzioğlu

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Morbidity due to papillary thyroid carcinoma (PTC) is increased mostly due to lymph node (LN) metastases, which lead to reoperations and complications associated with these operations. The aim is to compare the outcomes of PTC having total thyroidectomy and prophylactic central lymph node dissection (TT + PCND) with patients having total thyroidectomy (TT) alone.

Methods

This study is a retrospective cohort analysis of 358 PTC patients that were operated by a single surgeon in a single center. Data about the patients were extracted from the medical records.

Results

Of the patient cohort, 258 patients had TT + PCND (42.5 ± 11.3 years) and 100 patients (41.2 ± 11.9 years) had only TT. Total number of LN extracted in the TT + PCND group was 8.1 ± 6.9. The mean number of metastatic LN were 2.2 ± 1.9. Percentage of patients that had RAI were less in the TT + PCND group compared to the TT group. Seven patients (2.7%) in the TT + PCND group and 19 (19.0%) in TT group had recurrent disease (p < 0.0001). Of the complications, only transient hypoparathyroidism was increased in TT + PCND group compared to TT group (26.7% vs 10%, p < 0.0001).

Conclusion

TT + PCND performed by an experienced surgeon seems to decrease the number of LN recurrences, and the need for reoperations.
Literatur
3.
Zurück zum Zitat Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid 26(1):1–133. https://doi.org/10.1089/thy.2015.0020 CrossRefPubMedPubMedCentral Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid 26(1):1–133. https://​doi.​org/​10.​1089/​thy.​2015.​0020 CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Conzo G, Tartaglia E, Avenia N, Calo PG, de Bellis A, Esposito K, Gambardella C, Iorio S, Pasquali D, Santini L, Sinisi MA, Sinisi AA, Testini M, Polistena A, Bellastella G (2016) Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends. World J Surg Oncol 14:149. https://doi.org/10.1186/s12957-016-0879-4 CrossRefPubMedPubMedCentral Conzo G, Tartaglia E, Avenia N, Calo PG, de Bellis A, Esposito K, Gambardella C, Iorio S, Pasquali D, Santini L, Sinisi MA, Sinisi AA, Testini M, Polistena A, Bellastella G (2016) Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends. World J Surg Oncol 14:149. https://​doi.​org/​10.​1186/​s12957-016-0879-4 CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Viola D, Materazzi G, Valerio L, Molinaro E, Agate L, Faviana P, Seccia V, Sensi E, Romei C, Piaggi P, Torregrossa L, Sellari-Franceschini S, Basolo F, Vitti P, Elisei R, Miccoli P (2015) Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled single institution study. J Clin Endocrinol Metab 100(4):1316–1324. https://doi.org/10.1210/jc.2014-3825 CrossRefPubMed Viola D, Materazzi G, Valerio L, Molinaro E, Agate L, Faviana P, Seccia V, Sensi E, Romei C, Piaggi P, Torregrossa L, Sellari-Franceschini S, Basolo F, Vitti P, Elisei R, Miccoli P (2015) Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled single institution study. J Clin Endocrinol Metab 100(4):1316–1324. https://​doi.​org/​10.​1210/​jc.​2014-3825 CrossRefPubMed
11.
Zurück zum Zitat Mamelle E, Borget I, Leboulleux S, Mirghani H, Suarez C, Pellitteri PK, Shaha AR, Hamoir M, Robbins KT, Khafif A, Rodrigo JP, Silver CE, Rinaldo A, Ferlito A, Hartl DM (2015) Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma: a review. Eur Arch Oto-rhino-laryngol 272(7):1577–1586. https://doi.org/10.1007/s00405-014-3104-5 CrossRef Mamelle E, Borget I, Leboulleux S, Mirghani H, Suarez C, Pellitteri PK, Shaha AR, Hamoir M, Robbins KT, Khafif A, Rodrigo JP, Silver CE, Rinaldo A, Ferlito A, Hartl DM (2015) Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma: a review. Eur Arch Oto-rhino-laryngol 272(7):1577–1586. https://​doi.​org/​10.​1007/​s00405-014-3104-5 CrossRef
12.
Zurück zum Zitat Zhang LY, Liu ZW, Liu YW, Gao WS, Zheng CJ (2015) Risk factors for nodal metastasis in cN0 papillary thyroid microcarcinoma. Asian Pac J Cancer Prev 16(8):3361–3363CrossRefPubMed Zhang LY, Liu ZW, Liu YW, Gao WS, Zheng CJ (2015) Risk factors for nodal metastasis in cN0 papillary thyroid microcarcinoma. Asian Pac J Cancer Prev 16(8):3361–3363CrossRefPubMed
15.
Zurück zum Zitat Scheumann GF, Gimm O, Wegener G, Hundeshagen H, Dralle H (1994) Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer. World J Surg 18(4):559–567 (discussion 567–558) CrossRefPubMed Scheumann GF, Gimm O, Wegener G, Hundeshagen H, Dralle H (1994) Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer. World J Surg 18(4):559–567 (discussion 567–558) CrossRefPubMed
16.
Zurück zum Zitat Conzo G, Calo PG, Sinisi AA, De Bellis A, Pasquali D, Iorio S, Tartaglia E, Mauriello C, Gambardella C, Cavallo F, Medas F, Polistena A, Santini L, Avenia N (2014) Impact of prophylactic central compartment neck dissection on locoregional recurrence of differentiated thyroid cancer in clinically node-negative patients: a retrospective study of a large clinical series. Surgery 155(6):998–1005. https://doi.org/10.1016/j.surg.2014.02.010 CrossRefPubMed Conzo G, Calo PG, Sinisi AA, De Bellis A, Pasquali D, Iorio S, Tartaglia E, Mauriello C, Gambardella C, Cavallo F, Medas F, Polistena A, Santini L, Avenia N (2014) Impact of prophylactic central compartment neck dissection on locoregional recurrence of differentiated thyroid cancer in clinically node-negative patients: a retrospective study of a large clinical series. Surgery 155(6):998–1005. https://​doi.​org/​10.​1016/​j.​surg.​2014.​02.​010 CrossRefPubMed
17.
Zurück zum Zitat Gambardella C, Tartaglia E, Nunziata A, Izzo G, Siciliano G, Cavallo F, Mauriello C, Napolitano S, Thomas G, Testa D, Rossetti G, Sanguinetti A, Avenia N, Conzo G (2016) Clinical significance of prophylactic central compartment neck dissection in the treatment of clinically node-negative papillary thyroid cancer patients. World J Surg Oncol 14(1):247. https://doi.org/10.1186/s12957-016-1003-5 CrossRefPubMedPubMedCentral Gambardella C, Tartaglia E, Nunziata A, Izzo G, Siciliano G, Cavallo F, Mauriello C, Napolitano S, Thomas G, Testa D, Rossetti G, Sanguinetti A, Avenia N, Conzo G (2016) Clinical significance of prophylactic central compartment neck dissection in the treatment of clinically node-negative papillary thyroid cancer patients. World J Surg Oncol 14(1):247. https://​doi.​org/​10.​1186/​s12957-016-1003-5 CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Shen WT, Ogawa L, Ruan D, Suh I, Kebebew E, Duh QY, Clark OH (2010) Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperations. Arch Surg (Chicago, Ill: 1960) 145(3):272–275. https://doi.org/10.1001/archsurg.2010.9 CrossRef Shen WT, Ogawa L, Ruan D, Suh I, Kebebew E, Duh QY, Clark OH (2010) Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperations. Arch Surg (Chicago, Ill: 1960) 145(3):272–275. https://​doi.​org/​10.​1001/​archsurg.​2010.​9 CrossRef
24.
Zurück zum Zitat Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19(11):1167–1214. https://doi.org/10.1089/thy.2009.0110 CrossRefPubMed Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19(11):1167–1214. https://​doi.​org/​10.​1089/​thy.​2009.​0110 CrossRefPubMed
31.
Zurück zum Zitat Conzo G, Avenia N, Ansaldo GL, Calo P, De Palma M, Dobrinja C, Docimo G, Gambardella C, Grasso M, Lombardi CP, Pelizzo MR, Pezzolla A, Pezzullo L, Piccoli M, Rosato L, Siciliano G, Spiezia S, Tartaglia E, Tartaglia F, Testini M, Troncone G, Signoriello G (2017) Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series. Endocrine 55(2):530–538. https://doi.org/10.1007/s12020-016-0953-2 CrossRefPubMed Conzo G, Avenia N, Ansaldo GL, Calo P, De Palma M, Dobrinja C, Docimo G, Gambardella C, Grasso M, Lombardi CP, Pelizzo MR, Pezzolla A, Pezzullo L, Piccoli M, Rosato L, Siciliano G, Spiezia S, Tartaglia E, Tartaglia F, Testini M, Troncone G, Signoriello G (2017) Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series. Endocrine 55(2):530–538. https://​doi.​org/​10.​1007/​s12020-016-0953-2 CrossRefPubMed
36.
Zurück zum Zitat Korkmaz MH, Ocal B, Saylam G, Cakal E, Bayir O, Tutal E, Tatar EC (2017) The need of prophylactic central lymph node dissection is controversial in terms of postoperative thyroglobulin follow-up of patients with cN0 papillary thyroid cancer. Langenbeck's Arch Surg 402(2):235–242. https://doi.org/10.1007/s00423-017-1556-y CrossRef Korkmaz MH, Ocal B, Saylam G, Cakal E, Bayir O, Tutal E, Tatar EC (2017) The need of prophylactic central lymph node dissection is controversial in terms of postoperative thyroglobulin follow-up of patients with cN0 papillary thyroid cancer. Langenbeck's Arch Surg 402(2):235–242. https://​doi.​org/​10.​1007/​s00423-017-1556-y CrossRef
37.
Zurück zum Zitat Dobrinja C, Troian M, Cipolat Mis T, Rebez G, Bernardi S, Fabris B, Piscopello L, Makovac P, Di Gregorio F, de Manzini N (2017) Rationality in prophylactic central neck dissection in clinically node-negative (cN0) papillary thyroid carcinoma: is there anything more to say? A decade experience in a single-center. Int J Surg (Lond, Engl) 41(Suppl 1):S40–S47. https://doi.org/10.1016/j.ijsu.2017.01.113 CrossRef Dobrinja C, Troian M, Cipolat Mis T, Rebez G, Bernardi S, Fabris B, Piscopello L, Makovac P, Di Gregorio F, de Manzini N (2017) Rationality in prophylactic central neck dissection in clinically node-negative (cN0) papillary thyroid carcinoma: is there anything more to say? A decade experience in a single-center. Int J Surg (Lond, Engl) 41(Suppl 1):S40–S47. https://​doi.​org/​10.​1016/​j.​ijsu.​2017.​01.​113 CrossRef
42.
Zurück zum Zitat Ito Y, Kihara M, Kobayashi K, Miya A, Miyauchi A (2014) Permanent hypoparathyroidism after completion total thyroidectomy as a second surgery: how do we avoid it? Endocr J 61(4):403–408CrossRefPubMed Ito Y, Kihara M, Kobayashi K, Miya A, Miyauchi A (2014) Permanent hypoparathyroidism after completion total thyroidectomy as a second surgery: how do we avoid it? Endocr J 61(4):403–408CrossRefPubMed
43.
Zurück zum Zitat Livhits MJYM (2018) Patients with differentiated thyroid cancer who undergo reoperation for recurrence have increased mortality. Clin Thyroidol 30:361–363CrossRef Livhits MJYM (2018) Patients with differentiated thyroid cancer who undergo reoperation for recurrence have increased mortality. Clin Thyroidol 30:361–363CrossRef
44.
Zurück zum Zitat van Velsen EFS, Stegenga MT, van Kemenade FJ, Kam BLR, van Ginhoven TM, Visser WE, Peeters RP (2018) Comparing the prognostic value of the eighth edition of the American Joint Committee on Cancer/tumor node metastasis staging system between papillary and follicular thyroid cancer. Thyroid 28(8):976–981. https://doi.org/10.1089/thy.2018.0066 CrossRefPubMed van Velsen EFS, Stegenga MT, van Kemenade FJ, Kam BLR, van Ginhoven TM, Visser WE, Peeters RP (2018) Comparing the prognostic value of the eighth edition of the American Joint Committee on Cancer/tumor node metastasis staging system between papillary and follicular thyroid cancer. Thyroid 28(8):976–981. https://​doi.​org/​10.​1089/​thy.​2018.​0066 CrossRefPubMed
Metadaten
Titel
Effect of prophylactic central neck dissection on the surgical outcomes in papillary thyroid cancer: experience in a single center
verfasst von
Dilek Yazıcı
Bülent Çolakoğlu
Burçin Sağlam
Havva Sezer
Yersu Kapran
Özlem Aydın
Mehmet Onur Demirkol
Faruk Alagöl
Tarık Terzioğlu
Publikationsdatum
12.02.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2020
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-020-05830-1

Weitere Artikel der Ausgabe 5/2020

European Archives of Oto-Rhino-Laryngology 5/2020 Zur Ausgabe

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Eingreifen von Umstehenden rettet vor Erstickungstod

15.05.2024 Fremdkörperaspiration Nachrichten

Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

Real-World-Daten sprechen eher für Dupilumab als für Op.

14.05.2024 Rhinosinusitis Nachrichten

Zur Behandlung schwerer Formen der chronischen Rhinosinusitis mit Nasenpolypen (CRSwNP) stehen seit Kurzem verschiedene Behandlungsmethoden zur Verfügung, darunter Biologika, wie Dupilumab, und die endoskopische Sinuschirurgie (ESS). Beim Vergleich der beiden Therapieoptionen war Dupilumab leicht im Vorteil.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.