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01.09.2011 | Original Article—Alimentary Tract

Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans

verfasst von: Yuuichi Aizawa, Joe Morishita, Michiko Kano, Takayuki Mori, Shin-Ichi Izumi, Kenichiro Tsutsui, Toshio Iijima, Motoyori Kanazawa, Shin Fukudo

Erschienen in: Journal of Gastroenterology | Ausgabe 9/2011

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Abstract

Background

A previous brain imaging study demonstrated activation of the right dorsolateral prefrontal cortex (DLPFC) during visceral nociception, and this activation was associated with anxiety. We hypothesized that functional modulation of the right DLPFC by repetitive transcranial magnetic stimulation (rTMS) can reveal the actual role of right DLPFC in brain–gut interactions in humans.

Methods

Subjects were 11 healthy males aged 23.5 ± 1.4 (mean ± SE) years. Viscerosensory evoked potential (VEP) with sham (0 mA) or actual (30 mA) electrical stimulation (ES) of the rectum was taken after sham, low frequency rTMS at 0.1 Hz, and high frequency rTMS at 10 Hz to the right DLPFC. Rectal tone was measured with a rectal barostat. Visceral perception and emotion were analyzed using an ordinate scale, rectal barostat, and VEP.

Key results

Low frequency rTMS significantly reduced anxiety evoked by ES at 30 mA (p < 0.05). High frequency rTMS–30 mA ES significantly produced more phasic volume events than sham rTMS–30 mA ES (p < 0.05).

Conclusions and inferences

We successfully modulated the gastrointestinal function of healthy individuals through rTMS to the right DLPFC. Thus, rTMS to the DLPFC appears to modulate the affective, but not direct, component of visceral perception and motility of the rectum.

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Titel: Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans
verfasst von: Yuuichi Aizawa
Joe Morishita
Michiko Kano
Takayuki Mori
Shin-Ichi Izumi
Kenichiro Tsutsui
Toshio Iijima
Motoyori Kanazawa
Shin Fukudo
Publikationsdatum: 01.09.2011
Verlag: Springer Japan
Erschienen in: Journal of Gastroenterology / Ausgabe 9/2011
Print ISSN: 0944-1174
Elektronische ISSN: 1435-5922
DOI: https://doi.org/10.1007/s00535-011-0423-9

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Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans