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European Archives of Oto-Rhino-Laryngology

Erschienen in:

27.03.2019 | Otology

Effect of vascular endothelial growth factor and its receptors in adult otitis media with effusion

verfasst von: Mengxiao Ye, Xiping Li

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2019

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Abstract

Purpose

Some studies have demonstrated that vascular endothelial growth factor (VEGF) plays a critical role in the pathogenesis of otitis media with effusion (OME) in animal models. However, the levels of VEGF and its receptors in adult OME have not been clarified. Our study was designed to detect the levels of VEGF and its receptors in adult OME and explore their relationship with effusion types, duration and prognosis of OME.

Methods

61 patients with secretory otitis media were enrolled including 21 males and 40 females, with an average age of 54.7 ± 17.5 years. The middle-ear effusions were collected by tympanocentesis or myringotomy. The protein concentrations were determined by enzyme-linked immunosorbent assay and messenger RNA by real-time quantitative PCR.

Results

VEGF level was higher in AOME group, but not correlated with the recurrence of OME. VEGFR1 and VEGFR2 levels were lower in recurrent group compared with non-recurrent group. VEGFR2 level was higher in serous effusions than mucoid effusions. VEGF messenger RNA was positively correlated both with HIF-1α and MUC5B.

Conclusions

VEGF and its receptors function to induce the production of middle-ear effusions (MEEs) at acute stage of OME rather than chronic or recurrent stage, which is mainly mediated by HIF-1α pathway. The formation of mucoid effusions is associated with MUC5B and VEGFR2, but not with duration and recurrence of OME.

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Titel: Effect of vascular endothelial growth factor and its receptors in adult otitis media with effusion
verfasst von: Mengxiao Ye
Xiping Li
Publikationsdatum: 27.03.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2019
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05400-0

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Springer Medizin

Effect of vascular endothelial growth factor and its receptors in adult otitis media with effusion

Abstract

Purpose

Methods

Results

Conclusions

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Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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