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29.10.2021 | Original Article

Effects of apple cider vinegar on haemato-biochemical parameters of gestating rats and morphometric indices of their pups at delivery

verfasst von: Godwin Ikechukwu Ngwu, Blessing A. Opara, Maria Ifeyinwa Ngwu, Nnabuike C. Atuogba, Wilfred Ikechukwu Ugwuoke, Nelson I. Ossai, John I. Ihedioha, Solomon C. Njoku, Christopher Didigwu Nwani

Erschienen in: Comparative Clinical Pathology | Ausgabe 6/2021

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Abstract

Apple cider vinegar (ACV) is used globally as food supplement and widely acclaimed as therapeutic agent for various ill-health conditions. This study investigated the effect of consuming ACV during pregnancy on the haematological and biochemical profile of adult female albino rats in correlation with morphometric of the litters. Graded concentrations of ACV were administered to gestating albino rats to evaluate their effects on haematological and biochemical parameters of gestating rats and morphology of their pups at delivery. Ninety-six rats comprising 48 females (12 to 13 weeks old) and 48 males (15 weeks old) were used. The impregnated rats were randomly assigned to four groups (A, B, C and D) of 12 rats each. Each group was further sub-assigned into three replicates of four rats. Group A served as the untreated control while groups B, C and D were treated. Before and after 3-week period of treatment, blood samples were taken from the rats for haematological and serum biochemical evaluations following standard procedures. There were no significant variations (p > 0.05) between the groups in pup litter size, crown rump length and body mass index (BMI). There were also no significant variations (p > 0.05) between the groups in post-treatment values of packed cell volume, haemoglobin concentration, red blood cell count, absolute eosinophil counts and serum levels of calcium. Lower pup weight and higher litter size (at lower doses), lower lymphocyte and neutrophil counts, and lower serum activity of ALT, AST and ALP enzymes were recorded. ACV as used in this study has no adverse effects on haematological and biochemical profiles of gestating rats and their pups. It may therefore be safe to take ACV during pregnancy apart from other uninvestigated consequences.

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Titel: Effects of apple cider vinegar on haemato-biochemical parameters of gestating rats and morphometric indices of their pups at delivery
verfasst von: Godwin Ikechukwu Ngwu
Blessing A. Opara
Maria Ifeyinwa Ngwu
Nnabuike C. Atuogba
Wilfred Ikechukwu Ugwuoke
Nelson I. Ossai
John I. Ihedioha
Solomon C. Njoku
Christopher Didigwu Nwani
Publikationsdatum: 29.10.2021
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 6/2021
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-021-03294-1

Springer Medizin

Effects of apple cider vinegar on haemato-biochemical parameters of gestating rats and morphometric indices of their pups at delivery

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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