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Erschienen in:
01.12.2024 | Experimental Study
Effects of benidipine and amlodipine on viability of right deep circumflex iliac artery perforator flap: an experimental rat-model of reconstructive surgery
Erschienen in: European Journal of Plastic Surgery | Ausgabe 1/2024
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Background
There are studies showing the effects of calcium channel blockers on flap viability. The possible mechanism of action is vasodilation by blocking L-type calcium channels in the smooth muscle cells of the vascular wall. We aimed to compare the effects of benidipine and amlodipine on viability of the perforator flap rat-model.
Methods
Twenty-four Wistar-Albino rats were randomly divided into benidipine (3 mg/kg), amlodipine (1.5 mg/kg), and control group (2 ml saline). Right deep circumflex iliac artery (DCIA) perforator flap was removed and placed onto donor area. Tissue perfusion measurements were made using laser Doppler flowmetry from proximal and distal choke anastomosis areas on zeroth and tenth postoperative days. After sacrification, a full-thickness biopsy was taken from proximal and distal choke anastomosis areas.
Results
There was decrease in necrotic area and increase in flap viability but not significant between three groups (p > 0.05). Proximal and distal inflammation, vascularity, and collagenization did not differ significantly between groups (p > 0.05). The proximal and distal doppler values on day 10 increased significantly compared to those on day 0 in all groups (p < 0.05). The proximal Doppler values at day 0 and 10 and distal doppler values at day 0 did not differ significantly between groups (p > 0.05). However, the distal doppler values at day 10 was significantly higher in the benidipine group compared to those in the control and amlodipine groups (p = 0.044).
Conclusions
Present study showed that the benidipine reduced ischemic damage and necrosis and increased viability in DCIA perforator flap as much as amlodipine did, but not significantly. The benidipine was found to be at least as effective as amlodipine in terms of amelioration of blood flow and angiogenesis in perforator flaps. Underlying mechanisms dose-dependent relationship should be clearly demonstrated in further studies.
Level of evidence: Not ratable